Diamondoid Hydrocarbons--Delving into Nature's Bounty

Marchand, Alan P.

doi:10.1126/science.1079630

Cited by 81 publications

(73 citation statements)

References 4 publications

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“…ORs are generally expressed in cell membranes of olfactory receptor neurons (antennae) (Getz and Akers, 1994;Murphy et al, 2003;Vosshall et al, 1999). However, additional functions of OR proteins have been suggested (Feingold et al, 1999;Itakura et al, 2006;Xu et al, 2000) because of their localization to different ectopic tissues (non-olfactory tissues), such as germ cells and testis tissue in mammals (Fukuda et al, 2004;Marchand, 2003;Spehr et al, 2003;Vanderhaeghen et al, 1997;Ziegler et al, 2002). Recent experiments also show that one OR in honey bee antennal neurons can respond to a component of QMP (Wanner et al, 2007).…”

Section: Qmp Jh-ecdysteroid Hormone Axes and The Worker Ovarymentioning

confidence: 99%

Regulation of behaviorally associated gene networks in worker honey bee ovaries

Wang

Kocher

Linksvayer

et al. 2012

Journal of Experimental Biology

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Fat body expression of hormone receptor-like in 46 (HR46) and phosphoinositide-dependent kinase-1 (PDK1) correlates with ovary size as well as worker division of labor (Wang et al., 2009). HR46 is a possible nuclear hormone receptor for ecdysteroid hormones Accepted 28 September 2011 SUMMARY Several lines of evidence support genetic links between ovary size and division of labor in worker honey bees. However, it is largely unknown how ovaries influence behavior. To address this question, we first performed transcriptional profiling on worker ovaries from two genotypes that differ in social behavior and ovary size. Then, we contrasted the differentially expressed ovarian genes with six sets of available brain transcriptomes. Finally, we probed behavior-related candidate gene networks in wild-type ovaries of different sizes. We found differential expression in 2151 ovarian transcripts in these artificially selected honey bee strains, corresponding to approximately 20.3% of the predicted gene set of honey bees. Differences in gene expression overlapped significantly with changes in the brain transcriptomes. Differentially expressed genes were associated with neural signal transmission (tyramine receptor, TYR) and ecdysteroid signaling; two independently tested nuclear hormone receptors (HR46 and ftz-f1) were also significantly correlated with ovary size in wild-type bees. We suggest that the correspondence between ovary and brain transcriptomes identified here indicates systemic regulatory networks among hormones (juvenile hormone and ecdysteroids), pheromones (queen mandibular pheromone), reproductive organs and nervous tissues in worker honey bees. Furthermore, robust correlations between ovary size and neural-and endocrine response genes are consistent with the hypothesized roles of the ovaries in honey bee behavioral regulation. Supplementary material available online at

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Section: Qmp Jh-ecdysteroid Hormone Axes and The Worker Ovarymentioning

confidence: 99%

Regulation of behaviorally associated gene networks in worker honey bee ovaries

Wang

Kocher

Linksvayer

et al. 2012

Journal of Experimental Biology

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“…Diamondoids are a unique form of carbon nanostructure best described as hydrogen-terminated diamond molecules 1 . The 28 surface dangling carbon bonds are all saturated by hydrogen atoms.…”

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confidence: 99%

Spatially resolved electronic and vibronic properties of single diamondoid molecules

Wang

Kioupakis

et al. 2007

Nature Mater

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“…The history of the adamantane polycyclic cage in chemistry did not take off until Schleyer 65 reported a synthetic route to derive these "diamondoids" (adamantane's structure mimicks the lattice structure of diamond). 66 Although amantadine was first used clinically to treat the influenza virus, serendipitous observation by a clinician led to the observation that Parkinson's disease patients who were treated with amantadine for the flu had improved symptomatology. 67 Another important polycyclic cage amine, is memantine, an amino-adamantane used to clinically treat Alzheimer's disease.…”

Section: Adamantane Aminesmentioning

confidence: 99%

Polycyclic Compounds: Ideal Drug Scaffolds for the Design of Multiple Mechanism Drugs?

Schyf

Geldenhuys

2009

Neurotherapeutics

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Summary:Recently there has been a resurging interest in developing multi-functional drugs to treat diseases with complex pathological mechanisms. Such drug molecules simultaneously target multiple etiologies that have been found to be important modulators in specific diseases. This approach has significant promise and may be more effective than using one compound specific for one drug target or, by a polypharmaceutical approach, using a cocktail of two or more drugs. Polycyclic ring structures are useful as starting scaffolds in medicinal chemistry programs to develop multi-functional drugs, and may also be useful moieties added to existing structures to improve the pharmacokinetic properties of drugs currently used in the clinic or under development. This review attempts to provide a synopsis of current published research to exemplify the use of polycyclic compounds as starting molecules to develop multi-functional drugs.

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Diamondoid Hydrocarbons--Delving into Nature's Bounty

Cited by 81 publications

References 4 publications

Regulation of behaviorally associated gene networks in worker honey bee ovaries

Regulation of behaviorally associated gene networks in worker honey bee ovaries

Spatially resolved electronic and vibronic properties of single diamondoid molecules

Polycyclic Compounds: Ideal Drug Scaffolds for the Design of Multiple Mechanism Drugs?

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