Diagnosis of Neonatal Jaundice by Patterns of Serum Transaminase

Bile Acid Excretion and Malabsorption in Intrahepatic Cholestasis of Infancy (“Neonatal Hepatitis”)

“…The serum concentration of total and direct reacting bilirubin, and the serum activities of glutamic-oxalacetic and glutamic-pyruvate transaminases (GOT and GPT) (38) The serum activities of alkaline phosphatases, leucine aminope?tidase (LAP), and y-glutamyltranspeptidase (GT) are given in Table 2. In case A. W. alkaline phosphatases activity was normal €or a long period of clinical cholestasis.…”

Differential Diagnosis of Regurgitation Jaundice in Early Infancy*

“…In contradistinction the rise in enzyme activity in patients with congenital extrahepatic atresia was not initiated until later in the neonatal period at approximately 1-11,'L months of age. 20 Morris M. Cherniak, in our laboratories, has done a considerable amount of carefully controlled work to evaluate the use of this test in our material. The spectrophotometric method of Karman was used for the measurements.20 A total of 26 patients was studied, of whom 11 were proven by other means to be suffering from congenital biliary atresia, and 15 fell into the group of intrahepatic obstructive jaundice, the majority of these with giant cell hepatitis.…”