Diagnostic value of microRNA panel in endometrial cancer: A systematic review

Abstract

Purpose: We conducted a systematic review to evaluate the overall diagnostic accuracy of miRNAs in detecting endometrial cancer. Materials and Methods: A systematic search of Medline, Embase, Cinahl and the Cochrane Controlled Register of Trials was performed to identify studies reporting on the diagnostic value of miRNA in EC patients. Included were diagnostic studies looking at miRNA expression in women diagnosed with endometrial cancer. Two reviewers independently selected studies and assessed quality of studies using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) score system. Data extraction was completed and the vote-counting strategy was used to rank miRNAs. Results: 26 studies were included with a total number of 1,400 EC patients reporting on 106 differentially expressed miRNAs. The most frequently found upregulated miRNA was miR-205 followed by miR-200c,-223,-182,-183 and-200a. In addition, miR-135b, miR-429, miR-141 and miR-200b were also frequently upregulated. There was less consensus on down-regulated miRNAs. Conclusions: miRNAs yield a promising diagnostic biomarker potential in endometrial cancer, especially miR-205, the miR-200 family and miR-135b,-182,-183 and-223. However, no sufficient high quality data are available to draw hard conclusions. More research is needed to validate the diagnostic potential of these miRNAs in larger studies. In addition, the potential of urine as a non-invasive biofluid should be investigated in more detail.

MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review

“…This systematic review identified 105 original articles and two literature reviews reporting the expression pattern of miRNAs [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ,…”

“…Methylation Modified Reference miR-381 X [125,169] miR-382 X [146] miR-409 X [126] miR-410 X [121,125,169] miR-411 X [127,169] miR-421 X [125] miR-423 X [126,130] miR-424 X [125,126,169] miR-424* X [125] miR-424-3p X [117] miR-425 X [126,169] miR-429 X [114,117,121,125,129,169,177] miR-431 X [125,126] miR-432 X X [125,129] miR-449 X [29,129] miR-450a X [169] miR-451 X [126] miR-455-3p X [169] miR-455-5p X [169] miR-483-5p X [169] miR-487b X [127] miR-494 X [169] miR-495 X [132] miR-496 X [126] miR-497 X [169] miR-499 X [118] miR-501-5p X [169] miR-503 X [120,125,126,<...>…”

Insulin Resistance and Endometrial Cancer: Emerging Role for microRNA

“…As for endometrial neoplasia, a 4-miRNA signature (miR-4758, miR-876, miR-142, miR-190b) has been established as an independent prognostic factor for overall survival in EC patients (area under the curve (AUC) of receiver operating characteristic (ROC) curve was 0.7 at 5-year overall survival) [150]. By contrast, based on their systematic review, Donkers et al proposed miR-205, the whole miR-200 family, miR-135b, miR-182, miR-183, and miR-223 as promising diagnostic biomarkers in EC [151]. Such studies were performed in the hope that the expression pattern of miRNA would become an early diagnostic and prognostic biomarker, whilst particular miRNAs could be identified as novel therapeutic targets.…”

Usefulness of microRNA detection in the diagnostics of endometrial cancer

“…8 A recent systematic review showed a promising diagnostic potential of a miRNA panel for EC. 9 The miR-NAs miR-205, the miR-200 family (comprising miR-200a, -200b, -200c, -141, and -429), miR-135b, -182, -183, and -223 were found to be upregulated most consistently. 9 MicroRNAs have been shown to be stable in formalin-fixed paraffin-embedded (FFPE) tissue samples, which are routinely archived in most hospitals and are, therefore, widely used for the discovery of clinically useful biomarkers.…”

“…9 The miR-NAs miR-205, the miR-200 family (comprising miR-200a, -200b, -200c, -141, and -429), miR-135b, -182, -183, and -223 were found to be upregulated most consistently. 9 MicroRNAs have been shown to be stable in formalin-fixed paraffin-embedded (FFPE) tissue samples, which are routinely archived in most hospitals and are, therefore, widely used for the discovery of clinically useful biomarkers. 10 Therefore, in this study we aim to test and validate the potential of a distinct miRNA panel in FFPE tissue as a first step in optimizing it as a diagnostic tool for the detection of EC.…”