Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia

Ahmed, Anwar

doi:10.1016/j.ijid.2017.07.008

Cited by 20 publications

(27 citation statements)

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“…The diagnosis of this infection remains complex (Al Johani and Hajeer, 2016;Sung et al, 2016;Ahmed, 2017a) and it has a high fatality rate (Ahmed, 2017b, c;Aleanizy et al, 2017;Sherbini et al, 2017;Kim et al, 2017). The early detection and identification of individuals at high risk of a disease is the most effective strategy to improve patient clinical outcomes (Ahmed, 2017a) and reduce the costs of testing, both physical and economic (Ahmed et al, 2011(Ahmed et al, , 2013. The real-time reverse transcription polymerase chain reaction (rRT-PCR) has been found to be valid and accurate for the evaluation of respiratory swabs, sputum, and other endotracheal aspirate material (Corman et al, 2012a, b).…”

Section: Introductionmentioning

confidence: 99%

Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia

Ahmed

Al-Jahdali

Alshukairi

et al. 2018

International Journal of Infectious Diseases

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Section: Introductionmentioning

confidence: 99%

Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia

Ahmed

Al-Jahdali

Alshukairi

et al. 2018

International Journal of Infectious Diseases

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“…In our study, patients with respiratory symptoms are more likely to experience shorter recovery delay than patients without respiratory symptoms. This finding is probably related to the shorter lag time between symptom onset and diagnosis, in which patients with presence of symptoms could be positively affected by an early diagnosis and thus prompt medical support is deemed necessary.…”

Section: Discussionmentioning

confidence: 98%

“…The time interval from presentation to initial rRT‐PCR diagnosis (diagnosis delay) was positively correlated with the time interval from initial rRT‐PCR diagnosis to recovery (recovery delay). Early diagnosis is likely to improve clinical outcomes and reduce the economic and physical burden of a disease . Early diagnosis requires full utilization of hospital resources.…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with recovery delay in a sample of patients diagnosed by MERS‐CoV rRT‐PCR: A Saudi Arabian multicenter retrospective study

Ahmed

Al‐Jahdali

Alaqeel

et al. 2018

Influenza Resp Viruses

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BackgroundResearch evidence exists that poor prognosis is common in Middle East respiratory syndrome coronavirus (MERS‐CoV) patients.ObjectivesThis study estimates recovery delay intervals and identifies associated factors in a sample of Saudi Arabian patients admitted for suspected MERS‐CoV and diagnosed by rRT‐PCR assay.MethodsA multicenter retrospective study was conducted on 829 patients admitted between September 2012 and June 2016 and diagnosed by rRT‐PCR procedures to have MERS‐CoV and non‐MERS‐CoV infection in which 396 achieved recovery. Detailed medical charts were reviewed for each patient who achieved recovery. Time intervals in days were calculated from presentation to the initial rRT‐PCR diagnosis (diagnosis delay) and from the initial rRT‐PCR diagnosis to recovery (recovery delay).ResultsThe median recovery delay in our sample was 5 days. According to the multivariate negative binomial model, elderly (age ≥ 65), MERS‐CoV infection, ICU admission, and abnormal radiology findings were associated with longer recovery delay (adjusted relative risk (aRR): 1.741, 2.138, 2.048, and 1.473, respectively). Camel contact and the presence of respiratory symptoms at presentation were associated with a shorter recovery delay (expedited recovery) (aRR: 0.267 and 0.537, respectively). Diagnosis delay is a positive predictor for recovery delay (r = .421; P = .001).ConclusionsThe study evidence supports that longer recovery delay was seen in patients of older age, MERS‐CoV infection, ICU admission, and abnormal radiology findings. Shorter recovery delay was found in patients who had camel contact and respiratory symptoms at presentation. These findings may help us understand clinical decision making on directing hospital resources toward prompt screening, monitoring, and implementing clinical recovery and treatment strategies.

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“…The death rate among healthcare workers is negligible. This is due to increased infection awareness, early diagnosis and protective measures taken [26]. The univariate analysis of survival yields the result that gender is a significant factor and male are more likely to die.…”

Section: Discussionmentioning

confidence: 99%

Main factors influencing recovery in MERS Co-V patients using machine learning

John

Shaiba

2019

Journal of Infection and Public Health

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a b s t r a c tBackground: Middle East Respiratory Syndrome (MERS) is a major infectious disease which has affected the Middle Eastern countries, especially the Kingdom of Saudi Arabia (KSA) since 2012. The high mortality rate associated with this disease has been a major cause of concern. This paper aims at identifying the major factors influencing MERS recovery in KSA. Methods: The data used for analysis was collected from the Ministry of Health website, KSA. The important factors impelling the recovery are found using machine learning. Machine learning models such as support vector machine, conditional inference tree, naïve Bayes and J48 are modelled to identify the important factors. Univariate and multivariate logistic regression analysis is also carried out to identify the significant factors statistically. Result: The main factors influencing MERS recovery rate are identified as age, pre-existing diseases, severity of disease and whether the patient is a healthcare worker or not. In spite of MERS being a zoonotic disease, contact with camels is not a major factor influencing recovery. Conclusion: The methods used were able to determine the prime factors influencing MERS recovery. It can be comprehended that awareness about symptoms and seeking medical intervention at the onset of development of symptoms will make a long way in reducing the mortality rate.

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Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia

Cited by 20 publications

References 20 publications

Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia

Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia

Factors associated with recovery delay in a sample of patients diagnosed by MERS‐CoV rRT‐PCR: A Saudi Arabian multicenter retrospective study

Main factors influencing recovery in MERS Co-V patients using machine learning

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