2013
DOI: 10.1186/1741-7015-11-239
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Abstract: BackgroundNon-cardiovascular chest pain (NCCP) has a high healthcare cost, but insufficient guidelines exist for its diagnostic investigation. The objective of the present work was to identify important diagnostic indicators and their accuracy for specific and non-specific conditions underlying NCCP.MethodsA systematic review and meta-analysis were performed. In May 2012, six databases were searched. Hand and bibliography searches were also conducted. Studies evaluating a diagnostic test against a reference te… Show more

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Cited by 39 publications
(45 citation statements)
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“…Some potentially life-threatening disorders are acute myocardial infarction (AMI), pericarditis, myocarditis, pulmonary embolism and aortic dissection [3]. Less severe diseases such as anxiety, gastritis and musculoskeletal injuries can also cause chest pain [4].…”
Section: Introductionmentioning
confidence: 99%
“…Some potentially life-threatening disorders are acute myocardial infarction (AMI), pericarditis, myocarditis, pulmonary embolism and aortic dissection [3]. Less severe diseases such as anxiety, gastritis and musculoskeletal injuries can also cause chest pain [4].…”
Section: Introductionmentioning
confidence: 99%
“…Our findings seem important, as pseudocardiac symptoms are often misdiagnosed [25], and a significant but neglected component of psychogenic complaints may be present even in patients with ischaemic heart disease [9,26].…”
Section: Discussionmentioning
confidence: 99%
“…The patient had a history significant for anxiety and GERD and was being treated pharmacologically for both. Gastrointestinal diseases and psychological disorders are two of the leading causes of non-cardiovascular chest pain 12. Given the patient's very low pretroponin risk profile, these non-cardiovascular causes of chest pain should have been further investigated and cardiac disease should have been much lower on the differential.…”
Section: Discussionmentioning
confidence: 99%
“…In a recent meta-analysis, Wertli et al 12 have reported that high-dose proton pump inhibitor treatment is an efficient diagnostic approach for GERD in the context of NCCP. GERD should be considered highly likely if treatment response occurs within 1 week but highly unlikely if there is no response after 4 weeks.…”
Section: Differential Diagnosismentioning
confidence: 99%
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