Diagnostic potential of microRNAs Mi 517 and Mi 526 as biomarkers in the detection of hypertension and preeclampsia in the first trimester

Kondracka, Adrianna; Kondracki, Bartosz; Jaszczuk, Ilona; Staniczek, Jakub; Stupak, Aleksandra; Filip, Agata; Kwaśniewska, Anna

doi:10.5603/gp.a2023.0036

Cited by 1 publication

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Circulating levels of miR-942 were lower at midpregnancy (12-20 weeks' gestation) in women with preeclampsia than in the control A study by Luque et al [153] indicated that the assessment of maternal serum microR-NAs at the end of the first trimester of pregnancy does not appear to have any predictive value for early preeclampsia. Other studies, however, have strongly supported the need for more detailed exploration of microRNAs in the maternal circulation since they represent potential biomarkers for pregnancy-related complications [146,152,158,159]. There is a need to consider that increased placental dysfunction may stimulate the gradual release of placental mediators, including miRNAs, into the maternal circulation, leading to further diffuse maternal vascular damage and increased differential profiles of circulating miRNAs only at later stages of gestation.…”

Section: Mirnas and Prediction Of Preeclampsiamentioning

confidence: 99%

Circulating miRNAs and Preeclampsia: From Implantation to Epigenetics

Giannubilo,

Cecati,

Marzioni

et al. 2024

IJMS

View full text Add to dashboard Cite

In this review, we comprehensively present the literature on circulating microRNAs (miRNAs) associated with preeclampsia, a pregnancy-specific disease considered the primary reason for maternal and fetal mortality and morbidity. miRNAs are single-stranded non-coding RNAs, 20–24 nt long, which control mRNA expression. Changes in miRNA expression can induce a variation in the relative mRNA level and influence cellular homeostasis, and the strong presence of miRNAs in all body fluids has made them useful biomarkers of several diseases. Preeclampsia is a multifactorial disease, but the etiopathogenesis remains unclear. The functions of trophoblasts, including differentiation, proliferation, migration, invasion and apoptosis, are essential for a successful pregnancy. During the early stages of placental development, trophoblasts are strictly regulated by several molecular pathways; however, an imbalance in these molecular pathways can lead to severe placental lesions and pregnancy complications. We then discuss the role of miRNAs in trophoblast invasion and in the pathogenesis, diagnosis and prediction of preeclampsia. We also discuss the potential role of miRNAs from an epigenetic perspective with possible future therapeutic implications.

show abstract