“…sleep disorders, loss of appetite), which can be related not only to depression, but also to the medical illness itself and that could unjustifiably increase the score, leading to an overestimation of depression. To date, no definitive conclusions have been drawn regarding the best cut-off value for the depressive subscales of the HADS (HADS-D) [6], [7] and [8]. Recently, Bunevicius and colleagues suggested that "5" was the best cut-off for screening for Major Depressive Episodes (MDE) in Coronary Artery Disease (CAD) patients who are undergoing cardiac rehabilitation [6].…”