1998
DOI: 10.1055/s-2007-1010251
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Abstract: In this study it was demonstrated that ECC and the use of aprotinin did not have any influence on the secretion of PCT. A systemic bacterial infection caused a significant increase of PCT, whereas PCT values remained normal in case of a SIRS. So it seems to be possible to distinguish between a primary SIRS and a bacterial sepsis by means of PCT.

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Cited by 26 publications
(17 citation statements)
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“…Most patients with PCT levels higher than 2.0 ng/ml and neopterin levels higher than 20 nmol/l developed organ dysfunction. Earlier studies have demonstrated that CPB itself does not have a significant effect on the PCT secretion; however, infection following cardiac surgery is always accompanied by high PCT values [22,30]. Moreover, in the study by Hensel et al [31] all patients with postoperative acute lung injury and without any sign of infection had a PCT level above 5 ng/ml.…”
Section: Discussionmentioning
confidence: 92%
See 1 more Smart Citation
“…Most patients with PCT levels higher than 2.0 ng/ml and neopterin levels higher than 20 nmol/l developed organ dysfunction. Earlier studies have demonstrated that CPB itself does not have a significant effect on the PCT secretion; however, infection following cardiac surgery is always accompanied by high PCT values [22,30]. Moreover, in the study by Hensel et al [31] all patients with postoperative acute lung injury and without any sign of infection had a PCT level above 5 ng/ml.…”
Section: Discussionmentioning
confidence: 92%
“…Surgery involving CPB may also lead to the development of systemic inflammatory response. The release of inflammatory mediators such as interleukin-6, interleukin-8, tumor necrosis factor, PCT, neopterin, and NO during and after the operation has previously been reported [2,21,22]. Determination of nitric oxide radical itself is difficult because of its very short half-life.…”
Section: Discussionmentioning
confidence: 99%
“…Although we described the relationship between preoperative PCT levels and postoperative respiratory function, it was impossible to define it because of the small patient number in this study. However, it has been reported that the postoperative PCT reflected on postoperative complications and mortality [3, 4, 6]. Additionally, we have paid attention to the relationship between postoperative respiratory function and SIRS following CPB or cardiovascular surgery, especially under perioperative conditions, in AAD patients.…”
Section: Discussionmentioning
confidence: 99%
“…Several authors have demonstrated complement activation, cytokine release, endotoxemia, and other features of systemic inflammatory response syndrome (SIRS) immediately following cardiopulmonary bypass (CPB) [3, 4]. In acute aortic dissection (AAD), SIRS may occur even preoperatively.…”
Section: Introductionmentioning
confidence: 99%
“…Boeken et al 35 found no significant elevation of blood PCT in patients with uncomplicated CABO, whereas in patients who developed SIRS the levels rose to values not exceeding 0·9ltg/L. In a group developing severe sepsis, blood PCT rose to 18·6±6·3ltg/L.…”
Section: Procalcitonin As a Marker Of Infection Following Surgerymentioning
confidence: 94%