Diagnostic accuracy of PET/CT in patients with extranodal marginal zone MALT lymphoma

Perry, Chava; Herishanu, Yair; Metzer, Ur; Bairey, Osnat; Ruchlemer, Rosa; Trejo, Leonor; Naparstek, Elizabeth; Sapir, Einav; Polliack, Aaron

doi:10.1111/j.1600-0609.2007.00895.x

Cited by 124 publications

(151 citation statements)

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“…MALT marginal zone lymphoma demonstrated an 18 F-FDG avidity of 54%, an incidence that is at the lower limit of the previously reported wide range of 55%282% (10,(16)(17)(18)(19). These different results may be due both to the small number of studied patients that were included in most of the previous reports and to a possible difference in the location of disease in the various series.…”

Section: Discussionmentioning

confidence: 70%

“…Although most lymphoma subtypes have been shown to be highly avid for 18 F-FDG, a lower 18 F-FDG avidity has been reported for lymphoma subtypes such as small lymphocytic lymphoma (7), peripheral T-cell lymphoma (5), anaplastic large T-cell lymphoma (8), and extranodal marginal zone lymphomas, including the mucosa-associated lymphoid tissue (MALT) marginal zone lymphoma (9,10) and splenic marginal zone lymphoma (6).…”

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confidence: 99%

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¹⁸F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients

Weiler-Sagie¹,

Bushelev²,

Epelbaum³

et al. 2009

J Nucl Med

347

189

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Section: Discussionmentioning

confidence: 70%

mentioning

confidence: 99%

¹⁸F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients

Weiler-Sagie¹,

Bushelev²,

Epelbaum³

et al. 2009

J Nucl Med

347

189

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“…Although of lesser relevance, 18F-FDG-PET/CT is also cost intensive, and because most PET/CT devices are installed at metropolitan tertiary care centers, country-wide access is limited. Furthermore, certain lymphoma subtypes, such as extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT), are frequently not FDG-avid (1,(7)(8)(9)(10), and thus, 18F-FDG-PET/CT is generally not recommended in these cases (11). In the latter lymphoma subtypes, contrast-enhanced (CE) CT, which relies exclusively on morphology, is therefore the standard imaging test, because no functional technique has been established so far.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Diffusion-Weighted MRI for Pretherapeutic Assessment and Staging of Lymphoma: Results of a Prospective Study in 140 Patients

Mayerhoefer

Karanikas

Kletter

et al. 2014

Clinical Cancer Research

100

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Purpose: To determine the value of diffusion-weighted MRI (DWI-MRI) for pretherapeutic imaging of fluorodeoxyglucose (FDG)-avid lymphoma and lymphoma with variable FDG avidity.Experimental Design: Treatment-na€ ve patients with lymphoma who were referred for whole-body staging were included in this prospective study. Group A included patients with FDG-avid lymphoma (e.g., Hodgkin, diffuse large B-cell, and follicular lymphoma), whereas Group B included patients with lymphoma of variable FDG avidity [e.g., extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT)]. All patients underwent DWI-MRI and 18F-FDG-positron emission tomography/ computed tomography (PET/CT). Region-based sensitivity and agreement with Ann Arbor staging, relative to the reference standard, were calculated for DWI-MRI, and, in Group B, also 18F-FDG-PET/CT and contrast-enhanced (CE-) CT.Results: In Group A (100 patients), DWI-MRI had a region-based sensitivity of 97%, and with regard to staging, agreed with the reference standard in 94 of 100 patients (k, 0.92). In Group B (40 patients; 38 MALT lymphomas and 2 small lymphocytic lymphomas/chronic lymphocytic leukemias), DWI-MRI, 18F-FDG-PET/CT, and CE-CT had region-based sensitivities of 94.4%, 60.9%, and 70.7%, respectively. With regard to staging in Group B, DWI-MRI, 18F-FDG-PET/CT, and CE-CT agreed with the reference standard in 37 of 40, 26 of 40, and 24 of 40 patients, with k values of 0.89, 0.52, and 0.43, respectively.Conclusions: In patients with FDG-avid lymphoma, DWI-MRI seems to be only slightly inferior to 18F-FDG-PET/CT with regard to pretherapeutic regional assessment and staging. In patients with lymphoma subtypes that show a variable FDG avidity (e.g., MALT lymphoma), DWI-MRI seems to be superior to both 18F-FDG-PET/CT and CE-CT. Clin Cancer Res; 20(11); 2984-93. Ó2014 AACR.

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“…Many investigations support the importance of the PET findings to diagnose and follow up MALTOMA. But PET uptake of the tumor can be changed according the primary location [16,17]. Surgical removal of the tumor depends on the location of the parotid mass.…”

Section: Discussionmentioning

confidence: 99%

Extranodal Marginal Zone Lymphoma of the Parotid Gland

Aydın

Demir

Barışık

2016

J. Maxillofac. Oral Surg.

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Non Hodgkin lymphomas correspond to 25 % of all head and neck cancers. These rare tumors only include less than 5 % of malign tumors in parotid region. Differential diagnosis of these tumors cover many malign and benign tumors of the parotid gland. Definite diagnosis depends on sufficient tissue material of parotidectomy specimen. Treatment modality is surgical removal of the lesion with or without additional radiation and chemotherapy depending on the stage of the tumor. Prognosis is better than other forms of the B-cell lymphoma. We present a 54 year old woman who suffered from progressively and slowly growing mass on parotid region, without any inflammatory disease or chronic infection, diagnosed with mucosa associated lymphoid tissue lymphoma of the parotid gland. Parotid gland was totally excised by superficial parotidectomy and there is no recurrence after 5 years postoperative period.

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Diagnostic accuracy of PET/CT in patients with extranodal marginal zone MALT lymphoma

Abstract: These data suggest that PET/CT is a useful tool for both, initial staging and follow-up after therapy in patients with MALT lymphoma. Its sensitivity depends on disease location and stage at initial diagnosis.

Cited by 124 publications

References 10 publications

¹⁸F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients

¹⁸F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients

Evaluation of Diffusion-Weighted MRI for Pretherapeutic Assessment and Staging of Lymphoma: Results of a Prospective Study in 140 Patients

Extranodal Marginal Zone Lymphoma of the Parotid Gland

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Diagnostic accuracy of PET/CT in patients with extranodal marginal zone MALT lymphoma

Abstract: These data suggest that PET/CT is a useful tool for both, initial staging and follow-up after therapy in patients with MALT lymphoma. Its sensitivity depends on disease location and stage at initial diagnosis.

Cited by 124 publications

References 10 publications

18F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients

18F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients

Evaluation of Diffusion-Weighted MRI for Pretherapeutic Assessment and Staging of Lymphoma: Results of a Prospective Study in 140 Patients

Extranodal Marginal Zone Lymphoma of the Parotid Gland

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¹⁸F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients

¹⁸F-FDG Avidity in Lymphoma Readdressed: A Study of 766 Patients