Diagnostic value of platelet parameters versus interleukin-6 in children with urinary tract infection

Zayed, Khaled M.; Abdelhakeem, Ahmed Mohsen; Gafar, Heba S.; Eldahshan, Tarek Abd El Kareim

doi:10.1016/j.epag.2016.04.002

Cited by 7 publications

(10 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of present study indicated that the number of platelets was significantly higher in UTIs, but with no significant difference between the patient and the control groups was observed in terms of MPV, which is similar to the results by Togan (28). It has been observed that there is a difference in platelet indices, including PLT, MPV, and PDW regarding the different clinical conditions (1,3,14,21). However, in contrast to our results, previous reports have shown that MPV is a useful index in the diagnosis of infectious and inflammatory diseases such as endocarditis, Crohn's disease, and ulcerative colitis (29)(30)(31).…”

Section: Discussionsupporting

confidence: 88%

“…Some studies have reported that platelets play an important role in the pathogenesis of various inflammatory diseases, including inflammatory bowel disease, colitis, ankylosing spondylitis, and rheumatoid arthritis (22)(23)(24)(25)(26)(27). Platelets were also referred to as an indicator of urinary tract infection (3). The results of present study indicated that the number of platelets was significantly higher in UTIs, but with no significant difference between the patient and the control groups was observed in terms of MPV, which is similar to the results by Togan (28).…”

Section: Discussionsupporting

confidence: 88%

“…Therefore, alternative methods of UTI diagnosis which can be faster and more effective are needed. Chang in platelet parameters has been reported as an index for rapidly presumptive diagnosis of urinary tract infection without waiting for urine culture results (3). It can be used as an inflammatory index of immune response during infections (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

“…When activated, they participate in host defense system through the phagocytosis and the production of free cytotoxic radicals and oxidative molecules (9). Platelets can also enhance the inflammatory process by increasing the leukocyte recruitment and apoptosis prevention of monocytes and neutrophils, as well as, increasing inflammatory mediators such as chemokine and cytokines (3,10). It has been reported that thrombocytosis occur during the urinary tract infection, which is actually the bone marrow response to the platelet usage during the infection, as they are involved in the host defense system (1).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Platelet Indices as Useful Indicators of Urinary Tract Infection

Akya

Rostami-Far

Lorestani

et al. 2019

IJPHO

View full text Add to dashboard Cite

Background: The changes of platelet parameters can be a useful index for rapid diagnosis of urinary tract infection (UTI), since platelet changes are routinely determined through complete blood count (CBC) test. The correlation between platelet indices, included number (PLTs), mean platelet volume (MPV) and platelet distribution width (PDW), which are the indicators of production and function of platelets, with UTI was evaluated in this study. Materials and Methods: In this descriptive-analytical study, 97 patients with UTI (patient group) and 117 healthy people (control group). The average age for the patient and the control group was 10.84±6.68 and 11.34±7.1 years old, respectively. This study was done during 2016-2018 in Imam Reza Hospital, Kermanshah, west of Iran. The PLT, MPV, PDW, and other inflammatory indices, including white blood cell, neutrophils, lymphocytes, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were evaluated. The diagnosis of bacteria was done using routine microbiological and biochemical methods. The platelet indices were statistically compared between the patients and the control groups (T test and Chi square test). Results: The most common isolated gram negative and gram positive bacteria were E. coli, Citrobacter, and Staphylococcus aureus, respectively. In the patient group, PLT number was significantly higher than that in the control group (p=0.0007), while difference of other indices such as MPV, PDW, neutrophils, lymphocytes, CRP, and ESR were not statistically significant between the two groups. In case of UTI with gram positive bacteria, PLT number (p=0.05) was lower but MPV (p=0.02) and PDW (p=0.045) was higher compared to the UTI with gram negative bacteria. Conclusion: The results of this study showed that the platelet number could be a useful diagnostic index for urinary tract infection. However, more studies need to be done with higher number of patients to evaluate the more details of platelet changes during UTIs.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Platelet Indices as Useful Indicators of Urinary Tract Infection

Akya

Rostami-Far

Lorestani

et al. 2019

IJPHO

View full text Add to dashboard Cite

show abstract

“…PDW which indicates changes in platelet size is correlated with the activity of the platelet. 13,30 Changes in this index have been reported as a marker to evaluate various inflammatory and infectious diseases. 13,31 In our study, although the mean values for PLT, MPV, and PDW were lower in the brucellosis group, there were no statistically significant changes (P>0.05).…”

Section: Discussionmentioning

confidence: 99%