Diamonds are for men, too

Sommer, Andrei P.

doi:10.21037/atm.2017.08.33

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…Photobiomodulation (PBM) is a therapeutic method that utilizes light with specific wavelengths, usually in the range of 400–1100 nm, to stimulate the photobiochemical reactions and trigger non‐heating physical photonic effects at multiple living levels 1,2 . These photon‐tissue interactions have been demonstrated to have beneficial effects on promoting cell proliferation, suppressing neuroinflammation, reducing pain, and promoting the healing of wounds, deeper tissues and nerves 3–6 .…”

Section: Introductionmentioning

confidence: 99%

Recent advances in photobiomodulation therapy for brain diseases

Dong,

Ren,

Zhang

et al. 2024

Interdisciplinary Medicine

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Light therapy techniques, such as photobiomodulation therapy (PBMT), photodynamic therapy (PDT), and laser photoablation, have gained widespread attention and become indispensable physiotherapy methods in clinical practice. PBMT involves the application of low‐level laser/LED to modulate the function of nerve cells, relieve neuroinflammation, promote neurogenesis and vascular growth. Recent studies have shown that PBMT holds promise as a complementary or alternative treatment of Alzheimer's disease (AD), traumatic brain injury (TBI), major depressive disorder (MDD), etc. However, the therapeutic effect of PBMT is influenced by various factors, such as the patients' condition, brain structure and function, illumination parameters, etc. Therefore, the optimized parameters, personalized therapeutic schedules, and precise evaluation of the therapeutic effect are crucial to the treatment success. In this review, we identified the recent experimental and clinical successes, existing obstacles, and future opportunities for PBMT in the treatment of the brain diseases. As a non‐invasive, side‐effect‐free, and highly accessible technique, PBMT brings a glimmer of light for the treatment of neuropsychiatric disorders and the neuro‐rejuvenation of human brains.

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Section: Introductionmentioning

confidence: 99%

Recent advances in photobiomodulation therapy for brain diseases

Dong,

Ren,

Zhang

et al. 2024

Interdisciplinary Medicine

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Aging Is a Sticky Business

Sommer¹

2018

Photomedicine and Laser Surgery

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Revisiting the Photon/Cell Interaction Mechanism in Low-Level Light Therapy

Sommer¹

2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Objective: Several reports claim that the enzyme cytochrome c oxidase (CCO) is the primary absorber for redto-near-infrared (R-NIR) light in cells and causal for mitochondrial adenosine triphosphate (ATP) upregulation, and that pulsed R-NIR light has frequent therapeutic effects, which are superior to those of the continuous wave (CW) mode used in low-level light therapy (LLLT). Background data: Convincing evidence that the absorption of R-NIR photons by CCO is involved in mitochondrial ATP upregulations as well as a coherent explanation for the superiority of the pulsed irradiation mode is presently lacking in the literature. Methods: A comprehensive literature search and rigorous analysis of the data published on the idea that CCO is the primary absorber for R-NIR light, and of the claim that the effectivity of the pulsed irradiation mode can be derived from the absorption of R-NIR photons by CCO, reveal a number of severe inconsistencies. Results: A systematical analysis covering both the theory that CCO is the primary acceptor for R-NIR light and of its use to interpret differences between the biological effect of pulsed light and CW casts doubt on the general validity of the CCO-based hypothesis. Instead, we are offered a simple and conflict-free model accounting for both ATP upregulation and superiority of the pulsed mode in LLLT, which is in agreement with the results of recent laboratory experiments. Conclusions: CCO is not the primary acceptor for R-NIR light.

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Diamonds are for men, too

Cited by 4 publications

References 21 publications

Recent advances in photobiomodulation therapy for brain diseases

Recent advances in photobiomodulation therapy for brain diseases

Aging Is a Sticky Business

Revisiting the Photon/Cell Interaction Mechanism in Low-Level Light Therapy

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