Diagnostic Utility of Total IgE in Foods, Inhalant, and Multiple Allergies in Saudi Arabia

Al-Mughales, Jamil A.

doi:10.1155/2016/1058632

Cited by 15 publications

(12 citation statements)

References 25 publications

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“…Moreover, the estimated cost of asthma diagnosis and treatment is also on the rise [15]. Earlier research conducted in KSA and neighboring countries has drawn parallels to the reported clinical and immunological phenotypes [16,17]. Some of these studies reported a potential link between elevated blood eosinophilia and severe or uncontrolled asthma.…”

Section: Introductionmentioning

confidence: 99%

Immunological Factors Associated with Adult Asthma in the Aseer Region, Southwestern Saudi Arabia

Al-Ghamdi

Koshak

Omer

et al. 2019

IJERPH

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Background: The prevalence of asthma is on the rise in Saudi Arabia. Data regarding the immunological profile of asthma in adults in the Aseer region, in southwestern Saudi Arabia, have not been well studied. Objectives: Our aim was to study the immunological factors associated with sensitization to asthma among adults in the Aseer region. Methods: A cross-sectional study with a nested case control design in a 1:1 ratio was conducted on a sample of adults attending primary health care centers in the Aseer region. The study used a validated Arabic version of the International study of asthma and allergies in childhood (ISAAC) questionnaire. The presence of wheezing in the past 12 months was used as a proxy for bronchial asthma. Matched age and sex controls were selected. Both groups were tested for complete blood count (CBC), total and differential white blood cell (WBC) count including eosinophils, total immunoglobulin E (IgE) measurement, allergen-specific immunoglobulin E (IgE), and cytokine levels. Results: The present study included 110 cases and 157 age- and sex-matched controls. Rye wheat was found to be a significant outdoor sensitizing agent ((odds ratio) OR = 5.23, 95% CI: 1.06–25.69). Indoors, house dust mites Dermatophagoides petronyssinus (OR = 2.04, 95% CI: 1.04–3.99) and Dermatophagoides farinae (OR = 2.50, 95% CI: 1.09–5.75) were significant. Higher total IgE (OR = 1.84, 95% CI: 1.10–3.06) and eosinophil levels (OR = 2.85, 95% CI: 1.14–7.15) were significantly associated with adult bronchial asthma in Aseer. On the other hand, the role of cytokines was not significant. Conclusions: In the present study, certain environmental agents were found to be important with regards to sensitization to bronchial asthma in adults. Knowledge about these sensitization agents should be disseminated to health providers and treating physicians in order to enhance preventive environmental control measures and asthma management. Asthma-treating physicians in the region should be alerted to the use of targeted biological therapies in selected asthmatics with difficult-to-control courses.

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Section: Introductionmentioning

confidence: 99%

Immunological Factors Associated with Adult Asthma in the Aseer Region, Southwestern Saudi Arabia

Al-Ghamdi

Koshak

Omer

et al. 2019

IJERPH

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“…Therefore, there has been considerable interest in the validity of total IgE level as diagnostic tool for allergy. However, the diagnostic value of total IgE levels seems to be limited, although many patients with allergic disorders have elevated levels of total IgE (121719272829303132). A Taiwanese study calculated that the cut-off value of total IgE for discriminating between an atopy and non-atopy group was 77.7 kU/L, with sensitivity and specificity of 82.3% and 87.1%, respectively (17).…”

Section: Discussionmentioning

confidence: 99%

“…A Taiwanese study calculated that the cut-off value of total IgE for discriminating between an atopy and non-atopy group was 77.7 kU/L, with sensitivity and specificity of 82.3% and 87.1%, respectively (17). A Saudi Arabian study also reported a total IgE specificity of 83.4% for the allergic group, but sensitivity was only 61.3% when the cut-off level was 195 kU/L (32). …”

