Diagnostik und Therapie choroidaler Melanome

Lipski, Andreas; Lakotka, N; Riechardt, Aline I.; Willerding, G; Heufelder, Jens; Türkmen, Seval; Keilholz, Ulrich; Moser, Lutz; Joussen, Antonia M.

doi:10.1055/s-0033-1350833

Cited by 7 publications

(6 citation statements)

References 59 publications

(76 reference statements)

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“…Das uveale Melanom ist der häufigste maligne intraokulare Tumor im Erwachsenenalter [1]. Das Ziel der multimodalen Therapie ist es, eine lokale Tumorkontrolle zu gewährleisten und das Auge mit bestmöglichem Visus zu erhalten.…”

Section: Hintergrundunclassified

Zehn Jahre multimodale Therapie uvealer Melanome an der Universitätsaugenklinik Innsbruck

Rauchegger

Blatsios

Haas

et al. 2019

Spektrum Augenheilkd.

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Section: Hintergrundunclassified

Zehn Jahre multimodale Therapie uvealer Melanome an der Universitätsaugenklinik Innsbruck

Rauchegger

Blatsios

Haas

et al. 2019

Spektrum Augenheilkd.

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“…Das maligne Melanom der Aderhaut ist der häufigste primäre intraokulare maligne Tumor des Erwachsenenalters [1][2][3]. Die Inzidenz liegt bei etwa 5:100.000 pro Jahr [1][2][3]. Die Inzidenz steigt mit zunehmendem Lebensalter [1][2][3].…”

unclassified

“…Die Inzidenz liegt bei etwa 5:100.000 pro Jahr [1][2][3]. Die Inzidenz steigt mit zunehmendem Lebensalter [1][2][3]. Das Melanom der Aderhaut führt oft erst spät zu Symptomen.…”

unclassified

“…Das Melanom der Aderhaut führt oft erst spät zu Symptomen. Die Prognose quoad vitam des Aderhaumelanoms ist schlecht, etwa 50 % der Patienten entwickeln Fernmetastasen [1][2][3]. Im Gegensatz zum kutanen Melanom zeigt das uveale Melanom einen starken Tropismus zur Lebermetastasierung und metastasiert (bis auf Tumoren mit extraokularer Ausdehnung) ausschließlich hämatogen [4].…”

unclassified

“…Denn unabhängig von der Therapie des Primärtumors am Auge (Enukleation, Endoresektion, Blockexzision, Brachytherapie, Protonenbestrahlung etc.) ist die Prognose quoad vitam schlecht und bisher durch adjuvante Therapieansätze nicht zu beeinflussen [1][2][3]. Besonders Aderhautmelanome mit Monosomie 3 sind mit einer dramatisch schlechten Prognose vergesellschaftet [7], da es meist bald zum Auftreten von Lebermetastasen und in Folge innerhalb von Monaten zum Tode des Patienten kommt.…”

unclassified

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Immuntherapie beim Aderhautmelanom: Vakzination gegen Krebs

Schuler‐Thurner

Bartz‐Schmidt²,

Bornfeld

et al. 2015

Ophthalmologe

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Uveal melanomas are the most common malignant tumors of the eye. With modern molecular biological diagnostic methods, such as chromosome 3 typing and gene expression analysis, these tumors can be categorized into highly aggressive (monosomy 3, class II) and less aggressive forms. This molecular biological stratification is primarily important for determining the risk of these tumors as no therapy is currently available that is able to prevent or delay metastases. A randomized study of patients with a poor prognosis (monosomy 3) is currently being carried out in order to determine whether a cancer vaccine prepared from autologous (patient's own) dendritic cells and uveal melanoma RNA can prevent or delay progression and further metastases of this extremely aggressive form of cancer. Inclusion in the uveal melanoma study, which hopes to provide a potential therapeutic option for patients, is only possible if patients are referred to an institution that is able to manufacture and provide this vaccination before the patient is operated on or treated with radiation. Untreated tumor material is necessary for producing the vaccine on an individualized patient basis.

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Immunotherapy of Uveal Melanoma: Vaccination Against Cancer

Kummer

Schuler‐Thurner

2016

RNA Vaccines

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Uveal melanoma is the most frequently occurring primary intraocular tumor in adults, with an incidence of about 5 out of 100,000 per year, the incidence rising with increasing age (Lipski, Klin Monbl Augenheilkd 230:1005-1019, 2013; Metz et al., Klin Monbl Augenheilkd 230:686-691, 2013; Singh and Topham, Ophthalmology 110:956-961, 2003). Often diagnosed late due to a lack of early symptoms, this kind of melanoma is associated with a poor prognosis. Approximately 50 % of the patients develop distant metastases (Lipski, Klin Monbl Augenheilkd 230:1005-1019, 2013; Metz et al., Klin Monbl Augenheilkd 230:686-691, 2013; Singh and Topham, Ophthalmology 110:956-961, 2003). In sharp contrast to cutaneous melanoma, uveal melanoma shows a strong liver tropism and spreads exclusively via the hematogenous route (except for tumors with extraocular expansion) (Heindl et al., Arch Ophthalmol 128:1001-1008, 2010). The most likely reason for this observation is the lack of lymphatic vessels in the choroid and alymphatic barrier of the sclera (Schlereth et al., Exp Eye Res 125:203-209, 2014; Schroedl et al., Invest Ophthalmol Vis Sci 49:5222-5229, 2008). Due to its location in the immune-privileged eye, the uveal melanoma is widely protected from the immune system. Therefore, the goal of the approach presented here, of a "personalized vaccination therapy" is to help the immune system recognize and fight the tumor.

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Diagnostik und Therapie choroidaler Melanome

Abstract: However, metastatic disease still remains a fatal condition which currently may only be influenced by early detection and treatment of uveal melanomas.

Cited by 7 publications

References 59 publications

Zehn Jahre multimodale Therapie uvealer Melanome an der Universitätsaugenklinik Innsbruck

Zehn Jahre multimodale Therapie uvealer Melanome an der Universitätsaugenklinik Innsbruck

Immuntherapie beim Aderhautmelanom: Vakzination gegen Krebs

Immunotherapy of Uveal Melanoma: Vaccination Against Cancer

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