Diagnostic Utility and Prognostic Value of Basic Laboratory Parameters in COVID-19

Ulusoy, Tülay Ünver; Demirköse, Mesut; Bilek, Heval Can

doi:10.36519/kd.2021.3666

Cited by 7 publications

(8 citation statements)

References 24 publications

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“…23,24 Although the AUC values obtained for the NLR were found to be statistically significant, as in our study, in studies conducted to distinguish between patients with COVID-19 and patients with COVID-19-like symptoms, sufficient specificity and sensitivity values could not be obtained in terms of diagnostic predictiveness. 5,25 Monocytes play an essential role in maintaining the inflammatory response. A previous study found that monocytosis had the highest AUC value and specificity among hemogram parameters.…”

Section: Discussionmentioning

confidence: 99%

Hemogram Parameters Cannot Distinguish Pediatric COVID-19 from Other Respiratory Infections

Çelik,

Kasap,

Çakan

et al. 2024

JPA

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To fight against the pandemic, which has become the most significant public health problem of modern times, the isolation of patients and early detection of the coronavirus-2019 (COVID-19) disease are crucial. This study aimed to show the diagnostic predictor of hemogram parameters and the rates obtained from these parameters in differentiating COVID-19 from other respiratory tract diseases. Data of patients aged between 1 month and 18 years who were admitted to the 3rd and 2nd level pediatric emergency with the pre-diagnosis of “COVID-19-like disease” between 12 January 2022 and July 12, 2022, which is one month after the Omicron (Nu) variant was accepted as an established variant in Türkiye, were retrospectively reviewed. A total of 724 children with pre-diagnosis of COVID-19-like disease whose complete blood count and Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) polymerase chain reaction (PCR) test from oropharynx/nasopharyngeal swab samples were included in the study. Two hundred children were positive for SARS-CoV-2 PCR (27.6%). Total leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, platelets, platelet distribution width, platelet crit counts, and neutrophil/lymphocyte ratio were lower, and hemoglobin values were higher in the COVID-19 group than in the other group. These differences were statistically significant (p<0.05). When these parameters were evaluated by receiver operating characteristic analysis, the area under the curve values of the other parameters, except the eosinophil count, were statistically significant. However, when the obtained possibility ratios were examined, significant cut-off values could not be obtained regarding diagnostic predictiveness. It was found that using complete blood count parameters in the diagnostic process is not helpful in differentiating SARS-CoV-2 from other respiratory tract diseases. It is essential to conduct studies with larger sample sizes to understand whether complete blood count parameters can predict the diagnosis of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Hemogram Parameters Cannot Distinguish Pediatric COVID-19 from Other Respiratory Infections

Çelik,

Kasap,

Çakan

et al. 2024

JPA

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“…An increase in comorbid diseases, weakening of the immune system, and decreased physiological functions are risk factors for COVID-19 in elderly patients [ 18 ]. In a study conducted by Teker et al [ 19 ] with 654 patients, they found that the prognosis of the disease worsened, and mortality rates increased with age.…”

Section: Discussionmentioning

confidence: 99%

“…The detection of high CRP levels before the occurrence of tomography findings is effective in the early diagnosis of the disease [ 12 ]. In many studies, increased CRP levels have been associated with poor prognosis and mortality [ 6 , 18 , 23 ]. Contrary to many studies, no statistically significant association was found between mortality and CRP in our study.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Laboratory Findings and Mortality in COVID-19 Patients Requiring Intensive Care

