Diagnosis of Helicobacter pylori infection in clinical practice

Bordin, D.S.; Voynovan, Irina; Kolbasnikov, S.V.; Embutnieks, Yu.V.

doi:10.26442/00403660.2018.12.000020

Cited by 16 publications

(8 citation statements)

References 24 publications

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“…Infections are thought to occur early in life (during childhood) and the infection implicates several medical conditions including chronic gastritis, gastric cancer, gastric adenocarcinoma, mucosa-associated lymphoid tissue (MALT), lymphoma, and peptic ulcer disease [ 2 – 5 ]. Infected individuals present with gastric reflux, abdominal pain, intestinal bleeding, occasional fevers, and loss of weight which if not treated can result in gastric ulceration and perforation [ 6 ]. The incidence and prevalence rates of childhood infection with H .…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors ofHelicobacter pyloriInfection among Children Aged 1 to 15 Years at Holy Innocents Children’s Hospital, Mbarara, South Western Uganda

Aitila

Mutyaba

Okeny

et al. 2019

Journal of Tropical Medicine

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Background.Helicobacter pyloriinfection affects more than half of the world’s population. The infection is generally acquired during childhood but can remain asymptomatic, with long-term clinical sequelae including gastritis, peptic ulcer disease, and stomach cancer.Methods. The study was approved by Institutional Review Committee of Mbarara University of Science and Technology. After obtaining informed consent from parents/legal guardians, illegible children who presented with gastrointestinal complaints at Holy Innocents Children’s Hospital were recruited; structured questionnaires were administered to the parents/guardians to collect information on sociodemographic data and risk factors ofH. pyloriinfection. Four (4) millilitres of blood was collected from each child and tested forH.pyloriblood Antibody test and stool specimens were used forH. pyloriantigen test.Results. The prevalence ofH. pyloriinfection among the study participants was 24.3%. The infection rate increased with increase in age of the participants, from 16.2% among 1to 5 years old to 27.2% among 6 to 10 years. Infections were higher among school going children (68/74, p=0.003, OR 3.9; CI: 1.5 to 10.6) and children from crowded households (59/74, p<0.001, OR 2.6, and CI 1.3 to 5.0), unsafe source of drinking water at schools (46/74, p=0.003), and lack of sanitary facility at homes (57/74, p=0.001, and OR 1.6 CI 0.7 to 3.6).Conclusion. The prevalence ofH. pyloriinfection among children aged 1 to 15 years at Holy Innocents Children’s Hospital was high and increases with age. School attendance, lack of sanitary facility, lack of safe drinking water, and overcrowding were the risk factors associated withH. pyloriinfection.

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Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors ofHelicobacter pyloriInfection among Children Aged 1 to 15 Years at Holy Innocents Children’s Hospital, Mbarara, South Western Uganda

Aitila

Mutyaba

Okeny

et al. 2019

Journal of Tropical Medicine

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“…в 26,2% случаев. В тот же период времени в Москве назначения БУТ и цитологического/гистологического исследований для оценки эффективности эрадикации встречались только в 1,2 и 0,8% случаях соответственно [19].…”

Section: ðèñ 4 ñõåìû ýðàäèêàöèîííîé òåðàïèè íàçíà÷åííûå â êà÷åñòâåunclassified

European Registry on the management of Helicobacter pylori infection: features of diagnosis and treatment in Kazan

