Diagnostics and treatment of orbital myositis

Pidro, Aida; Dizdarević, Admira; Jovanović, Nina; Cerim, Alma; Sačak, Emina; Miokovic, Ajla Pidro

doi:10.22336/rjo.2022.34

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…Typical clinical signs include orbital discomfort, moderate to severe pain in the orbit or periorbital area, painful double vision increasing with eye movements, exophthalmos, swollen eyelids, conjunctival congestion, or chemosis [20,21]. The muscle most affected by inflammation is the medial rectus muscle, followed by the superior rectus muscle, lateral rectus muscle, and inferior rectus muscle, in contrast to TO in which inflammatory lesions usually affect the inferior rectus muscle [22].…”

Section: Reviewmentioning

confidence: 99%

Differential diagnosis of thyroid orbitopathy — diseases mimicking the presentation or activity of thyroid orbitopathy

Nowak,

Marek

et al. 2024

Endokrynol Pol

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with no previous or concomitant symptoms of thyroid disorders, lack of symptoms of eyelid retraction, divergent strabismus, diplopia as the only symptom of the disease, and a history of increasing diplopia at the end of the day.The inflammatory activity and severity of TO should be diagnosed based on personal experience and according to standard diagnostic criteria. Assessment of TO inflammatory activity can be performed using the clinical activity score (CAS). Magnetic resonance imaging (MRI) is not necessary to diagnose typical cases of TO but may be necessary to assess the inflammatory activity of TO, especially in those with a so-called "posterior" course. Orbital MRI is indicated in patients with unilateral or highly asymmetric exophthalmos, suspected optic nerve neuropathy, and TO with euthyroidism, while computed tomography (CT) of the orbit is par-

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Section: Reviewmentioning

confidence: 99%

Differential diagnosis of thyroid orbitopathy — diseases mimicking the presentation or activity of thyroid orbitopathy

Nowak,

Marek

et al. 2024

Endokrynol Pol

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“…The main types of orbital inflammation are thyroid eye disease and nonspecific orbital inflammation 1 , which includes a group of noninfectious lesions lacking characteristic pathological changes. These lesions, known as idiopathic orbital inflammation, are immune inflammations that occur in the tissues of the orbit 2 . Nonspecific orbital inflammation primarily affects both eyes and is more common in adults, with no gender or ethnic differences observed 3 .…”

Section: Introductionmentioning

confidence: 99%

Weak acid-initiated slow release of Dexamethasone from hydrogel to treat orbital inflammation

Li¹,

Zhang²,

Zhao³

et al. 2023

Theranostics

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Rationale: Orbital inflammation is a prevalent and prolonged ocular disease that poses a significant challenge to clinicians. Glucocorticoid Dexamethasone sodium phosphate (Dex) has demonstrated efficacy in the clinical treatment of nonspecific orbital inflammation. However, frequent administration is required due to the short half-life of Dex, which may lead to drug waste and adverse side effects. Methods: In this study, we co-assembled Dex with a weak acid responsive hydrogelator Py-Phe-Phe-Lys-Lys-OH (K) to obtain a novel supramolecular hydrogel Dex/K that could release Dex in a slow manner to treat orbital inflammation. The therapeutic effect of Gel Dex/K on orbital inflammation was verified by in vitro and in vivo experiments. Results: In vitro experiments indicated that co-assembly of Dex with K significantly increased mechanic strength of the hydrogel, enabling a continuous release of 40% of total Dex within 7 days. In vivo experiments further demonstrated that sustained release of Dex from Gel Dex/K could effectively alleviate the infiltration of inflammatory cells and the release of inflammatory factors in the orbit of mice, improving symptoms such as increased intraocular pressure and proptosis. Additionally, Gel Dex/K mitigated the degree of tissue fibrosis and fatty infiltration by reducing the development of local inflammation in the orbit. Conclusions: Our research results indicate that Gel Dex/K could more efficiently achieve responsive drug release in orbit, providing an innovative method for treating orbital inflammation.

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Diagnostik bei Diplopie

Lischka

2024

Springer Reference Medizin

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Diagnostics and treatment of orbital myositis

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 7 publications

Differential diagnosis of thyroid orbitopathy — diseases mimicking the presentation or activity of thyroid orbitopathy

Differential diagnosis of thyroid orbitopathy — diseases mimicking the presentation or activity of thyroid orbitopathy

Weak acid-initiated slow release of Dexamethasone from hydrogel to treat orbital inflammation

Diagnostik bei Diplopie

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