Diagnosis and surgical treatment of duodenal tumors

Кригер, А Г; Gorin, D S; Panteleev, V I; Калдаров, А. Р.

doi:10.17116/hirurgia20190115

Cited by 4 publications

(3 citation statements)

References 27 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the duodenum is the 1st part of the small Original Article Surgical treatment and survival analysis of primary duodenal malignant tumor: a retrospective cohort study intestine, and tumor treatment is quite difficult due to its relationship with the hepatobiliary system and pancreas. There are several distinct subtypes of PDMT, including duodenal adenocarcinomas (DAs), which account for about 50-70% of PDMTs, duodenal gastrointestinal stromal tumors (d-GISTs), which account for nearly 30% of PDMTs, and neuroendocrine tumors, which account for 1-3% of PDMTs (3). There is no specific clinical presentation of PDMT at the early stage, which results in a low rate of diagnosis or misdiagnoses of other abdominal diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surgical treatment and survival analysis of primary duodenal malignant tumor: a retrospective cohort study

Zhao¹,

Zhang²,

Li³

et al. 2022

J Gastrointest Oncol

View full text Add to dashboard Cite

Background: A primary duodenal malignant tumor (PDMT) is an extremely uncommon malignancy that originates from a gastrointestinal tract tumor. Currently, there is no unified, effective surgical treatment for PDMTs. In this retrospective study, we sought to analyze and evaluate the surgical procedure for PDMTs including pancreaticoduodenectomy (PD) and limited resection (LR), expect to inform the management of PDMT.Methods: We retrospectively reviewed patients with PDMT who underwent PD and LR in General Surgery Department of Tianjin Medical University General Hospital from January 2014 to December 2019. The clinical characteristics of the malignant tumors among the different segment of the duodenum were analyzed. We analyzed and compared the efficacy and safety of these two surgical treatments. Through survival result of the patients, we analyzed the survival factors affecting the PDMT.Results: Of the 94 patients, 60 (63.8%) were diagnosed with duodenal adenocarcinomas (DAs), 32 (34.1%) with duodenal gastrointestinal stromal tumors (d-GISTs), and 2 (2.1%) with duodenal lymphomas.Of the duodenal malignancies localized in the descending (D2) segment, 72.6% were DAs, and the initial symptom was jaundice (27.4%). Comparing with D2, d-GISTs were more common in the non-D2 segment (50.0%), and 46.9% of these patients presented with anemia as a primary symptom. PDs (87.1%) were more commonly performed for malignancies localized in the D2 segment, and LRs (59.4%) were more commonly performed for malignancies localized in the non-D2 segment (P<0.05). Conclusions:In this study, we found that PDMT is more likely to occur in the D2 segment than the other segments, and the most common pathological type is DA. Treatment decisions for PD and LR might depend on the tumor type, location, and whether invasion of the pancreas. PD might be the first choice of treatment for PDMTs located in the D2 segment; otherwise, LR would be preferred. Further studies, preferably large randomized clinical trials, are needed to confirm these results.

show abstract

Section: Introductionmentioning

confidence: 99%

“…1, P value was calculated by Fisher's exact test;2 , P value was calculated by the Mann-Whitney U-test;3 , the data are normally distributed.D2, descending; GIST, gastrointestinal stromal tumor; PD, pancreaticoduodenectomy; LR, limited resection.…”

mentioning

confidence: 99%

Surgical treatment and survival analysis of primary duodenal malignant tumor: a retrospective cohort study

Zhao¹,

Zhang²,

Li³

et al. 2022

J Gastrointest Oncol

View full text Add to dashboard Cite

show abstract

“…Alteration in biomarker levels, such as serum chromogranin A and neuron-specific enolase, provides information on diagnosis and prognosis; upper endoscopy with biopsies and endoscopic ultrasound confirm diagnosis and degree of local spreading [ 6 ]. Current imaging modalities include both computed tomography (CT) and magnetic resonance imaging (MRI) [ 7 ]. Somatostatin receptor analogue scintigraphy in combination with CT (positron emission tomography [PET]-CT) is mandatory to detect small lymph nodes or liver/bone/extra-abdominal metastases [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Extended surgical resection for nonfunctioning duodenal neuroendocrine tumor

Lucandri

Fiori

Lucchese

et al. 2022

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Duodenal neuroendocrine tumors (NETs) account for <3% of all gastrointestinal NET. Most lesions are small-sized and are located in the first or second duodenal part. Tumoral grading, evaluated by Ki67 index, strongly influences patient’s outcome. Endoscopic resection is recommended for lesions measuring <2 cm, while pancreaticoduodenectomy should be the treatment of choice for large duodenal NET; Whipple procedure should be preferred in case of duodenal origin and contiguity with gastric antrum. Involvement of surrounding structures, as well as the presence of resectable liver metastases, does not contraindicate surgical resection. Herein we report a case of a 68-year-old male, presenting with an extensive mass of the descending pre-ampullary duodenal part, with involvement of the right colon and the presence of a pericholecystic single liver metastasis. In spite of such advanced disease, surgery on the patient was successful, with an uneventful postoperative outcome.

show abstract