Абдулхаков

Bordin

Абдулхаков³

et al. 2020

Terapevticheskii arkhiv

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Background. As part of an observational multicenter prospective study European Registry on the management of Helicobacter pylori infection, conducted on the initiative of the European H. pylori and Microbiota Study Group, the compliance of clinical practice in the management of patients with Helicobacter pylori infection in Kazan with clinical guidelines was assessed. Materials and methods. The data of 437 patients included into the register by clinical sites in Kazan in 20132019 were analyzed. The methods used for the initial diagnosis of H. pylori infection and eradication control were evaluated. The frequency of various eradication therapy regimens prescription was analyzed in 379 cases. Data regarding the effectiveness of eradication therapy was analyzed in 173 patients. Results. The rapid urease test (44.2% of cases) and cytology/histology (60% of cases) were most often used for the initial diagnosis of H. pylori infection; however non-invasive methods such as 13C-urea breath (9.2%), serology (6.2%), H. pylori stool antigen test (2.3%) were less common. In 21.7% of patients two methods of H. pylori detection were used for primary diagnosis. The control test to evaluate the effectiveness of eradication therapy at the recommended timepoint was performed in 46.2% of patients. 13C-urea breath test (31.7%), stool PCR/stool antigen test (28.7%), rapid urease test (22.3%), cytology/histology (26.2% of cases) prevailed in the assessment of eradication rate. Standard triple therapy, including proton pump inhibitor, clarithromycin and amoxicillin was most commonly prescribed as first-line therapy (64.6% of cases). The duration of eradication therapy was 14 days in the majority of cases with pantoprazole as the most common proton pump inhibitor in standard triple therapy regimens (84.8%). The efficacy of 14-day standard triple therapy (mITT) was 87.0%. Conclusion. The results indicate a high frequency of non-invasive methods use for assessing the effectiveness of eradication therapy; however, the overall rate of eradication efficacy assessment is low, limiting the possibility of analyzing the eradication results. The effectiveness of the most common 14-day standard triple first-line therapy in Kazan doesnt reach the recommended 90% eradication level. This could be explained by high rate of pantoprazole use, which is not an optimal proton pump inhibitor in eradication therapy regimens.

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“…БУТ допускается для первичной диагностики, но при этом не рекомендуется для исключения наличия инфекции и для оценки эрадикации из-за его недостаточной чувствительности. Серологический тест (определение IgG-антител к H. pylori в крови) можно использовать только у ранее не леченных пациентов, у которых положительный результат позволяет назначить лечение, однако для контроля эрадикации данный тест не может применяться, так как он отражает факт наличия инфекции в прошлом, но не в настоящее время [20]. Следует отметить, что это довольно частая ошибка в реальной клинической практике.…”

Section: îáñóAeäåíèåunclassified

European registry on Helicobacter pylori management (Hp-EuReg) as a tool to evaluate and improve clinical practice in Moscow

Bordin

Voynovan

Embutnieks

et al. 2020

Terapevticheskii arkhiv

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Continuous evaluation of the actual clinical practice of diagnosis and treatment of Helicobacter pylori is crucial in order to provide the best standard of care and to compare health outcomes with expert recommendations. Aim:to evaluate the effectiveness of the standard triple therapy (amoxicillin, clarithromycin, a proton pump inhibitor) and the standard triple therapy plus bismuth tripotassium dicitrate. Materials and methods.Observational, prospective, multicenter study, carried out in one single Russian centre A.S. Loginov Moscow Clinical Scientific Center as part of the Hp-EuReg. Patients were included from 2013 to November 2019 by Russian gastroenterologists. Results.A total of 647 patients were collected and 330 were administered either standard triple therapy ((amoxicillin, clarithromycin, a proton pump inhibitor) or standard triple therapy plus bismuth tripotassium dicitrate. Invasive methods is dominates in the initial diagnosis of H. pylori: the frequency of use of the quick urease test decreased from 50% in 2013 to 31% in 2019. Serology was used in 27.9%. There has been an increase in the use of the13C-urea breath test from 13% in 2013 to 31% in 2019. The histological method (7.5%) and the stool antigen test (3.2%) were used less frequently. For eradication control non-invasive methods are mostly used:13C-UDT (82.7%) and the stool antigen test (14.4%). The effectiveness of standard triple therapy (mITT) was 68% with a 7-day course, 79% with a 10-day course, and 70% with a 14-day course. Combination of bismuth and standard triple therapy eradicates H. pylori (mITT) in 63%, 75% and 89%, respectively. Conclusion.An improvement in the clinical practice of managing patients with H. pylori infections has been noted. The standard triple therapy in combination with bismuth tripotassium dicitrate, prescribed for 14 days, is more effective.

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Diagnosis of Helicobacter pylori infection in clinical practice

Cited by 16 publications

References 24 publications

Prevalence and Risk Factors ofHelicobacter pyloriInfection among Children Aged 1 to 15 Years at Holy Innocents Children’s Hospital, Mbarara, South Western Uganda

Prevalence and Risk Factors ofHelicobacter pyloriInfection among Children Aged 1 to 15 Years at Holy Innocents Children’s Hospital, Mbarara, South Western Uganda

European Registry on the management of Helicobacter pylori infection: features of diagnosis and treatment in Kazan

European registry on Helicobacter pylori management (Hp-EuReg) as a tool to evaluate and improve clinical practice in Moscow

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