Diagnosis and staging of small bowel tumours

Gore, Richard M.; Mehta, Uday K.; Berlin, Jonathan W.; Rao, