Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans

Shieh, Eric; Lee, Ramon; Que, Christian; Srinivasan, Vivek J.; Guo, Rong; DeLuna, Regina; Pandit, Sumir; Simavlı, Hüseyin; Seevaratnam, Rajini; Tsikata, Edem; Boer, Johannes F. de; Chen, Teresa C.

doi:10.1016/j.ajo.2016.06.028

Cited by 27 publications

(50 citation statements)

References 49 publications

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“…The currently estimated mean PIMD‐2 π agrees with previous measures of MDB (Shieh et al. ) and global BMO‐MRW (Chauhan et al. ).…”

Section: Discussionsupporting

confidence: 87%

“…For normal, glaucomatous and early glaucomatous eyes, estimated mean and estimated standard deviation (SD) for global MDB have been reported to 308 lm and 41, 171 lm and 51 and 203 lm and 44, respectively (Shieh et al 2016). Median and interquartile range for global BMO-MRW in healthy and glaucomatous eyes have been estimated to 317 lm (275-362) and 182 lm (142-218), respectively (Chauhan et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Melin

Söderberg

2019

Acta Ophthalmologica

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Purpose To estimate the sources of variation for Pigment epithelium central limit‐Inner limit of the retina Minimal Distance averaged over 2π (PIMD‐2π), and further to analyse their consequences for clinical measurements of glaucoma. Methods Forty subjects with early to moderate stage glaucoma were included. Three SD‐OCT volumes of the optic nerve head (ONH) were captured at two occasions. Each volume was segmented three times for PIMD‐2π. The magnitude of the sources of variation for PIMD‐2π measurements was estimated with an analysis of variance. Results A 95% confidence interval for mean PIMD‐2π was estimated to 215 ± 12 μm (df = 38). The estimated variance for subjects was 1280 μm2. The within‐subject estimated variance for occasions, volumes and segmentations was 10 μm2, 30 μm2 and 40 μm2, respectively. The within‐subject variances were used to model follow‐up of PIMD‐2π over time. A linear loss rate of 0.05 of baseline PIMD‐2π/year was assumed. A significant PIMD‐2π change could be detected in approximately 16–18 months with evenly spaced visits every 4 or 6 months. Conclusions Due to the small within‐subject estimated variances, a clinically undesirable PIMD‐2π change from baseline can be detected in approximately 18 months. Detection of significant PIMD‐2π loss in a subject requires knowledge of normal age loss and measurement variability.

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“…The currently estimated mean PIMD‐2 π agrees with previous measures of MDB (Shieh et al. ) and global BMO‐MRW (Chauhan et al. ).…”

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Melin

Söderberg

2019

Acta Ophthalmologica

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“…The MDB thickness was calculated by measuring the shortest distances from 100 points along the RPE/BM complex to the cup surface (Figure 1D) and has been previously described in detail by our group in recent publications. 33,34 The BMO-MRW thickness was determined from the 24 radial B-scan protocol, using the Glaucoma Premium Module software (6.0.11) seen in Figure 3. The BMO-MRW is defined by the minimum distance between the Bruch’s Membrane Opening and the ILM.…”

Section: Methodsmentioning

confidence: 99%

Enhanced Diagnostic Capability for Glaucoma of 3-Dimensional Versus 2-Dimensional Neuroretinal Rim Parameters Using Spectral Domain Optical Coherence Tomography

Fan

Tsikata

Khoueir

et al. 2017

Journal of Glaucoma

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Purpose To compare the diagnostic capability of 3-dimensional (3D) neuroretinal rim parameters with existing 2-dimensional (2D) neuroretinal and retinal nerve fiber layer (RNFL) thickness rim parameters using spectral domain optical coherence tomography (SD-OCT) volume scans Materials and Methods Design Institutional prospective pilot study. Study population 65 subjects (35 open angle glaucoma patients, 30 normal patients). Observation procedures One eye of each subject was included. SD-OCT was used to obtain 2D retinal nerve fiber layer (RNFL) thickness values and five neuroretinal rim parameters [i.e. 3D minimum distance band (MDB) thickness, 3D Bruch’s membrane opening-minimum rim width (BMO-MRW), 3D rim volume, 2D rim area, and 2D rim thickness]. Main outcome measures Area under the receiver operating characteristic (AUROC) curve values, sensitivity, specificity. Results Comparing all 3D with all 2D parameters, 3D rim parameters (MDB, BMO-MRW, rim volume) generally had higher AUROC curve values (range 0.770–0.946) compared to 2D parameters (RNFL thickness, rim area, rim thickness; range 0.678–0.911). For global region analyses, all 3D rim parameters (BMO-MRW, rim volume, MDB) were equal to or better than 2D parameters (RNFL thickness, rim area, rim thickness; p-values from 0.023–1.0). Among the three 3D rim parameters (MDB, BMO-MRW, and rim volume), there were no significant differences in diagnostic capability (false discovery rate > 0.05 at 95% specificity). Conclusion 3D neuroretinal rim parameters (MDB, BMO-MRW, and rim volume) demonstrated better diagnostic capability for primary and secondary open angle glaucomas compared to 2D neuroretinal parameters (rim area, rim thickness). Compared to 2D RNFL thickness, 3D neuroretinal rim parameters have the same or better diagnostic capability.

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“…It is likely that disc size has greater impact at the extremes, that is, for very small or very large discs or discs of highly myopic eyes . Other similar approaches based on minimum distance mapping have confirmed the advantages it provides for glaucoma diagnostics …”

Section: Current and Emerging Oct Approaches For Quantitative Evaluatmentioning

confidence: 94%

Optical coherence tomography evaluation of the optic nerve head neuro‐retinal rim in glaucoma

Fortune

2019

Clinical and Experimental Optometry

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Clinical examination of the optic disc is a fundamental component of any ophthalmic evaluation, but it is especially important for diagnosis and management of glaucoma. The purpose of this article is to: (1) review the limitations inherent to clinical examination; (2) outline the rationale for adopting into clinical practice quantitative measures of the optic nerve head neuro-retinal rim tissue integrity derived from current optical coherence tomography imaging approaches; (3) describe recent developments in this area; and (4) highlight a few avenues of active research that hold promise for future translation to clinical practice.

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Diagnostic Performance of a Novel Three-Dimensional Neuroretinal Rim Parameter for Glaucoma Using High-Density Volume Scans

Cited by 27 publications

References 49 publications

Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Variance components for PIMD‐2π estimation of the optic nerve head and consequences in clinical measurements of glaucoma

Enhanced Diagnostic Capability for Glaucoma of 3-Dimensional Versus 2-Dimensional Neuroretinal Rim Parameters Using Spectral Domain Optical Coherence Tomography

Optical coherence tomography evaluation of the optic nerve head neuro‐retinal rim in glaucoma

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