Section: Discussionmentioning

confidence: 99%

Reference Values and Utility of Serum Total Immunoglobulin E for Predicting Atopy and Allergic Diseases in Korean Schoolchildren

et al. 2017

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The present study aimed to investigate the distribution of total serum immunoglobulin E (IgE) levels in Korean schoolchildren and to evaluate its utility in the prediction of atopy and allergic diseases. A nationwide, cross-sectional survey was conducted in first grade students from randomly selected elementary and middle schools. Total IgE levels were measured by ImmunoCAP. Skin prick tests were performed for 18 common inhalant allergens to determine the presence of atopy. Children aged 12–13 years and parents of children aged 6–7 years were asked to complete questionnaire assessing allergic diseases. The cut-off levels of total IgE were determined by analyzing receiver operating characteristic curves. The median total IgE level was 86.7 kU/L (range: 1.5–4,523.1) in 3,753 children aged 6–7 years and 94.7 kU/L (range: 1.5–3,000.0) in 3,930 children aged 12–13 years. Total IgE concentrations were higher in children with atopy or allergic diseases than in those without (all P < 0.001). At the cut-off value of 127.7 kU/L, sensitivity, specificity, and positive and negative predictive values (PPV and NPV) were 67.1%, 75.4%, 65.4%, and 76.7%, respectively, in elementary schoolchildren. At the cut-off value of 63.0 kU/L, sensitivity, specificity, PPV, and NPV were 81.9%, 66.6%, 75.0%, and 75.1%, respectively, in middle schoolchildren. PPV and NPV were ≥ 70% when cut-offs of 258.8 kU/L and 38.4 kU/L were used for the diagnosis of atopy in 6–7 year-olds and 12–13 year-olds, respectively. This nationwide population-based study provided the first normal reference ranges of total IgE in Korean schoolchildren.

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“…Immunoglobulin E (IgE) is of central importance in the regulation of immune responses against parasitic infestations and most importantly, it is also recognized as a main mediator for immediate-type allergies or type I hypersensitivity reactions, such as allergic asthma, rhinitis, atopic diseases, anaphylaxis, etc. (Al-Mughales, 2016). It is a potent mast cell activator able to trigger mast cell degranulation and downstream responses with a minute amount (Actor, 2014).…”

Section: Inhibition Of Allergen-specific Igementioning

confidence: 99%

Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action

2019

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The prevalence of allergic diseases such as asthma, allergic rhinitis, food allergy and atopic dermatitis has increased dramatically in recent decades. Conventional therapies for allergy can induce undesirable effects and hence patients tend to seek alternative therapies like natural compounds. Considering the fact above, there is an urgency to discover potential medicinal plants as future candidates in the development of novel anti-allergic therapeutic agents. The Lamiaceae family, or mint family, is a diverse plant family which encompasses more than 7,000 species and with a cosmopolitan distribution. A number of species from this family has been widely employed as ethnomedicine against allergic inflammatory skin diseases and allergic asthma in traditional practices. Phytochemical analysis of the Lamiaceae family has reported the presence of flavonoids, flavones, flavanones, flavonoid glycosides, monoterpenes, diterpenes, triterpenoids, essential oil and fatty acids. Numerous investigations have highlighted the anti-allergic activities of Lamiaceae species with their active principles and crude extracts. Henceforth, this review has the ultimate aim of compiling the up-to-date (2018) findings of published scientific information about the anti-allergic activities of Lamiaceae species. In addition, the botanical features, medicinal uses, chemical constituents and toxicological studies of Lamiaceae species were also documented. The method employed for data collection in this review was mainly the exploration of the PubMed, Ovid and Scopus databases. Additional research studies were obtained from the reference lists of retrieved articles. This comprehensive summarization serves as a useful resource for a better understanding of Lamiaceae species. The anti-allergic mechanisms related to Lamiaceae species are also reviewed extensively which aids in future exploration of the anti-allergic potential of Lamiaceae species.

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Diagnostic Utility of Total IgE in Foods, Inhalant, and Multiple Allergies in Saudi Arabia

Cited by 15 publications

References 25 publications

Immunological Factors Associated with Adult Asthma in the Aseer Region, Southwestern Saudi Arabia

Immunological Factors Associated with Adult Asthma in the Aseer Region, Southwestern Saudi Arabia

Reference Values and Utility of Serum Total Immunoglobulin E for Predicting Atopy and Allergic Diseases in Korean Schoolchildren

Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action

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