Diagnostic Evaluation of Neonatal Cholestasis: HIDA Scan and Alagille Criteria

Motamed, Farzaneh; Khalili, Abbas; Salamati, Payman; Moradi, Golnaz; Sani, Mehri Najafi; Kazemi, Ahmad; Fallahi, Gholamhossein; Farahmand, Fatemeh; Monajjemzadeh, Maryam

doi:10.5812/iranjradiol.6382

Cited by 1 publication

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 38 ] Motamed et al . [ 39 ] showed 60% diagnostic accuracy rate of HIDA scan for BA in their study. Conjugated bilirubin >2.5 mg/dl, GGT >150 U/L, excretion on HIDA, or a normal percutaneous cholangiogram were 100% sensitive for the exclusion of BA as demonstrated by Jancelewicz et al .…”

Section: Discussionmentioning

confidence: 92%

“…In this study, we evaluated the diagnostic accuracy of ASMA in the diagnosis of EHBA and INH, and according to our results, the sensitivity, specificity, PPV, NPV and accuracy of SMA in differentiating cases with BA were 66.7%, 75%, 80%, 60% and 70%, respectively. Compared with the accuracy rates of invasive procedures (MRCP [71.1%], HBS [66.7%], HIDA scan [60%] and ultrasonography [69.2%]),[ 33 38 39 ] ASMA may be a useful marker for the differentiation of EHBA from INH.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic value of anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis

Rafeey

Saboktakin

Hasani

et al. 2016

Afr J Paediatr Surg

View full text Add to dashboard Cite

Background:We aimed to evaluate the diagnostic value of anti-smooth muscle antibodies (ASMA) and two liver markers (gamma-glutamyl transpeptidase [GGT] and alkaline phosphatase [ALP]) for differentiating between patients with extrahepatic biliary atresia (EHBA) and idiopathic neonatal hepatitis (INH).Materials and Methods:During April 2010–2011, all infants at 2 weeks of age who were diagnosed with cholestasis and admitted to Children's Hospital of Tabriz were enrolled. Based on the results of physical examination, laboratory, imaging and pathological studies, neonates were divided into two groups (EHBA and INH). Receiver operating characteristics analysis was used to define sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for ASMA, GGT and ALP.Results:Thirty neonates with cholestasis (18 with EHBA and 12 with INH) and mean age of 54.66 ± 25.86 days were enrolled. Total and direct bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase and ASMA titres were highly not significant (P > 0.05) in patients with INH. GGT (P = 0.008) and ALP (P = 0.01) had statistically significant differences that were higher in patients with EHBA. The sensitivity, specificity, PPV and NPV, accuracy, LR+ and LR− of SMA in differentiating cases with BA were 66.7%, 75%, 80% 60%, 70%, 2.68 and 0.44, respectively. For GGT, the values were 88.9%, 66.7%, 80%, 80%, 79.1%, 3.08 and 0.31, respectively. Finally, for ALP, the values were 77.8%, 75%, 82.4%, 69.2%, 80%, 2.66 and 0.24, respectively.Conclusion:Our study showed that ASMA may be a useful biomarker for differentiation of EHBA from INH. Further studies with larger samples are recommended for confirming the results of this study.

show abstract

Section: Discussionmentioning

confidence: 92%