Diastolic wall strain is associated with incident heart failure in African Americans: Insights from the atherosclerosis risk in communities study

Kamimura, Daisuke; Suzuki, Takeki; Hall, Michael E.; Wang, Wanmei; Winniford, Michael D.; Shah, Amil M.; Rodríguez, Carlos J.; Butler, Kenneth R.; Mosley, Thomas H.

doi:10.1016/j.jjcc.2017.11.004

Cited by 7 publications

(7 citation statements)

References 41 publications

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“…Previous studies have reported that pulse wave velocity was increased in patients with PAD [21]. Notably, increased arterial stiffness has also been reported to be associated with LV myocardial stiffness and LV diastolic dysfunction [22][23][24]. Arterial stiffening increases LV [ ( F i g .…”

Section: Discussionmentioning

confidence: 99%

The impact of peripheral artery disease on left ventricular diastolic function

Yanaka

Akahori

Imanaka

et al. 2019

Journal of Cardiology

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Background: Peripheral artery disease (PAD) is often accompanied by heart failure with preserved ejection fraction (HFpEF). Left ventricular (LV) diastolic dysfunction is related to HFpEF. The aim of this study was to compare LV diastolic function between patients with or without PAD. Methods: One thousand one hundred twenty-one patients (male 56%, mean age 68 AE 13 years) with available preserved LV systolic function assessed by echocardiography (ejection fraction !50%) were enrolled from a single-center database between January 2013 and May 2015. PAD was defined as ankle brachial index <0.9 or previous history of lower extremity bypass and/or endovascular therapy. Diagnosis of LV diastolic dysfunction was based on the American Society of Echocardiography and European Association of Cardiovascular Imaging guidelines. The prevalence of LV diastolic dysfunction was compared between patients with PAD and those without PAD.Multivariate analysis was performed by logistic regression analyses to assess predictors of LV diastolic dysfunction. Results: Two hundred patients (18%) had PAD. Patients with PAD had higher E/e 0 (15.3 AE 7.4 vs 11.8 AE 5.5, p < 0.01), tricuspid regurgitation velocity (2.37 AE 0.33 vs 2.19 AE 0.28 m/s, p < 0.01), left atrial volume index (40.6 AE 20.2 vs 32.1 AE 13.6 mL/m 2 [ 1 _ T D $ D I F F ] , p < 0.01), and lower e 0 (5.68 AE 1.70 vs 6.38 AE 2.07 cm/s, p < 0.01) than patients without PAD. The prevalence of LV diastolic dysfunction was higher (31% vs 12%, p < 0.01) in patients with PAD compared to patients without PAD. Multivariate analysis showed that PAD was an independent predictor of LV diastolic dysfunction (adjusted odds ratio: 1.77, 95% confidence interval: 1.13-2.65, p = 0.01). Conclusion:The prevalence of LV diastolic dysfunction was higher in patients with PAD than patients without PAD.

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Section: Discussionmentioning

confidence: 99%

The impact of peripheral artery disease on left ventricular diastolic function

Yanaka

Akahori

Imanaka

et al. 2019

Journal of Cardiology

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“… [42] also suggested that antagonistic interaction is expected to occure if two risk factors share some common pathways in the pathogenesis of the disease outcome, and some of the specific pathways are saturated by either risk factor. It has previously been noted that elevated hs-TnT and low ABI share some common pathways, such as left ventricular dysfunction and hypertrophy [ 43 , 44 ], that were shown to subsequently lead to the development of cardiovascular events [ 45 , 46 ]. Additive interaction is relevant in translating findings to disease prevention [ 24 , 37 , 47 ]; however, it was found to be absent in the present study.…”

Section: Discussionmentioning

confidence: 99%

Joint effect of highly-sensitive cardiac troponin T and ankle-brachial index on incident cardiovascular events: The MESA and CHS

Tedla

Driver

Szklo

et al. 2023

American Journal of Preventive Cardiology

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“…However, the relationship between DWS and LV myocardial stiffness constant which is the gold standard to evaluate LV myocardial stiffness, was proved only in a basic experimental study and a correlation of only 0.4 does not "prove" that the LV myocardial stiffness could be accurately reflected by DWS. In addition, despite the animal study from Takeda et al proved that there was a lack of correlation between DWS and LV systolic function, wall thickness at the beginning of diastole, LV chamber size, indices derived from the transmitral flow velocity curves as well as preload alteration, recent clinical studies (43,46,47,50,53) found that DWS may not be a pure measure of diastolic function since it also correlates with systolic function. Therefore, DWS may be considered as an overall marker of cardiac performance, including systolic and diastolic mechanics.…”

