Diagnostic differentiation between reactive and malignant lymphoid cells in serous effusions

Cytomorphological and immunocytochemical study of non‐Hodgkin's lymphoma in pleural effusion and ascitic fluid

“…Among 45 cytologically proven malignant ascites cases, Malik et al 11 reported primary ovarian malignancy in 47%, NHL in 11% and bladder carcinoma in 9%. According to Johnson et al, 14 reactive lymphocytes were the predominant cell types in effusions associated with benign conditions and non-haemopoietic malignancies, while a significant proportion of effusions from lymphoma cases showed unequivocal evidence of involvement. 3 In our material, 291 (7.9%) of the 3336 pleural effusion and ascitic fluid samples were malignant or suspicious for malignancy.…”

“…1 As regards the role of exfoliative cytology in the diagnosis of lymphomas, Billingham et al 13 were of the opinion that it is an accurate method for diagnosing lymphomatous involvement of body cavities, and when a cytological diagnosis of lymphoma is made, it is almost as accurate as histological diagnosis. According to Johnson et al, 14 reactive lymphocytes were the predominant cell types in effusions associated with benign conditions and non-haemopoietic malignancies, while a significant proportion of effusions from lymphoma cases showed unequivocal evidence of involvement. Lymphomatous involvement in pleural effusion has variously been classified using the Rappaport's morphological classification, 15 Luke and Col-linsÕ functional classification, 4 the Working formulation, 16 there are a few studies on categorization of lymphoid neoplasia in FNA cytology material based on the REAL, 18-20 REAL/WHO, 21 and WHO classification, 22,23 there is hardly any study of lymphomatous effusions using the REAL or WHO classifications.…”

Cytomorphological and immunocytochemical study of non‐Hodgkin's lymphoma in pleural effusion and ascitic fluid

“…Among 45 cytologically proven malignant ascites cases, Malik et al 11 reported primary ovarian malignancy in 47%, NHL in 11% and bladder carcinoma in 9%. According to Johnson et al, 14 reactive lymphocytes were the predominant cell types in effusions associated with benign conditions and non-haemopoietic malignancies, while a significant proportion of effusions from lymphoma cases showed unequivocal evidence of involvement. 3 In our material, 291 (7.9%) of the 3336 pleural effusion and ascitic fluid samples were malignant or suspicious for malignancy.…”

“…1 As regards the role of exfoliative cytology in the diagnosis of lymphomas, Billingham et al 13 were of the opinion that it is an accurate method for diagnosing lymphomatous involvement of body cavities, and when a cytological diagnosis of lymphoma is made, it is almost as accurate as histological diagnosis. According to Johnson et al, 14 reactive lymphocytes were the predominant cell types in effusions associated with benign conditions and non-haemopoietic malignancies, while a significant proportion of effusions from lymphoma cases showed unequivocal evidence of involvement. Lymphomatous involvement in pleural effusion has variously been classified using the Rappaport's morphological classification, 15 Luke and Col-linsÕ functional classification, 4 the Working formulation, 16 there are a few studies on categorization of lymphoid neoplasia in FNA cytology material based on the REAL, 18-20 REAL/WHO, 21 and WHO classification, 22,23 there is hardly any study of lymphomatous effusions using the REAL or WHO classifications.…”

An aggressive form of non-Hodgkin's lymphoma with pleural and abdominal chylous effusions: A case report and review of the literature

“…Das et al compared fine-needle aspiration cytology with pleural effusion cytological studies and identified that in 93.7% of the cases, the cytological findings matched the diagnosis (8). Following the development of new techniques and our improved understanding of biomarkers, immunochemistry, FCM and cytogenetics are being widely used to aid in obtaining a fast and precise diagnosis (14,15). In the present study, a thoracocentesis and a paracentesis were performed.…”

Chylous Effusions (Pleural Effusion and Ascites) due to Non-Hodgkin’s Lymphoma A Case Report

“…11 Following development of biomarkers , immunohistochemistry and cytogenetics the rate fast and precise diagnosis has increased. 12 In the current study, pleural and ascetic uid were aspirated but only ascetic uid was studied which showed whitish hazy exudative uid that had high lymphocyte count and high TG level( 560 mg/dl) and negative for malignant cells and it was a co rm case of chylous ascites. e lymphnode biopsy showed -Non Hodgkin's lymphoma.…”

Cytomorphological and immunocytochemical study of non‐Hodgkin's lymphoma in pleural effusion and ascitic fluid

“…Among 45 cytologically proven malignant ascites cases, Malik et al 11 reported primary ovarian malignancy in 47%, NHL in 11% and bladder carcinoma in 9%. According to Johnson et al, 14 reactive lymphocytes were the predominant cell types in effusions associated with benign conditions and non-haemopoietic malignancies, while a significant proportion of effusions from lymphoma cases showed unequivocal evidence of involvement. 3 In our material, 291 (7.9%) of the 3336 pleural effusion and ascitic fluid samples were malignant or suspicious for malignancy.…”

