Diagnosis of non-coeliac gluten sensitivity: First double blind placebo controlled cross over trial in pediatrics

Serologic Evaluation of Celiac Disease for Patients Younger Than 2 Years of Age

“…Also, histopathologic findings of duodenal biopsies consistent with celiac disease are seen in other common and uncommon pediatric intestinal diseases, such as Crohn's disease, viral gastroenteritis, autoimmune enteropathy, and food protein-induced enteropathy, [9][10][11] and although symptomatic response to gluten-free diet is a defining characteristic of celiac disease, it is subjective and nonspecific. 12,13 Serologic evidence of celiac autoimmunity is a crucial piece of the diagnostic puzzle for most patients. Serologic testing has evolved, and currently the recommended initial screening test for celiac disease in children and adults is tissue transglutaminase (TTG) immunoglobulin A (IgA).…”