Diagnosis of Plasmodium falciparum infections in mummies using the rapid manual ParaSight™-F test

Miller, Robert L.; Ikram, Salma; Armelagos, George J.; Walker, Roxie; Harer, W. Benson; Shiff, Clive; Baggett, David W.; Carrigan, M. J.; Maret, Stéphanie

doi:10.1016/0035-9203(94)90484-7

Cited by 110 publications

(53 citation statements)

References 13 publications

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“…Although HRP2 provides better sensitivity than pLDH, it has problems with false-positive results because of its persistence in the circulatory system after parasite death. [33][34][35][36][37] In this study, the detection threshold of our RDT for P. vivax -positive samples was similar to that of NanoSign™ Malaria Pf/Pan Ag but higher than that of BioLine Malaria Pf/Pan Ag. These results might be caused by the difference in immunoreactivity of the pLDH antigens.…”

Section: Discussionsupporting

confidence: 59%

Development and Evaluation of a Rapid Diagnostic Test for Plasmodium falciparum, P. vivax, and Mixed-Species Malaria Antigens

Lee

Jeon²,

Le³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Abstract. Plasmodium falciparum and P. vivax malaria are endemic to many parts of the world and humans can be co-infected with both species. Because each Plasmodium species has different biological and clinical characteristics, accurate differentiation of the infecting species is essential for effective treatment. Therefore, we produced three monoclonal antibodies that recognize the lactate dehydrogenase of P. falciparum , P. vivax , or both to develop the first P. falciparum , P. vivax , and mixed-species infections malaria antigen detection kit. The detection limits of this kit were 150 and 250 parasites/µL for P. falciparum and P. vivax , respectively, and the kit was able to detect mixed-species infections. The sensitivity and specificity of this kit was assessed with 722 clinical specimens. Our results showed that its sensitivities for P. falciparum , P. vivax , and mixed-species infection were 96.5%, 95.3%, and 85.7%, respectively. In addition, its specificity was high (99.4%).

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Section: Discussionsupporting

confidence: 59%

Development and Evaluation of a Rapid Diagnostic Test for Plasmodium falciparum, P. vivax, and Mixed-Species Malaria Antigens

Lee

Jeon²,

Le³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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“…Several Egyptian mummies have been tested for malaria, whereby positive reactions, indicative of falciparum antigens, was found in 7 out of 18 mummies (Miller et al, 1994). A similar frequency (40%) was reported by Cerutti et al (1999Cerutti et al ( , 2005, when they investigated 135 mummies from the Gebelen site in Egypt.…”

Section: Parasitic Diseasessupporting

confidence: 65%

Mummies

Lynnerup

2007

Am. J. Phys. Anthropol.

165

115

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Mummies are human remains with preservation of nonbony tissue. Mummification by natural influences results in so-called natural mummies, whereas mummification induced by active (human) intervention results in so-called artificial mummies, although many cultures practiced burial rites, which to some degree involved both natural and artificial mummification. Since they are so uniquely well-preserved, mummies may give many insights into mortuary practices and burial rites. Specifically, the presence of soft tissues may expand the scope of paleopathological studies. Many recent mummy studies focus on the development and application of nondestructive methods for examining mummies, including radiography, CT-scanning with advanced three-dimensional visualizations, and endoscopic techniques, as well as minimally-destructive chemical, physical, and biological methods for, e.g., stable isotopes, trace metals, and DNA. This article discusses mummification and gives a presentation of various key mummy finds and a brief history of mummy studies. A description of the extant key technologies of natural and medical science that are applied in mummy studies is given; along with a discussion of some of the major results in terms of paleopathology. It is also shown how mummy studies have contributed much to the knowledge of the cultural habits and everyday life of past populations. Finally the impact of mummy studies on analyses of mortuary practices and cultural history is discussed. Yrbk Phys Anthropol 50: 162-190, 2007. V

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“…Les résultats de cette étude, s'ajoutent à ceux de travaux antérieurs réalisés pour détecter des unicellulaires sanguins, Plasmodium falciparum (Miller et al, 1994 ;Cerruti et al, 1999), Trypanosoma cruzi (Fornaciari et al, 1992) et des helminthes, Schistosoma sp. (Deelder et al, 1990 ;Miller et al, 1992).…”

Section: Discussionunclassified

Paléoparasitologie et immunologie. L’exemple d’Entamoeba histolytica

Bailly¹,

Bouchet²

2006

archeosciences

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Diagnosis of Plasmodium falciparum infections in mummies using the rapid manual ParaSight™-F test

Cited by 110 publications

References 13 publications

Development and Evaluation of a Rapid Diagnostic Test for Plasmodium falciparum, P. vivax, and Mixed-Species Malaria Antigens

Development and Evaluation of a Rapid Diagnostic Test for Plasmodium falciparum, P. vivax, and Mixed-Species Malaria Antigens

Mummies

Paléoparasitologie et immunologie. L’exemple d’Entamoeba histolytica

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