Dibutyryl cyclic AMP inhibition of epidermal cell division

Beta2-adrenergic receptor agonist inhibits keratinocyte proliferation by mechanisms involving nitric oxide

“…NO donors have been used to inhibit proliferation, without producing significant cytotoxic effects, of a large variety of cell types, including those obtained from varying normal tissues and diverse tumours [ 16 ]. In the human epidermis, keratinocytes are able to present iNOS and ncNOS enzymatic activities resulting in the formation of NO [ 17 , 18 ]. Marletta et al [ 19 ] suggested that epidermal keratinocytes (HaCaT cells) with NO treatment were associated with a biphasic effect on cell proliferation, low dosages of NO donors mediated a proliferative signal to the cells, whereas high levels were cytostatic.…”

Beta2-adrenergic receptor agonist inhibits keratinocyte proliferation by mechanisms involving nitric oxide

“…NO donors have been used to inhibit proliferation, without producing significant cytotoxic effects, of a large variety of cell types, including those obtained from varying normal tissues and diverse tumours [ 16 ]. In the human epidermis, keratinocytes are able to present iNOS and ncNOS enzymatic activities resulting in the formation of NO [ 17 , 18 ]. Marletta et al [ 19 ] suggested that epidermal keratinocytes (HaCaT cells) with NO treatment were associated with a biphasic effect on cell proliferation, low dosages of NO donors mediated a proliferative signal to the cells, whereas high levels were cytostatic.…”

Beta2-adrenergic receptor agonist inhibits keratinocyte proliferation by mechanisms involving nitric oxide

“…NO donors have been used to inhibit proliferation, without producing significant cytotoxic effects, of a large variety of cell types, including those obtained from varying normal tissues and diverse tumours [ 16 ]. In the human epidermis, keratinocytes are able to present iNOS and ncNOS enzymatic activities resulting in the formation of NO [ 17 , 18 ]. Marletta et al [ 19 ] suggested that epidermal keratinocytes (HaCaT cells) with NO treatment were associated with a biphasic effect on cell proliferation, low dosages of NO donors mediated a proliferative signal to the cells, whereas high levels were cytostatic.…”

Beta2-adrenergic receptor agonist inhibits keratinocyte proliferation by mechanisms involving nitric oxide

“…NO donors have been used to inhibit proliferation, without producing significant cytotoxic effects, of a large variety of cell types, including those obtained from varying normal tissues and diverse tumours [ 16 ]. In the human epidermis, keratinocytes are able to present iNOS and ncNOS enzymatic activities resulting in the formation of NO [ 17 , 18 ]. Marletta et al [ 19 ] suggested that epidermal keratinocytes (HaCaT cells) with NO treatment were associated with a biphasic effect on cell proliferation, low dosages of NO donors mediated a proliferative signal to the cells, whereas high levels were cytostatic.…”