Diagnostic performance of hematological discrimination indices to discriminate between βeta thalassemia trait and iron deficiency anemia and using cluster analysis: Introducing two new indices tested in Iranian population

Abstract

Although the discrimination between β-thalassemia trait (βTT) and Iron deficiency anemia (IDA) is important clinically, but it is challenging and normally difficult; so if a patient with IDA is diagnosed as βTT, then it is deprived of iron therapy. This study purpose was to evaluate the 26 different discriminating indices diagnostic function in patients with microcytic anemia by using accuracy measures, and also recommending two distinct new discriminating indices as well. In this study, 907 patients were enrolled with the ages over 18-year-old with either βTT or IDA. Twenty-six discrimination indices diagnostic performance presented in earlier studies, and two new indices were introduced in this study (CRUISE index and index26) in order to evaluate the differential between βTT and IDA by using accuracy measures. 537 (59%) patients with βTT (299 (56%) women, and 238 (44%) men), and also 370 (41%) patients with IDA (293 (79%) women, and 77 (21%) men) were participated in this study for evaluating the 28 discrimination indices diagnostic performance. Two new introduced indices (CRUISE index and index26) have better performance than some discrimination indices. Indices with the amount of AUC higher than 0.8 had very appropriate diagnostic accuracy in discrimination between βTT and IDA, and also CRUISE index has good diagnostic accuracy, too. The present study was also the first cluster analysis application in order to identify the homogeneous subgroups of different indices with similar diagnostic function. In addition, new indices that offered in this study have presented a relatively closed diagnostic performance by using cluster analysis for the different indices described in earlier studies. Thus, we suggest the using of cluster analysis in order to determine differential indices with similar diagnostic performances.

November

“…From the research conducted, it was found that there were significant differences between hemoglobin levels, MCV values, RDW values, Mentzer Index and ferritin levels in iron deficiency anemia patients with beta minor thalassemia patients. This is in line with previous studies that conducted research on the use of a new index for hematological parameters to differentiate cases of iron deficiency anemia from cases of beta minor thalassemia 17 . levels between patients with iron deficiency anemia and beta minor thalassemia patients with p values <0.001.…”

Difference of Het Re Level In Thalassemia β Minor And Iron Deficiency Anemia

“…The results found significant differences between, hemoglobin levels, MCV values, MCH values, ferritin levels between patients with iron deficiency anemia and minor beta thalasemia patients with a p<0.001 value. However, there was no significant difference between the RDW value of patients with iron deficiency anemia and minor beta thalasemia patients with a value of p=0.94 17 .…”

“…The data analysis was conducted on 42 patients with a male gender of 4 (9.5%) with an average age of 17 Median hemoglobin (Hb) levels of iron deficiency anemia and thalasemia were found to be 9.60% and 9.80% (p 0.0037). Median MCV value and mentzer index of minor beta thalassemia patients were lower than iron deficiency anemia (61.59; 12.30) while the median RDW value of thalasemia patients was higher (16.60).…”

Identification of Thalassemia Carrier in Anemic Pregnant Women at Puskesmas Kertapati Palembang: Comparison of Five Erythrocyte Indices

“…However, anemia can occur every trimester in pregnancy (Paendong, Suparman, and Tendean, 2016;Amini, Pamungkas, and Harahap, 2018). (Jahangiri, Rahim and Malehi, 2019). Low sensitivity means that the index is not capable enough to classify pregnant women as a Thalassemia carrier (Parikh et al, 2008).…”