Bahçeci¹,

Mercantepe²,

Duran³

et al. 2023

Cureus

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Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shows a wide clinical manifestation from asymptomatic infection to life-threatening respiratory failure. This study aimed to determine the relationship between the survival and demographic data, comorbidity status, and laboratory parameters of coronavirus disease 2019 (COVID-19) patients requiring intensive care.Material and methods: We retrospectively analyzed 236 patients requiring intensive care whose diagnosis was confirmed by the SARS-CoV-2 reverse transcription-polymerase chain reaction (RT-PCR) test. The patients were divided into two groups in terms of survival. Demographic data; procalcitonin and C-reactive protein (CRP) levels; leukocyte, lymphocyte, and neutrophil counts in hemogram and neutrophil-tolymphocyte ratio (NLR) levels; and lower respiratory and blood cultures were examined, and the relationships between these parameters and survival were evaluated with hypothesis testing.Results: In the study, 156 (66.1%) males and 80 (33.9%) females, a total of 236 patients, were included. Sixty-seven (28.3%) surviving patients were determined as Group 1, and 169 (71.7%) deceased patients were determined as Group 2. A statistically significant difference was found between the groups in terms of mean age (p<0.001) and gender distribution (p=0.011). In laboratory parameters, a significant difference was observed between the groups in lymphocyte count (p=0.001), NLR (p<0.001), and procalcitonin levels (p<0.001). Although leukocyte (p=0.075), neutrophil (p=0.031), and CRP (p=0.112) levels were higher in Group 2, there was no statistical difference. Mortality was found to be higher in patients with comorbidity (p=0.012) or co-infection (p=0.002).Conclusion: High levels of neutrophil count, NLR, and procalcitonin; low lymphocyte count; the presence of comorbidity; and secondary bacterial infection were found to be associated with mortality in COVID-19 patients in the intensive care unit.

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“…Teker et al [ 23 ] found that the course of COVID-19 worsened with increasing age and number of deaths. Unver-Ulusoy et al [ 24 ] found that 68.8% of patients hospitalized in the intensive care unit were aged 65 years and older. According to information reported by the US Centers for Disease Control and Prevention, the mortality rate observed in ≥65 patients is higher [ 25 ] and it is thought that weakened immune functions in elderly patients predispose to infection.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, the effect of gender on COVID-19 and mortality risk was investigated by Doerre and Doblhammer [ 29 ] In the study, it was determined that the mortality rate in females were 2 times higher than in males. Ünver-Ulusoy et al [ 24 ] found that men had a higher risk of death. Peckham et al [ 30 ] found that male patients were almost 3 times more likely to be admitted to the intensive care unit and had a higher mortality rate than female patients.…”

Section: Discussionmentioning

confidence: 99%

Reporting of biochemical blood values in COVID-19 patients: A retrospective study

Eriten,

Eriten

2023

Medicine

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Background: This study aimed to investigate the impact of biochemical blood parameters on the progression of coronavirus disease (COVID-19). This retrospective study analyzed the clinical characteristics and biochemical test parameters of 352 COVID-19 patients treated at Malatya Training and Research Hospital in Turkey between March 3, 2021, and February 28, 2022. Methods: The methodological approach of our study included specific analyses and examinations to assess the effect of biochemical blood values on disease progression in COVID-19 patients. To achieve this aim, blood samples were collected from patients and various biochemical tests were performed. The data obtained were evaluated using statistical analyses to examine the relationship between these specific biochemical blood values and the severity of COVID-19. Results: High glucose, urea, alkaline phosphatase and lactate dehydrogenase levels and low albumin and potassium levels were associated with a more severe disease course. The results showed a significant link between certain biochemical blood values and the severity of COVID-19. These findings suggest that these markers may serve as valuable clinical indicators for predicting the disease progression and severity. Conclusion: This study demonstrates the importance of monitoring and analyzing biochemical blood values as essential tools for assessing the severity and progression of COVID-19. The identified markers provide valuable information regarding the prognosis of the disease and may help healthcare professionals make informed decisions regarding patient care.

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Diagnostic Utility and Prognostic Value of Basic Laboratory Parameters in COVID-19

Cited by 7 publications

References 24 publications

Hemogram Parameters Cannot Distinguish Pediatric COVID-19 from Other Respiratory Infections

Hemogram Parameters Cannot Distinguish Pediatric COVID-19 from Other Respiratory Infections

The Relationship Between Laboratory Findings and Mortality in COVID-19 Patients Requiring Intensive Care

Reporting of biochemical blood values in COVID-19 patients: A retrospective study

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