Diagnosis of Delayed Cerebral Radiation Necrosis Following Proton Beam Therapy

Radiation Necrosis Following Proton Beam Therapy in the Pediatric Population: a Case Series

“…Since their report, multiple case series and studies have shown this finding in a wide variety of neoplastic lesions, utilizing distinct radiation treatment protocols. Several of these available reports consist of patients who received proton beam radiation therapy [ 1 , 3 , 5 ].…”

“…Clearly, Grade 1 and Grade 2 lesions can be subtle, with potentially misleading findings on post-operative MRI imaging. Other studies have noted that the most common findings in radiation necrosis in pediatric patients were multiple small areas of enhancement distant from the site of surgical resection [ 3 , 5 ].…”

Radiation Necrosis Following Proton Beam Therapy in the Pediatric Population: a Case Series

“…Since their report, multiple case series and studies have shown this finding in a wide variety of neoplastic lesions, utilizing distinct radiation treatment protocols. Several of these available reports consist of patients who received proton beam radiation therapy [ 1 , 3 , 5 ].…”

“…Clearly, Grade 1 and Grade 2 lesions can be subtle, with potentially misleading findings on post-operative MRI imaging. Other studies have noted that the most common findings in radiation necrosis in pediatric patients were multiple small areas of enhancement distant from the site of surgical resection [ 3 , 5 ].…”

Three discipline collaborative radiation therapy (3DCRT) special debate: The United States needs at least one carbon ion facility

“…Several papers have identified this as a potential problem in proton therapy, specifically more brain necrosis than expected. This may be due to the RBE in normal brain for protons being higher than 1.1, which is likely only more probable if using carbon ions and a SOBP.…”

Radiation Necrosis Following Proton Beam Therapy in the Pediatric Population: a Case Series

“…Since their report, multiple case series and studies have shown this finding in a wide variety of neoplastic lesions, utilizing distinct radiation treatment protocols. Several of these available reports consist of patients who received proton beam radiation therapy [ 1 , 3 , 5 ].…”

“…Clearly, Grade 1 and Grade 2 lesions can be subtle, with potentially misleading findings on post-operative MRI imaging. Other studies have noted that the most common findings in radiation necrosis in pediatric patients were multiple small areas of enhancement distant from the site of surgical resection [ 3 , 5 ].…”

Three discipline collaborative radiation therapy (3DCRT) special debate: The United States needs at least one carbon ion facility

“…Several papers have identified this as a potential problem in proton therapy, specifically more brain necrosis than expected. This may be due to the RBE in normal brain for protons being higher than 1.1, which is likely only more probable if using carbon ions and a SOBP.…”

Radiation Necrosis Following Proton Beam Therapy in the Pediatric Population: a Case Series

“…Since their report, multiple case series and studies have shown this finding in a wide variety of neoplastic lesions, utilizing distinct radiation treatment protocols. Several of these available reports consist of patients who received proton beam radiation therapy [ 1 , 3 , 5 ].…”

“…Clearly, Grade 1 and Grade 2 lesions can be subtle, with potentially misleading findings on post-operative MRI imaging. Other studies have noted that the most common findings in radiation necrosis in pediatric patients were multiple small areas of enhancement distant from the site of surgical resection [ 3 , 5 ].…”

Three discipline collaborative radiation therapy (3DCRT) special debate: The United States needs at least one carbon ion facility

“…Several papers have identified this as a potential problem in proton therapy, specifically more brain necrosis than expected. This may be due to the RBE in normal brain for protons being higher than 1.1, which is likely only more probable if using carbon ions and a SOBP.…”