Diagnosis of celiac disease on a gluten-free diet: a multicenter prospective quasi-experimental clinical study
Sara Gómez-Aguililla,
Sergio Farrais,
Natalia López-Palacios
et al.
Abstract:BackgroundDiagnosing celiac disease (CD) in individuals adhering to a gluten-free diet (GFD) presents significant challenges. Current guidelines recommend a gluten challenge (GC) lasting at least 6-8 weeks, which has several limitations.ObjectivesThis study compares four approaches previously proposed for diagnosing CD on a GFD: IL-2 serum levels, gut-homing CD8+T cells, %TCRγδ+intraepithelial lymphocytes (IELs), andUBE2L3gene expression. Additionally, we evaluated the CD8+T-cell based method with a 3-day GC a… Show more
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