“…1 As regards the role of exfoliative cytology in the diagnosis of lymphomas, Billingham et al 13 were of the opinion that it is an accurate method for diagnosing lymphomatous involvement of body cavities, and when a cytological diagnosis of lymphoma is made, it is almost as accurate as histological diagnosis. According to Johnson et al, 14 reactive lymphocytes were the predominant cell types in effusions associated with benign conditions and non-haemopoietic malignancies, while a significant proportion of effusions from lymphoma cases showed unequivocal evidence of involvement. Lymphomatous involvement in pleural effusion has variously been classified using the Rappaport's morphological classification, 15 Luke and Col-linsÕ functional classification, 4 the Working formulation, 16 there are a few studies on categorization of lymphoid neoplasia in FNA cytology material based on the REAL, 18-20 REAL/WHO, 21 and WHO classification, 22,23 there is hardly any study of lymphomatous effusions using the REAL or WHO classifications.…”

An aggressive form of non-Hodgkin's lymphoma with pleural and abdominal chylous effusions: A case report and review of the literature

“…Das et al compared fine-needle aspiration cytology with pleural effusion cytological studies and identified that in 93.7% of the cases, the cytological findings matched the diagnosis (8). Following the development of new techniques and our improved understanding of biomarkers, immunochemistry, FCM and cytogenetics are being widely used to aid in obtaining a fast and precise diagnosis (14,15). In the present study, a thoracocentesis and a paracentesis were performed.…”

Chylous Effusions (Pleural Effusion and Ascites) due to Non-Hodgkin’s Lymphoma A Case Report

“…11 Following development of biomarkers , immunohistochemistry and cytogenetics the rate fast and precise diagnosis has increased. 12 In the current study, pleural and ascetic uid were aspirated but only ascetic uid was studied which showed whitish hazy exudative uid that had high lymphocyte count and high TG level( 560 mg/dl) and negative for malignant cells and it was a co rm case of chylous ascites. e lymphnode biopsy showed -Non Hodgkin's lymphoma.…”

Cytomorphological and immunocytochemical study of non‐Hodgkin's lymphoma in pleural effusion and ascitic fluid

“…Among 45 cytologically proven malignant ascites cases, Malik et al 11 reported primary ovarian malignancy in 47%, NHL in 11% and bladder carcinoma in 9%. According to Johnson et al, 14 reactive lymphocytes were the predominant cell types in effusions associated with benign conditions and non-haemopoietic malignancies, while a significant proportion of effusions from lymphoma cases showed unequivocal evidence of involvement. 3 In our material, 291 (7.9%) of the 3336 pleural effusion and ascitic fluid samples were malignant or suspicious for malignancy.…”

“…1 As regards the role of exfoliative cytology in the diagnosis of lymphomas, Billingham et al 13 were of the opinion that it is an accurate method for diagnosing lymphomatous involvement of body cavities, and when a cytological diagnosis of lymphoma is made, it is almost as accurate as histological diagnosis. According to Johnson et al, 14 reactive lymphocytes were the predominant cell types in effusions associated with benign conditions and non-haemopoietic malignancies, while a significant proportion of effusions from lymphoma cases showed unequivocal evidence of involvement. Lymphomatous involvement in pleural effusion has variously been classified using the Rappaport's morphological classification, 15 Luke and Col-linsÕ functional classification, 4 the Working formulation, 16 there are a few studies on categorization of lymphoid neoplasia in FNA cytology material based on the REAL, 18-20 REAL/WHO, 21 and WHO classification, 22,23 there is hardly any study of lymphomatous effusions using the REAL or WHO classifications.…”

An aggressive form of non-Hodgkin's lymphoma with pleural and abdominal chylous effusions: A case report and review of the literature

“…Das et al compared fine-needle aspiration cytology with pleural effusion cytological studies and identified that in 93.7% of the cases, the cytological findings matched the diagnosis (8). Following the development of new techniques and our improved understanding of biomarkers, immunochemistry, FCM and cytogenetics are being widely used to aid in obtaining a fast and precise diagnosis (14,15). In the present study, a thoracocentesis and a paracentesis were performed.…”

Chylous Effusions (Pleural Effusion and Ascites) due to Non-Hodgkin’s Lymphoma A Case Report

“…11 Following development of biomarkers , immunohistochemistry and cytogenetics the rate fast and precise diagnosis has increased. 12 In the current study, pleural and ascetic uid were aspirated but only ascetic uid was studied which showed whitish hazy exudative uid that had high lymphocyte count and high TG level( 560 mg/dl) and negative for malignant cells and it was a co rm case of chylous ascites. e lymphnode biopsy showed -Non Hodgkin's lymphoma.…”