Diagnosis and treatment of the neutrophilic dermatoses (pyoderma gangrenosum, Sweet's syndrome)

Dabade, Tushar S.; Davis, Mark D.P.

doi:10.1111/j.1529-8019.2011.01403.x

Cited by 53 publications

(42 citation statements)

References 77 publications

(92 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to the two major criteria (abrupt onset of tender or painful erythematous or violaceous plaques or nodules and neutrophilic infiltration of the dermis without leukocytoclastic vasculitis), he had three minor criteria (elevation of the CRP level, leukocytosis and preceding slight fever) [2]. Like our case report, cases of SS with recurrent oral ulcerations were reported [1,[4][5][6][7].…”

Section: Discussionsupporting

confidence: 64%

“…Neutrophilic dermatoses, including Sweet's syndrome (SS), pyoderma gangrenosum (PG), subcorneal pustular dermatosis (Sneddon-Wilkinson disease (SW)) and rheumatoid neutrophilic dermatitis, are inflammatory conditions of the skin often associated with underlying systemic disease [2]. Some deserve great attention due to major symptoms and the concept of reactive disease or for being a marker for other pathologies, especially neoplastic diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sweet’s syndrome revealed by oral pustulosis

Fricain

Sibaud

Lepreux

et al. 2015

Med Buccale Chir Buccale

View full text Add to dashboard Cite

-Introduction:Neutrophilic dermatoses are conditions characterized by a dermal neutrophilic infiltration associated with variable leukocytoclasia. Oral involvement occurs but is rare and is of less importance than the cutaneous involvement. Observation: The case of a 71-year-old man with neutrophilic dermatoses in whom the major manifestations of the disease were recurrent oral ulcers associated with tongue pustulosis is reported. Oral and skin biopsies revealed a dense neutrophilic infiltrate in the lamina propria. Clinical symptoms were quickly resolved with colchicine treatment. The clinical course allowed us to diagnose Sweet's syndrome associated with oral pustulosis. Discussion: The main differential diagnosis of Sweet's syndrome is from Behçet's disease. Overlap exists between the manifestations of the two diseases, so they must be differentiated. The recurrence of oral ulcers with little inflammatory halo and the quick resolution of ulcers associated with pustules, as well as the histological patterns, were not compatible with Behçet's disease. Résumé -Introduction :Les dermatoses neutrophiles sont caractérisées par une infiltration neutrophilique cutanée associée à une leucocytoclasie. Les manifestations orales sont rares et moins bruyantes qu'au niveau de la peau. Observation : Le cas d'un homme de 71 ans avec une dermatose neutrophile dont les principales manifestations de la maladie étaient des ulcères buccaux récurrents associés à une pustulose linguale est rapporté. Les biopsies buccales et cutanées ont révélé un infiltrat neutrophilique dense dans la lamina propria. Les symptômes cliniques ont été rapidement résolus avec de la colchicine. L'évolution clinique a permis de diagnostiquer un syndrome de Sweet associé à une pustulose orale. Discussion : Le principal diagnostic différentiel du syndrome de Sweet est la maladie de Behçet. Des chevauchements existent entre les manifestations cliniques des 2 entités. Mais celles-ci n'ont pas le même pronostic et doivent être différenciées. La récurrence des ulcères buccaux avec un discret halo inflammatoire, la résolution rapide des ulcères associés aux pustules ainsi que les aspects histologiques du cas décrit, n'étaient pas compatibles avec la maladie de Behçet.

show abstract

Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Sweet’s syndrome revealed by oral pustulosis

Fricain

Sibaud

Lepreux

et al. 2015

Med Buccale Chir Buccale

View full text Add to dashboard Cite

show abstract

“…Muchas veces estas patologías se relacionan con una respuesta inmune inadecuada la cual puede desencadenar PG. Su resolución puede conducir también a la cura de PG, aunque algunas veces esta se comporta en forma independiente a la enfermedad asociada 19 . En el tratamiento sistémico, uno de los esteroides más usados es la prednisona en dosis de 1-2 mg/ Kg/dia, debido a su rápida respuesta (2-3 días) 1 .…”

Section: Discussionunclassified

Pioderma gangrenoso en mamoplastía de reducción con pedículo inferior

et al. 2013

Rev Chil Cir

View full text Add to dashboard Cite

Pyoderma gangrenosum secondary to reduction mammoplasty Background: Pyoderma gangrenosum (PG) is an uncommon inflammatory and ulcerative disorder of the skin. It may be associated with immune deficiencies. It is usually located in the extremities and its appearance after reduction mammoplasty is exceptional. We report three patients with the disease. A 54 years old female subjected to a bilateral reduction mammoplasty with an inferior pedicle. She developed a pyoderma gangrenosum and was treated with systemic steroids and local application of Dapsone with remission of lesions and healing after one month of evolution. A 23 years old women subjected to the same surgical procedure, which developed a wound dehiscence with ulcerative lesions, was treated with steroids and Azathioprine, reducing the local inflammation but leaving a severe esthetic sequel. A 21 years old woman subjected to the same surgical procedure, develop bilateral wound dehiscence and ulcerative lesions, she was treated with steroids and antimicrobials achieving a secondary healing.

show abstract

“…16 Although no randomized controlled trials have been performed, systemic corticosteroids have been the mainstay of treatment and typically, a rapid response is observed within days to weeks. In combination with steroids or in resistant cases, other immunosuppressant agents may be used, such as cyclosporine A, azathioprine, methotrexate, or mycofenolatemofetil.…”

Section: Treatmentmentioning

confidence: 99%