Section: The Epicardial Movement Index (Emi) and Diastolic Wall Strai...mentioning

confidence: 99%

“…Similarly, Kamimura D et al (49) in 2017 found DWS to be significantly associated with HF symptoms in patients with AS with preserved ejection fraction (OR: 0.91, CI:0.86-0.96, P<0.005). Immediately thereafter, in 2018,Kamimura D et al (50) found both continuous and categorical DWS were independently associated with incident HF after adjustment for traditional risk factors and incident coronary artery disease (HR 1.21, 95%CI 1.04-1.41 for 0.1 decrease in continuous DWS, P= 0.014; HR 1.40, 95%CI 1.05-1.87 for the smallest DWS quintile vs other combined quintiles, P = 0.022), and in 2019 a study by Tsujimoto S, et al (51) showed low DWS ([?] 0.33) was a significant independent predictor of cardiovascular events after adjusting for cardiovascular comorbidities in a multivariable model (HR: 1.87, 95% CI 1.04-3.36, P=0.04).…”

Section: The Epicardial Movement Index (Emi) and Diastolic Wall Strai...mentioning

confidence: 99%

Evaluation of Left Ventricular Stiffness with Echocardiography

Wang

Zhang

et al. 2023

Preprint

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Half of patients with heart failure are presented with preserved ejection fraction (HFpEF). The pathophysiology of these patients is complex but increased left ventricular (LV) stiffness is proved to play a key role. However, the application of this parameter was limited since its measurements requires invasive catheterization. With advances in ultrasound technology, new advances have been achieved in the assessment of LV chamber or myocardial stiffness using noninvasive echocardiography. Therefore, this review was carried out to summarize the pathophysiological mechanisms, correlations with invasive LV stiffness constant, applications in different populations as well as the limitations of echocardiography-derived indices for assessment of both LV chamber and myocardial stiffness. LV chamber stiffness indices such as E/e’/LVEDV, E/SRe/LVEDV, and DPVQ were derived on the basis of the relationship between echocardiographic parameters of LVFP and LV size. However, all these methods are surrogate and lumped measurements, relying on E/e’ or E/SRe for evaluating LVFP. The limitations of E/e’ or E/SRe in assessment of LVFP may contribute to the moderate correlation between E/e’/LVEDV or E/SRe/LVEDV and LV stiffness constant. Even the best validated measurement (DPVQ) is considered unreliable in the individual patient. Compared to E/e’/LVEDV and E/SRe/LVEDV, I and F may display better performance in assessing LV chamber stiffness as evidenced by a higher correlation with LV stiffness constant. However, only one study has been conducted in the literature on the exploration and application of I /I and F /F , and its accuracy in assessing LV chamber stiffness remains to be confirmed. In terms of echocardiographic indices for LV myocardial stiffness evaluation, the parameters of EMI/DWS, iVP and SWI were proposed. Despite alteration of DWS and its predictive value of adverse outcomes in various populations have been widely validated, it was found that DWS may be better considered as an overall marker of cardiac function performance instead of pure myocardial stiffness. As for the iVP and SWI, the validities of these two indices in assessing LV myocardial stiffness have not been confirmed in invasive studies. More echocardiographic indices with higher sensitivities and specificities warrant to be further uncovered to evaluate LV stiffness.

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Diastolic wall strain is associated with incident heart failure in African Americans: Insights from the atherosclerosis risk in communities study

Abstract: DWS was independently associated with an increased risk of incident HF in a community-based cohort of African Americans. DWS could be used as a qualitative estimator of LV myocardial stiffness.

Cited by 7 publications

References 41 publications

The impact of peripheral artery disease on left ventricular diastolic function

The impact of peripheral artery disease on left ventricular diastolic function

Joint effect of highly-sensitive cardiac troponin T and ankle-brachial index on incident cardiovascular events: The MESA and CHS

Evaluation of Left Ventricular Stiffness with Echocardiography

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