Diagnosis of Human Echinococcosis via Exhaled Breath Analysis: A Promise for Rapid Diagnosis of Infectious Diseases Caused by Helminths

Welearegay, Tesfalem Geremariam; Diouani, Mohamed Fethi; Österlund, Lars; Borys, Sebastian; Khaled, S.; Smadhi, H.; Ionescu, Florina; Bouchekoua, M.; Aloui, Dorsaf; Laouini, Dhafer; Cindemir, Umut; Ionescu, Radu

doi:10.1093/infdis/jiy449

Cited by 10 publications

(7 citation statements)

References 45 publications

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“…The dynamic sensors' operation mode employed in this study, implemented by applying short voltage pulses to the sensors (10 s duration) followed by longer inactivity periods (90 s duration), allowed for analyzing the surface adsorption-desorption reaction kinetics that occur between the sensing material and the sensed VOCs. This operation mode provides more information than the static operation mode when the sensor is continuously operated at a constant voltage [32].…”

Section: Discussionmentioning

confidence: 99%

Non-Invasive Method to Detect Infection with Mycobacterium tuberculosis Complex in Wild Boar by Measurement of Volatile Organic Compounds Obtained from Feces with an Electronic Nose System

Beleño-Sáenz

Cáceres-Tarazona

Nol

et al. 2021

Sensors

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More effective methods to detect bovine tuberculosis, caused by Mycobacterium bovis, in wildlife, is of paramount importance for preventing disease spread to other wild animals, livestock, and human beings. In this study, we analyzed the volatile organic compounds emitted by fecal samples collected from free-ranging wild boar captured in Doñana National Park, Spain, with an electronic nose system based on organically-functionalized gold nanoparticles. The animals were separated by the age group for performing the analysis. Adult (>24 months) and sub-adult (12–24 months) animals were anesthetized before sample collection, whereas the juvenile (<12 months) animals were manually restrained while collecting the sample. Good accuracy was obtained for the adult and sub-adult classification models: 100% during the training phase and 88.9% during the testing phase for the adult animals, and 100% during both the training and testing phase for the sub-adult animals, respectively. The results obtained could be important for the further development of a non-invasive and less expensive detection method of bovine tuberculosis in wildlife populations.

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Section: Discussionmentioning

confidence: 99%

Non-Invasive Method to Detect Infection with Mycobacterium tuberculosis Complex in Wild Boar by Measurement of Volatile Organic Compounds Obtained from Feces with an Electronic Nose System

Beleño-Sáenz

Cáceres-Tarazona

Nol

et al. 2021

Sensors

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“…When sensors responses were individually analyzed for each sensor, the best discrimination accuracy was obtained by sensor S3. Alkane derivatives, such as methane, propane and iso-butane, detected by sensor S3, are recurrent oxidation products in the process of lipid peroxidation caused by highly unstable reactive oxygen species produced by the host as a result of immune responses against echinococcus infection [15,26,27]. Ethanol (detected by sensors S3 and S1) and ammonia (detected by sensors S3 and S2) are common breath metabolites.…”

Section: Sensors Characteristicsmentioning

confidence: 99%

“…In a very recent study, it was shown that a specifically-designed electronic nose system based on organically-functionalized metal nanoparticles trained for the detection of AE pattern in exhaled breath can discriminate with high accuracy between AE patients and healthy controls [15]. In that study, the sensors were operated in the DC mode.…”

Section: Introductionmentioning

confidence: 99%

“…In that study, the sensors were operated in the DC mode. In the present study, we assess the performance of both DC and AC sensing methods for the diagnosis of AE from exhaled breath analysis, on a patient cohort completely independent of the one reported in [15]. For performing this study, we selected an array of Taguchi type chemical gas sensors that present a priori important features associated with AE metabolism compounds, and a novel custom gas sensor based on WO 3 nanowires doped with gold nanoparticles that was recently reported for breath sensing and can further favor breath VOCs detection [16].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Electronic Sensing Techniques for the Rapid Identification of Alveolar Echinococcosis through Exhaled Breath Analysis

