Diagnostic performances of intravoxel incoherent motion and conventional diffusion-weighted imaging in the differential diagnosis of benign and malignant portal vein thrombus

Aumann, Emel Kaya; Server, Sadık; Sökmen, Bedriye Koyuncu; Öz, Ayşegül; Namal, Esat; Gürcan, Nagihan İnan; Balci, N. Cem; Tokat, Yaman

doi:10.1007/s00261-018-1467-6

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…Our findings support the observations of previous studies in which DW signal intensity and ADC measurements were found to reliably distinguish between benign and malignant PVT in patients with HCC; the vascularity of the thrombus, as well as the presence of malignant cells, may have affected both DW signal intensity and ADC values of the thrombi (2,(22)(23)(24). Furthermore, our results showed that CEUS findings correlated well with DWI-MRI findings; CEUS findings may be more accurate, especially for the diagnosis of malignant PVT with infiltrative HCC.…”

Section: Discussionsupporting

confidence: 91%

Diagnostic Role of Contrast-enhanced Ultrasound in the Discrimination of Malignant Portal Vein Thrombosis in Patients With Hepatocellular Carcinoma

et al. 2020

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Background/Aim: To investigate the accuracy of contrast-enhanced ultrasound (CEUS) in differentiating benign and malignant portal vein thrombosis (PVT) complicating hepatocellular carcinoma (HCC), compared to diffusionweighted magnetic resonance imaging (DWI). Patients and Methods: Forty-nine patients with HCC who had PVT were enrolled. The quantitative and qualitative parameters of CEUS were analysed. We examined the diagnostic performance of CEUS compared with DWI. The relationships between CEUS parameters and biomarkers were also assessed. Results: All qualitative CEUS parameters (e.g., arterial-phase enhancement, washout in the venous phase, vessel occlusion, and expansion) were significantly more common in malignant thrombosis than in benign thrombosis (p<0.05). Among the quantitative CEUS parameters, increased area under the timeintensity curve, prolonged time for full width at half maximum, and prolonged rise time were observed in malignant thrombosis, compared to benign thrombosis (p<0.05). CEUS and DWI performed similarly in discriminating between malignant and benign thrombi (p>0.05). Several CEUS parameters exhibited significant correlations with the tumour marker and stage (p<0.05). Conclusion: CEUS was useful for characterisation of PVT and showed a consistent high diagnostic accuracy, compared to DWI.

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Section: Discussionsupporting

confidence: 91%

Diagnostic Role of Contrast-enhanced Ultrasound in the Discrimination of Malignant Portal Vein Thrombosis in Patients With Hepatocellular Carcinoma

et al. 2020

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“…Use of multimodal MRI, especially the ADC parameter, can help to distinguish between benign and malignant PVTs. Aumann et al (23) reported that the ADC value can effectively differentiate benign and malignant PVTs, with sensitivity and specificity values of 80.0% and 72.7%, Patients with PVT from January 2011 to April 2016 (n=564) Excluded:…”

Section: Discussionmentioning

confidence: 99%

Value of susceptibility-weighted imaging in differentiating benign from malignant portal vein thrombosis

Huang¹,

Xiao²,

Guo³

et al. 2023

Quant Imaging Med Surg

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Background: Many diseases are accompanied by portal vein thrombosis (PVT), and its nature is closely related to its prognosis and treatment. It is important to evaluate magnetic resonance imaging (MRI) parameters, including susceptibility-weighted imaging (SWI) and qualitative diffusion-weighted imaging (DWI), in the differentiation between benign and malignant PVT.Methods: In this retrospective study, we collected clinical imaging data from 140 patients with PVTs characterized as benign or malignant based on enhanced MRI between January 2011 and April 2016 and retrospectively analyzed PVTs using SWI and DWI. There were 37 benign and 103 malignant PVTs. Image review was performed by 2 radiologists blinded to clinical information. The signal intensity (SI) of PVTs was recorded on SWI. The apparent diffusion coefficient (ADC) and the ratio of signal intensity (SIR) on SWI (SIR SWI ) and ADC (SIR ADC ) between the PVTs and the spinal cord were calculated. Finally, we generated receiver operating characteristic (ROC) curves to evaluate the efficacy of SIR SWI and SIR ADC for distinguishing benign and malignant PVTs.Results: On SWI and DWI, 100.0% (36/36) and 80.5% (29/36) of benign PVTs were hypointense, respectively. For malignant PVTs on SWI and DWI, 99.0% (103/104) and 89.4% (93/104) were hyperintense, respectively. The SIR SWI values of benign and malignant PVTs were 0.58±0.13 and 0.88±0.06, respectively, representing a significant difference (P<0.001). The SIR ADC values of benign and malignant PVTs were 0.72±0.32 and 0.62±0.17, respectively, representing a significant difference (P=0.034). The area under the ROC curve (AUROC) for SIR SWI [0.990; 95% confidence interval (CI): 0.971-1.000] was significantly higher than that for SIR ADC (0.619; 95% CI: 0.500-0.737; P<0.001). The SIR SWI had a sensitivity of 100.0% and a specificity of 97.3% with a cutoff value of 0.749, while the SIR ADC had a sensitivity of 45.9% and specificity of 83.3% with a cutoff value of 0.791. Conclusions:The diagnostic performance of SWI is superior to that of DWI in the differentiation of benign and malignant PVTs.

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“…The use of an increased number of b-values leads to extended acquisition time and motion artefacts. Respiratory triggered sequences can reduce the respiratory motion artefacts [21]. Although we used respiratory navigation, we excluded 3 patients due to motion-related artefacts.…”

Section: Discussionmentioning

confidence: 99%

Intravoxel Incoherent Motion of Colon Cancer Liver Metastases for the Assessment of Response to Antiangiogenic Treatment: Results from a Pilot Study

et al. 2020

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Highlights of the Study • Intravoxel incoherent motion (IVIM) is a diffusion imaging method which is used clinically for the evaluation of tissue perfusion without the use of contrast media. • The f (perfusion fraction) value of IVIM may quantitatively reflect the response of antiangiogenic therapy. • IVIM could be added in routine protocols for magnetic resonance imaging to assess response of tumors to antiangiogenic agents.

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Diagnostic performances of intravoxel incoherent motion and conventional diffusion-weighted imaging in the differential diagnosis of benign and malignant portal vein thrombus

Abstract: ADC values might be more superior tool than IVIM parameters in differentiation between malignant and benign PVT.

Cited by 4 publications

References 34 publications

Diagnostic Role of Contrast-enhanced Ultrasound in the Discrimination of Malignant Portal Vein Thrombosis in Patients With Hepatocellular Carcinoma

Diagnostic Role of Contrast-enhanced Ultrasound in the Discrimination of Malignant Portal Vein Thrombosis in Patients With Hepatocellular Carcinoma

Value of susceptibility-weighted imaging in differentiating benign from malignant portal vein thrombosis

Intravoxel Incoherent Motion of Colon Cancer Liver Metastases for the Assessment of Response to Antiangiogenic Treatment: Results from a Pilot Study

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