Diagnosis and treatment of an acute severe pneumonia patient with COVID‐19: Case report

Deng, Zhe; Hu, Ya-Han; Yang, Ping; Zheng, Piao; Peng, Wenfeng; Ren, Baizhao; Zeng, Xiangbo; Tian, Xuefei

doi:10.1002/jmv.25802

Cited by 12 publications

(13 citation statements)

References 1 publication

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“…Interestingly some of the data suggest that NPS tests may occasionally be negative when the corresponding saliva test gives a positive result. Azzi et al reported that two patients showed positive saliva tests while their NPS tests were negative ( 14 ), and a case report showed that in seven sample pairs from one individual, the NPS tests were all negative while the saliva tests were positive on each occasion ( 19 ). In a sample-based study of 38 patients, Wyllie et al ( 21 ) detected SARS-CoV-2 in saliva but not NPS specimens from eight patients (21%), while the virus was detected in NPS but not saliva in only 3 matched samples (8%).…”

Section: Resultsmentioning

confidence: 99%

Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis

et al. 2020

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Background: COVID-19 is a serious and potentially deadly disease. Early diagnosis of infected individuals will play an important role in stopping its further escalation. The present gold standard for sampling is the nasopharyngeal swab method. However, several recent papers suggested that saliva-based testing is a promising alternative that could simplify and accelerate COVID-19 diagnosis. Objectives: Our aim was to conduct a meta-analysis on the reliability and consistency of SARS-CoV-2 viral RNA detection in saliva specimens. Methods: We have reported our meta-analysis according to the Cochrane Handbook. We searched the Cochrane Library, Embase, Pubmed, Scopus, Web of Science and clinical trial registries for eligible studies published between 1 January and 25 April 2020. The number of positive tests and the total number of tests conducted were collected as raw data. The proportion of positive tests in the pooled data were calculated by score confidence-interval estimation with the Freeman–Tukey transformation. Heterogeneity was assessed using the I 2 measure and the χ 2 -test. Results: The systematic search revealed 96 records after removal of duplicates. Twenty-six records were included for qualitative analysis and 5 records for quantitative synthesis. We found 91% (CI 80–99%) sensitivity for saliva tests and 98% (CI 89–100%) sensitivity for nasopharyngeal swab (NPS) tests in previously confirmed COVID-19 patients, with moderate heterogeneity among the studies. Additionally, we identified 18 registered, ongoing clinical trials of saliva-based tests for detection of the virus. Conclusion: Saliva tests offer a promising alternative to NPS for COVID-19 diagnosis. However, further diagnostic accuracy studies are needed to improve their specificity and sensitivity.

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Section: Resultsmentioning

confidence: 99%

Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis

et al. 2020

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“…SARS-CoV-2 is the seventh and most novel human coronavirus. It emerged as a highly pathogenic species in December 2019 in Wuhan City, China and has since quickly spread to all continents except Antartica [5]. As of the time of this writing, the number of confirmed cases is more than one milion with thousands of deaths (https://www.…”

Section: Discussionmentioning

confidence: 99%

Comparing the analytical performance of three SARS-CoV-2 molecular diagnostic assays

Uhteg

Jarrett

Richards

et al. 2020

Journal of Clinical Virology

118

114

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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“…5,9 TCM was found to be effective when used along with Western medicine but cannot be used as a single modality for treatment. 4,16,17 Convalescent plasma therapy 8,19 , Intravenous…”

Section: Resultsmentioning

confidence: 99%

“…Amidst COVID-19 outbreak traditional Chinese medicine was used in conjunction with western medicines like antivirals, antibiotics, oxygen therapy, interferon, and methylprednisolone. 4,16,17 Patients receiving a combination of Chinese medicine and Western medicine showed significant improvement. In a clinical trial of 562 patients, both groups showed a lowering of fever but the group receiving a combination of Chinese and Western medicine showed a smoother decrease in body temperature to normal as compared to fluctuating fever in the group receiving only western medicine.…”

mentioning

confidence: 99%

Comparison of effectiveness of various treatment strategies in COVID-19 patients: A Systematic Review

Hussain¹,

Ali²,

Yousaf³

et al. 2020

JRMC

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Background: The purpose of this study is to systematically review the effectiveness of various drugs and therapies by assessing already conducted studies on COVID-19 patients. Methods: The eligibility criterion for this systematic review was to include the observational and experimental studies including case reports; conducted on the possible treatments of COVID-19. Only those studies were included that were written in the English language either published or unpublished from December 2019 to April 10, 2020. Quality of articles was assessed and flawed studies were excluded based on incomplete outcome data. Treatment strategies experimented on animals or those assessed through artificial intelligence were also excluded. The databases searched were PubMed, Google Scholar, Cochrane Library, and bioRxiv. The last date to search the databases was April 10, 2020. Results: We selected 25 articles which include 12 case studies, 10 retrospective studies, one randomized controlled trial, one non-randomized Controlled trial, and one prospective observational study. Hydroxychloroquine proved to be effective in all three studies under consideration especially when it was used in a combination with azithromycin. Antivirals showed significant results in eleven out of sixteen studies. The remaining five studies showed antiviral therapy to be ineffective. Lopinavir/ritonavir did not show satisfactory results in most of the COVID-19 patients. Both of the studies regarding convalescent plasma therapy showed significant improvement in patients undergoing treatment. Two studies regarding treatment with immunoglobulins also showed good results. A study on the use of Mesenchymal stem cell transplant for treatment of COVID-19 patients also proved to be effective. Likewise, a study on the use of Traditional Chinese Medicine along with Western Medicine also showed good results. In patients of organ transplant, withdrawal of immunosuppressive drugs, and the use of methylprednisolone along with antivirals had shown significantly good results. Among all these therapeutic approaches we found convalescent plasma therapy to be most effective. Conclusion: So far, a small number of studies have been conducted on the treatment of COVID-19 patients and most of them were conducted on the Chinese population. More randomized controlled trials are needed to evaluate the effectiveness of different treatment strategies at a broader level.

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Diagnosis and treatment of an acute severe pneumonia patient with COVID‐19: Case report

Cited by 12 publications

References 1 publication

Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis

Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis

Comparing the analytical performance of three SARS-CoV-2 molecular diagnostic assays

Comparison of effectiveness of various treatment strategies in COVID-19 patients: A Systematic Review

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