Diarrhea or colorectal cancer: Can bacterial toxins serve as a treatment for colon cancer?

Impact of Microbial Infections on the Human Epigenome and Carcinogenesis

“…Lastly, research has demonstrated that some bacterial toxins may have cancer protective effects [65], notably by pathogens commonly found in areas of low-incidence CRC, but where diarrheal diseases are prevalent [66]. The molecular mechanisms behind such enterotoxigenic Escherichia coli (ETEC) infections are developing, and may suggest a role for preventive measures or new therapeutic targets in the future [67].…”

Bacterial genotoxins, gene methylation, and RNA interference: Pointing to colorectal cancer as an infectious disease?

“…Lastly, research has demonstrated that some bacterial toxins may have cancer protective effects [46], notably by pathogens commonly found in areas of low-incidence CRC, but where diarrheal diseases are prevalent [47]. The molecular mechanisms behind such enterotoxigenic Escherichia coli (ETEC) infections are developing, and may suggest a role for preventive measures or new therapeutic targets in the future [48].…”

Role of Yersinia enterocolitica heat-stable enterotoxin (Y-STa) on differential regulation of nuclear and cytosolic calcium signaling in rat intestinal epithelial cells

“…It is also known that calcium signals in the nucleus have specific biological effects like the regulation of cell growth and gene transcription (Carrion et al 1999;Hardingham et al 1997). It has been reported earlier that E. coli STa, a major causative agent of secretory diarrhea, also plays a significant role in cell cycle regulation in colon carcinoma cells (Carrithers 2000;Pitari et al 2003). Moreover, Pitari et al (2003) has provided convincing evidence that E. coli STa inhibits deoxyribonucleic acid synthesis in colon carcinoma cells by a calciummediated signaling mechanism.…”