Diagnosis of Peritoneal Dissemination: Comparison of <sup>18</sup>F-FDG PET/CT, Diffusion-Weighted MRI, and Contrast-Enhanced MDCT

Satoh, Yoko; Ichikawa, Tomoaki; Motosugi, Utarou; Kimura, Kazufumi; Sou, Hironobu; Sano, Katsuhiro; Araki, Tsutomu

doi:10.2214/ajr.10.4687

Cited by 109 publications

(75 citation statements)

References 25 publications

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“…However, FDG-PET has given false-negative results for well-differentiated pulmonary adenocarcinoma (Higashi et al, 1998;Cheran et al, 2004), or small volumes of metabolically active tumor (Satoh et al, 2011), and false-positive results for inflammatory nodules (Goo et al, 2000;Nomori et al, 2004). In addition, FDG-PET is not widely available because of its high cost.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Usuda

Sagawa

Motono

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Usuda

Sagawa

Motono

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Thus, combined morphologic and metabolic assessment provided by PET/CT yields superior diagnostic results compared to morphologic assessment by contrast-enhanced CT. The combination with other functional imaging modalities including diffusion and perfusion MR imaging as provided by PET/ MRI might result in further improvement of the diagnostic performance in the follow-up after HIPEC [14,16]. The combination of PET and dynamic contrast-enhanced MRI might contribute besides metabolic information also information regarding tissue perfusion which might be useful in the differentiation between malignant and inflammatory tissue [11].…”

Section: Discussionmentioning

confidence: 99%

“…The combination of PET and dynamic contrast-enhanced MRI might contribute besides metabolic information also information regarding tissue perfusion which might be useful in the differentiation between malignant and inflammatory tissue [11]. Diffusion-weighted magnetic resonance imaging could further enhance tissue characterization in patients with recurrent PC after HIPEC [16]. These options may contribute to further improvement in the follow-up period of patients with PC after HIPEC using PET/MRI to assess recurrent PC.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Relapse in Patients with Peritoneal Carcinomatosis after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy using F-18-FDG-PET/CT

Klumpp

Schwenzer

Gatidis

et al. 2014

Fortschr Röntgenstr

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Purpose: In patients with peritoneal carcinomatosis (PC), cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is an evolving therapeutic approach with curative intention. The differentiation between posttherapeutic findings after HIPEC and relapse of PC is challenging. We evaluated the diagnostic value of F-18-FDG-PET/CT in patients with relapse of PC after HIPEC. Materials and Methods: 36 patients with recurring PC after HIPEC were examined on a whole-body PET/CT system (44 examinations). The examination included 3?D F-18-FDG-PET and contrast-enhanced CT. Images were assessed by two experienced readers regarding the presence and the extent of PC using the peritoneal carcinomatosis index (PCI). Imaging results were correlated with surgical findings or follow-up. Results: Relapse was suspected in 40 of 44 examinations. Relapse was missed by F-18-FDG PET/CT in 4 patients and significantly underestimated in 8 patients. The diagnostic accuracy for the detection of PC on a patient basis was 91?%, the sensitivity was 91?% and the positive predictive value was 100?%. The mean PCI was 11.4???11.9 for PET/CT, 8.4???10.3 for CT and 16.6???15.0 in the case of surgical exploration. The extent of PC was underestimated by PET/CT and even more by CT alone (p?

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“…Cui et al (80) concluded that the detection rate of extrahepatic cholangiocarcinoma was significantly higher for DWI (94.3%) than for MRCP (74.3%), and the positive and negative predictive values of DWI (100%, 91.3%) were higher than those of MRCP (81.3%, 62.5%). Additionally, DWI was found to be a useful technique for screening peritoneal dissemination in a cohort of 107 patients with primary gastrointestinal or genitourinary tract malignancies (81).…”

Section: Abdominal Applicationsmentioning

confidence: 99%

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

Türkbey

Aras

Karabulut

et al. 2011

Diagn Interv Radiol

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Imaging is used to detect, characterize, and monitor cancer. Recently, diffusion-weighted magnetic resonance imaging (DWI) has become a useful adjunct for assessing tumors with magnetic resonance imaging (MRI). DWI involves the acquisition of a magnetic resonance signal related to random thermal motion (Brownian motion) or the "diffusion" of water protons in tissue. The signal obtained with DWI is a measure of the net displacement of water molecules, e.g., the water path length in the extracellular, intracellular and intravascular spaces. This motion is largely random and can be reduced by structural barriers, such as cell membranes and collagen. Restricted diffusion in biological tissues is inversely proportional to tissue cellularity and the integrity of cell membranes, and it can be quantified with apparent diffusion coefficient (ADC) measurements (1). Depending on the microarchitecture, either restricted or increased diffusion can occur in malignant tumors. For instance, diffusion is restricted in cellular portions of the tumor, but it may be increased in necrotic portions (2, 3). Other causes of enhanced diffusion include increased water content arising from intratumoral edema and cystic tumor components (4-6).Although initially used to evaluate neurological diseases, the applications of DWI have been extended to oncologic imaging throughout the body made possible by improvements in MRI hardware and new sequences. The use of DWI as a complement to conventional MRI methods has led to improvements in the detection and characterization of tumors, treatment response monitoring, and detection of recurrence in oncology patients. Basic concepts of DWIIn 1965, Stejskal and Tanner (7) proposed the application of a symmetric pair of additional gradients on either side of the 180˚ refocusing radiofrequency pulse. The Stejskal-Tanner sequence is still the basis of modern DWI. For static water molecules, the phasing effect caused by the first gradient will be reversed by the second gradient, leading to no signal loss; however, this phasing effect will not be completely reversed if the water molecules are not stationary, which results in the observed well-known diffusion signal decay. The amount of diffusion weighting is determined by the b value, which describes the amplitude, duration of the applied gradient, and time interval between the two diffusion gradients (4). The degree of signal attenuation from water molecules is cor- ABSTRACT Diffusion-weighted magnetic resonance imaging (MRI), which involves the acquisition of a magnetic resonance signal related to the Brownian motion of water protons in tissue, has become a useful technique for assessing tumors. In this article, we review the basic concepts, imaging strategies, and body applications of diffusion-weighted MRI in detecting and monitoring cancer.

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Diagnosis of Peritoneal Dissemination: Comparison of ¹⁸F-FDG PET/CT, Diffusion-Weighted MRI, and Contrast-Enhanced MDCT

Abstract: PET/CT is the most useful technique for pathologic staging in the care of patients with malignant disease. If PET/CT is not available, DWI can be used as a screening tool.

Cited by 109 publications

References 25 publications

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Assessment of Relapse in Patients with Peritoneal Carcinomatosis after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy using F-18-FDG-PET/CT

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

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Diagnosis of Peritoneal Dissemination: Comparison of 18F-FDG PET/CT, Diffusion-Weighted MRI, and Contrast-Enhanced MDCT

Abstract: PET/CT is the most useful technique for pathologic staging in the care of patients with malignant disease. If PET/CT is not available, DWI can be used as a screening tool.

Cited by 109 publications

References 25 publications

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Diagnostic Performance of Diffusion Weighted Imaging of Malignant and Benign Pulmonary Nodules and Masses: Comparison with Positron Emission Tomography

Assessment of Relapse in Patients with Peritoneal Carcinomatosis after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy using F-18-FDG-PET/CT

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

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Diagnosis of Peritoneal Dissemination: Comparison of ¹⁸F-FDG PET/CT, Diffusion-Weighted MRI, and Contrast-Enhanced MDCT