2018 Has erratum 2019-5-22
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Abstract: A novel process, sequential coupled‐batch diastereomeric crystallization is presented for the resolution of racemic mixtures. This strategy utilized a preferential crystallization of diastereomeric salt followed by sequential coupled diastereomeric salt resolution of racemic ibuprofen with the resolving agent (S)‐lysine utilizing a novel small scale pneumatic liquid exchange design to couple two batch crystallizers. Results were compared to conventional sequential resolution via seeded isothermal batch crystal… Show more

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Cited by 10 publications
(13 citation statements)
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References 48 publications
(52 reference statements)
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“…Enantiomers are stereoisomers that are mirror images of each other. In the synthetic production of materials with specific optical properties, it is hard to prevent the counterenantiomer (which is not always beneficial) from spontaneously accompanying the targeted product . Thus, the separation of chiral products is of significance, especially in the fields of pharmaceuticals, agrochemistry, and biotechnology.…”
Section: Obtaining a Specific Pharmaceutical Crystalline Product From...mentioning
confidence: 99%
See 1 more Smart Citation
“…Enantiomers are stereoisomers that are mirror images of each other. In the synthetic production of materials with specific optical properties, it is hard to prevent the counterenantiomer (which is not always beneficial) from spontaneously accompanying the targeted product . Thus, the separation of chiral products is of significance, especially in the fields of pharmaceuticals, agrochemistry, and biotechnology.…”
Section: Obtaining a Specific Pharmaceutical Crystalline Product From...mentioning
confidence: 99%
“…In the synthetic production of materials with specific optical properties, it is hard to prevent the counterenantiomer (which is not always beneficial) from spontaneously accompanying the targeted product. 88 Thus, the separation of chiral products is of significance, especially in the fields of pharmaceuticals, agrochemistry, and biotechnology. At present, the main methods for resolving racemic conglomerates are chiral chromatography and preferential crystallization.…”
Section: Polymorphism In Continuousmentioning
confidence: 99%
“… 12 , 13 A major focus of this research is the development of design and optimization strategies that deliver robust, tunable, and scalable API manufacturing processes, delivering specific API characteristics. 14 18 …”
Section: Introductionmentioning
confidence: 99%
“… 21 Continuous stirred tank reactors (CSTRs), mixed suspension mixed product removal (MSMPR) crystallizers, and tubular and oscillatory flow crystallizers have been demonstrated to be able to monitor, characterize, model, and control all important crystal product attributes for pharmaceuticals such as crystal size distribution (CSD), 2 , 13 , 14 , 22 25 morphology, 13 , 14 , 22 chemical purity, 11 , 12 , 26 yield, 11 , 12 , 26 , 27 chirality, 28 or polymorphic purity. 28 32 …”
Section: Introductionmentioning
confidence: 99%
“…Crystallization is a key operation in pharmaceutical production, and a number of continuous crystallization platforms have been demonstrated to be viable, with sufficiently robust operation, while being capable of commercial levels of supply . Continuous stirred tank reactors (CSTRs), mixed suspension mixed product removal (MSMPR) crystallizers, and tubular and oscillatory flow crystallizers have been demonstrated to be able to monitor, characterize, model, and control all important crystal product attributes for pharmaceuticals such as crystal size distribution (CSD), ,,, morphology, ,, chemical purity, ,, yield, ,,, chirality, or polymorphic purity. …”
Section: Introductionmentioning
confidence: 99%