Diagnostic Accuracy of Follow-Up FDG PET or PET/CT in Patients With Head and Neck Cancer After Definitive Treatment: A Systematic Review and Meta-Analysis

Sheikhbahaei, Sara; Taghipour, Mehdi; Ahmad, Rubina; Fakhry, Carole; Kiess, Ana P.; Chung, Christine H.; Subramaniam, Rathan M.

doi:10.2214/ajr.14.14166

Cited by 90 publications

(62 citation statements)

References 41 publications

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“…7,9 Postoperative followup with PET/CT enables early detection of tumor recurrence, guides endoscopic biopsies, and allows selection of treatment for better survival and lower morbidity of those patients. 7,9 Postoperative followup with PET/CT enables early detection of tumor recurrence, guides endoscopic biopsies, and allows selection of treatment for better survival and lower morbidity of those patients.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8][9][10][11] An important advantage of PET/CT is that a whole-body scan allows for the detection of distant metastases and unexpected secondary cancers. Positron emission tomography (PET) and, in particular, combined PET-computed tomography (PET/CT) have become popular as useful diagnostic and prognostic tools for pretreatment staging, radiotherapy planning, measuring treatment response for residual or recurrent disease, and monitoring posttreatment follow-up results in various head and neck malignancies.…”

Section: Introductionmentioning

confidence: 99%

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Utility of first positron emission tomography‐computed tomography scan as a prognostic tool following treatment of sinonasal and skull base malignancies

et al. 2018

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Background The prognostic value of the first posttreatment whole body integrated positron emission tomography‐computed tomography (PET/CT) scanning in patients with sinonasal/skull base malignancies is undetermined. Methods We retrospectively reviewed the data of all patients that underwent surgery for sinonasal/skull base malignancies in 2000‐2015. The results of the pretreatment and posttreatment PET/CT findings and the clinical course were retrieved. Results Thirty‐eight patients (average age 60.6 years, 20 males) were included. Sensitivity and specificity, positive predictive value, and negative predictive value of the first PET/CT scan for predicting persistent/recurrent disease were 85.7%, 87.5%, 80%, and 91.3%, respectively. Overall 5‐year survival was significantly lower in the first posttreatment PET/CT‐positive group (35%) compared to the PET/CT‐negative group (93%) (P = .0008). Conclusion Posttreatment PET/CT findings are highly prognostic in patients with sinonasal/skull base malignancies. Negative findings on the first posttreatment PET/CT scan predict a significantly better overall survival.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Utility of first positron emission tomography‐computed tomography scan as a prognostic tool following treatment of sinonasal and skull base malignancies

et al. 2018

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“…To support this hypothesis, our team has already shown in several series the high performance of FDG‐PET/CT to diagnose subclinical relapse with an overall accuracy varying from 89% to 97% . Furthermore, a recent meta‐analysis of seven studies comprising 920 patients without clinical symptoms also revealed respective pooled sensitivity and specificity of 89% and 90%, respectively, of FDG‐PET/CT in detecting asymptomatic recurrence after treatment . However, we admit that comparing TNR PET and contrast enhancement is not completely relevant, but we did not find any other quantitative value to compare.…”

Section: Discussionmentioning

confidence: 74%

Diagnostic performance of ¹⁸fluorodesoxyglucose positron emission/computed tomography and magnetic resonance imaging in detecting T1‐T2 head and neck squamous cell carcinoma

et al. 2017

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“…FDG-PET is frequently used for treatment response assessment with high sensitivity but lower specificity [45]. Compared to FDG-PET, ADC can be performed earlier to assess treatment response.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of magnetic resonance imaging techniques for treatment response evaluation in patients with head and neck tumors, a systematic review and meta-analysis

et al. 2017

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BackgroundNovel advanced MRI techniques are investigated in patients treated for head and neck tumors as conventional anatomical MRI is unreliable to differentiate tumor from treatment related imaging changes.PurposeAs the diagnostic accuracy of MRI techniques to detect tumor residual or recurrence during or after treatment is variable reported in the literature, we performed a systematic meta-analysis.Data sourcesPubmed, EMBASE and Web of Science were searched from their first record to September 23th 2014.Study selectionStudies reporting diagnostic accuracy of anatomical, ADC, perfusion or spectroscopy to identify tumor response confirmed by histology or follow-up in treated patients for head and neck tumors were selected by two authors independently.Data analysisTwo authors independently performed data extraction including true positives, false positives, true negatives, false negatives and general study characteristics. Meta-analysis was performed using bivariate random effect models when ≥5 studies per test were included.Data synthesisWe identified 16 relevant studies with anatomical MRI and ADC. No perfusion or spectroscopy studies were identified. Pooled analysis of anatomical MRI of the primary site (11 studies, N = 854) displayed a sensitivity of 84% (95%CI 72–92) and specificity of 82% (71–89). ADC of the primary site (6 studies, N = 287) showed a pooled sensitivity of 89% (74–96) and specificity of 86% (69–94).LimitationsMain limitation are the low, but comparable quality of the included studies and the variability between the studies.ConclusionsThe higher diagnostic accuracy of ADC values over anatomical MRI for the primary tumor location emphases the relevance to include DWI with ADC for response evaluation of treated head and neck tumor patients.

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Diagnostic Accuracy of Follow-Up FDG PET or PET/CT in Patients With Head and Neck Cancer After Definitive Treatment: A Systematic Review and Meta-Analysis

Cited by 90 publications

References 41 publications

Utility of first positron emission tomography‐computed tomography scan as a prognostic tool following treatment of sinonasal and skull base malignancies

Utility of first positron emission tomography‐computed tomography scan as a prognostic tool following treatment of sinonasal and skull base malignancies

Diagnostic performance of ¹⁸fluorodesoxyglucose positron emission/computed tomography and magnetic resonance imaging in detecting T1‐T2 head and neck squamous cell carcinoma

Diagnostic accuracy of magnetic resonance imaging techniques for treatment response evaluation in patients with head and neck tumors, a systematic review and meta-analysis

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Diagnostic Accuracy of Follow-Up FDG PET or PET/CT in Patients With Head and Neck Cancer After Definitive Treatment: A Systematic Review and Meta-Analysis

Cited by 90 publications

References 41 publications

Utility of first positron emission tomography‐computed tomography scan as a prognostic tool following treatment of sinonasal and skull base malignancies

Utility of first positron emission tomography‐computed tomography scan as a prognostic tool following treatment of sinonasal and skull base malignancies

Diagnostic performance of 18fluorodesoxyglucose positron emission/computed tomography and magnetic resonance imaging in detecting T1‐T2 head and neck squamous cell carcinoma

Diagnostic accuracy of magnetic resonance imaging techniques for treatment response evaluation in patients with head and neck tumors, a systematic review and meta-analysis

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Diagnostic performance of ¹⁸fluorodesoxyglucose positron emission/computed tomography and magnetic resonance imaging in detecting T1‐T2 head and neck squamous cell carcinoma