Kwiatkowski

Chludziński

Saidi

et al. 2020

Sensors

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Here we present a proof-of-concept study showing the potential of a chemical gas sensors system to identify the patients with alveolar echinococcosis disease through exhaled breath analysis. The sensors system employed comprised an array of three commercial gas sensors and a custom gas sensor based on WO3 nanowires doped with gold nanoparticles, optimized for the measurement of common breath volatile organic compounds. The measurement setup was designed for the concomitant measurement of both sensors DC resistance and AC fluctuations during breath samples exposure. Discriminant Function Analysis classification models were built with features extracted from sensors responses, and the discrimination of alveolar echinococcosis was estimated through bootstrap validation. The commercial sensor that detects gases such as alkane derivatives and ethanol, associated with lipid peroxidation and intestinal gut flora, provided the best classification (63.4% success rate, 66.3% sensitivity and 54.6% specificity) when sensors’ responses were individually analyzed, while the model built with the AC features extracted from the responses of the cross-reactive sensors array yielded 90.2% classification success rate, 93.6% sensitivity and 79.4% specificity. This result paves the way for the development of a noninvasive, easy to use, fast and inexpensive diagnostic test for alveolar echinococcosis diagnosis at an early stage, when curative treatment can be applied to the patients.

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“…As a new odor scanner developed in recent years, electronic nose had been widely used in medicine, food, beverage, cosmetics, and other fields. Welearegay et al [7] used electronic nose to diagnose the helminth infectious diseases based on the patience's exhalations. Li et al [8] used this technology to distinguish the Kiwifruit from different origins in China.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Volatile Components of Auricularia auricula from Different Origins by GC-MS Combined with Electronic Nose

Yang

Liu

et al. 2020

Journal of Food Quality

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Auricularia auricula is a kind of nutrient-rich edible fungus, which has the reputation of “king of vegetarians.” In this paper, the electronic nose combined with GC-MS technology was used to analyze the volatile components of A. auricula in Heilongjiang, Jilin, Shanghai, and Sichuan provinces to investigate the differences and characteristics of A. auricula in different origins. The results showed that the electronic nose could obviously distinguish the samples from Jilin and Shanghai with a high degree of discrimination, while it was inappropriate to distinguish the samples from Heilongjiang and Sichuan Province. GC-MS was used to further analyze the volatile compounds in A. auricula qualitatively and quantitatively. The results showed that 98 volatile components were detected and 23 of them were common components, including alcohols, aldehydes, acids, esters, hydrocarbons, and other volatile components. The relative content of acetic acid and diethyl azodicarboxylate in A. auricula from the four origins was relatively high. According to the relative odor activity value (ROAV), it was found that the key compounds that caused the aroma difference between different origins were 1-octene-3-ol, cis-3-nonene-1-ol, (E)-2-octenal, (E)-2-nonenal, (E,E)-2,4-nonadienal, and 3-methyl butanal.

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Diagnosis of Human Echinococcosis via Exhaled Breath Analysis: A Promise for Rapid Diagnosis of Infectious Diseases Caused by Helminths

Abstract: Here we advocate a non-invasive, fast, easy-to-operate and non-expensive diagnostic tool for the diagnosis of human echinococcosis disease through exhaled breath analysis, suitable for early diagnosis and population screening.

Cited by 10 publications

References 45 publications

Non-Invasive Method to Detect Infection with Mycobacterium tuberculosis Complex in Wild Boar by Measurement of Volatile Organic Compounds Obtained from Feces with an Electronic Nose System

Non-Invasive Method to Detect Infection with Mycobacterium tuberculosis Complex in Wild Boar by Measurement of Volatile Organic Compounds Obtained from Feces with an Electronic Nose System

Assessment of Electronic Sensing Techniques for the Rapid Identification of Alveolar Echinococcosis through Exhaled Breath Analysis

Analysis of Volatile Components of Auricularia auricula from Different Origins by GC-MS Combined with Electronic Nose

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