Diagnostic Value of Serum N-Terminal Pro B-Type Natriuretic Peptide (Nt-Probnp) for Left Ventricular Dysfunction in Hypertensive Cases.

Abstract

Objective: Left ventricular hypertrophy (LVH) is an independent risk factor for all cardiovascular complication of hypertension (HTN), in this group, early detection is very important for better management. Therefore, the aim of our study is to evaluate cardiac markers in HTN with LVH. Methods:The study comprised 95 patients with the evidence of HTN. These cases were further divided into two groups, i.e., HTN without LVH and HTN with LVH groups. We assessed blood pressure, electrocardiography, and echocardiography. All the cardiac markers were assessed. Results:In the cases of LVH with HTN group, the serum cardiac parameter such as N-terminal pro-brain natriuretic peptide (NT-proBNP) was significantly raised. However, the serum myoglobin and creatine kinase-MB (CK-MB) did not showed any significant rise when compared with control. In the cases of LVH without HTN, all these three parameters not have shown any significant raise when compared with control. Conclusion:Apart from imaging techniques, the assessment of serum NT-proBNP act as better marker for identifying LVH than the traditional markers such as CK-MB and myoglobin.