Kuan Yoow Chan, Marisa Alonso-Nuñez, Agnes Grallert, Kayoko Tanaka, Yvonne Connolly, Duncan L. Smith, Iain M. Hagan
Abstract:Events at the fission yeast equivalent of the centrosome, the spindle pole body, determine the timing of mitotic commitment and mitotic exit. Previous work has established that events on Cut12 drive commitment, whereas events on a distinct scaffold, Sid4 drive exit. Chan et al. now show how signaling on Sid4 influences commitment to explain the rationale for using the centrosome as a signaling center; centrosomal signaling supports integration of outputs from distinct inputs.
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