Diagnostic Value of 99m Tc- Labeled-Ubiquicidin 29-41 (99m Tc-UBI) Scan in the Diagnosis of Vertebral Osteomyelitis

Ghodsirad, Mohammad Ali; Aryana, Kamran; Samini, F; Sadeghi, Ramin

doi:10.2174/1573405613666170504152003

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“…In recent years, various investigations have been conducted to evaluate the efficacy of using 99m Tc-UBI scintigraphy as a direct method in the detection of musculoskeletal infections such as assessment of vertebral osteomyelitis (33 %-100 % sensitivity and 95 %-87.5 % specificity) [18,19], delineation between osteomyelitis and bone tumors (73.6 % sensitivity and 100 % specificity) [23], mediastinitis (83 % sensitivity and 85 % specificity) [24] and endocarditis [25].…”

Section: Original Articlementioning

confidence: 99%

“…UBI (29-41) is a safe synthetic agent for humans; and so far no complications have been reported after its use [10,11,[13][14][15][16][17]. According to the literature, the 99m Tc-UBI scan has a key role in diagnosing osteomyelitis in the diabetic foot, infectious spondylitis, and musculoskeletal and periprosthetic infection detection [9,10,[13][14][15][16][17][18][19]. UBI (29-41) is a cationic antimicrobial micro peptide consisting of thirteen amino acids [16,20].…”

Section: Introductionmentioning

confidence: 99%

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Application of 99mTc-UBI 29–41 scintigraphy in knee periprosthetic infection diagnosis

et al. 2019

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Aim In recent years, the use of total knee arthroplasty (TKA) is considered a safe and cost-effective orthopedic procedure for alleviating the chronic pain and treatment of progressive osteoarthritis. This procedure may have some complications including periprosthetic infection as the most serious and aseptic loosening as the most common one. Differentiating between these entities is important because each has a different therapeutic approach. This study was conducted to investigate the ability of 99mTC-UBI scan to distinguish septic from aseptic loosening in a painful knee prosthesis. Methods 34 patients with painful knee prostheses were included. The 99mTC-UBI scan was done immediately after IV administration of 99mTC-UBI in early dynamic and 30-minute static images. Time-activity curve (TAC) was drawn for all patients and target to non-target ratio (T/NT) was calculated on 30-minute images. The final diagnosis was confirmed by surgical findings, microbiologic culture results or active clinical follow up. Results Using TAC analysis, 24 99mTC-UBI scans were considered negative and 10 positive for an infectious process. Sensitivity, specificity, negative and positive predictive values were 56 %, 80 %, 83 %, and 50 %, respectively. T/NT ratio analysis on 30-minute static images demonstrated 9 positive and 25 negative patterns, with a cut off value of 1.83 for the T/NT ratio. The sensitivity, specificity, negative and positive predictive values, and accuracy of this test modality were all 100 %. Conclusions Our findings show 99mTc-UBI scan is an excellent clinical diagnostic test for differentiating septic from aseptic loosening of the knee prostheses with perfect sensitivity and specificity. Highly accurate results were obtained only 30 minutes after injection.

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Section: Original Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of 99mTc-UBI 29–41 scintigraphy in knee periprosthetic infection diagnosis

et al. 2019

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Diagnostic Value of 99m Tc- Labeled-Ubiquicidin 29-41 (99m Tc-UBI) Scan in the Diagnosis of Vertebral Osteomyelitis

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Application of 99mTc-UBI 29–41 scintigraphy in knee periprosthetic infection diagnosis

Application of 99mTc-UBI 29–41 scintigraphy in knee periprosthetic infection diagnosis

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Diagnostic Value of 99m Tc- Labeled-Ubiquicidin 29-41 (99m Tc-UBI) Scan in the Diagnosis of Vertebral Osteomyelitis

Cited by 1 publication

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﻿Application of 99mTc-UBI 29–41 scintigraphy in knee periprosthetic infection diagnosis

﻿Application of 99mTc-UBI 29–41 scintigraphy in knee periprosthetic infection diagnosis

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Application of 99mTc-UBI 29–41 scintigraphy in knee periprosthetic infection diagnosis

Application of 99mTc-UBI 29–41 scintigraphy in knee periprosthetic infection diagnosis