Diagnosis of Pulmonary Emphysema by Computerised Tomography

Hayhurst, M D; Flenley, D. C.; McLean, Andrew N.; Wightman, A. J. A.; MacNee, William; Wright, David W.; Lamb, D; Best, J. J. K.

doi:10.1016/s0140-6736(84)92689-8

Cited by 253 publications

(153 citation statements)

References 5 publications

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“…Decreased expiratory flow in COPD is related to a combination of loss of lung elastic recoil and small airway obstruction. The pathological lesion that is best correlated with loss of lung recoil is emphysema, and CT scanning has been used extensively to detect and quantify emphysema [92][93][94]. Quantification of the airway lesions by CT has received less attention, but improvements in CT technology now make it possible to detect and quantify the airway abnormalities in these patients.…”

Section: Airway Imaging In Copdmentioning

confidence: 99%

Computed tomographic imaging of the airways: relationship to structure and function

Jong

Müller²,

Paré³

et al. 2005

European Respiratory Journal

156

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Alterations in the structure of the airways, collectively termed airway remodelling, contribute to airflow obstruction in a variety of chronic lung diseases. While histology has provided valuable insights into the structure of airway wall remodelling, this technique is invasive and does not allow the longitudinal analysis of airway wall dimensions. Technical advances in computed tomography allow the assessment of airway wall dimensions, and are ideally suited for the noninvasive investigation of the pathogenesis of airway wall remodelling and the evaluation of new therapeutic interventions. The aim of this article is to review the use of computed tomography in the investigation of airway structure and function in health and disease.

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Section: Airway Imaging In Copdmentioning

confidence: 99%

Computed tomographic imaging of the airways: relationship to structure and function

Jong

Müller²,

Paré³

et al. 2005

European Respiratory Journal

156

View full text Add to dashboard Cite

show abstract

“…[12][13][14] Although CT scanning provides a method of quantifying the size and extent of emphysema within the lungs of living subjects, no single method of CT assessment is universally accepted by all investigators. Emphysema has been quantified using the lowest fifth percentile of the radiographic attenuation distribution, 30 a "density mask" cut off of attenuation values, 23 and by expansion of the lung volume beyond normal, 19 but none of these techniques quantifies the size of the lesions. Recent attempts to quantify the distribution of emphysema have focused on the relative proportion of upper versus lower 25 and/or central versus peripheral 15 emphysema.…”

Section: Discussionmentioning

confidence: 99%

Chronic obstructive pulmonary disease

Kutty

Varkey²

1988

Postgraduate Medicine

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“…Obvious fibrosis is not present [ATS 1987[ATS , 1995Barnhart 1994;Becklake 1992], although small emphysematous spaces are frequently seen radiographically around the edges of large silicotic masses [Weill et al 1994]. The diagnosis of emphysema is defined by pathologic criteria, and more recently by the presence of avascular spaces on computed tomographic (CT) scans of the lung [Barnhart 1994;Hayhurst et al 1984]. Clinical signs include hyperinflation on chest radiographs, increased total lung capacity, reduced FEV 1 , reduced diffusing capacity for carbon monoxide (DLCO) [Barnhart 1994], and weight loss [Stulbarg and Zimmerman 1996].…”

Section: Definitionmentioning

confidence: 99%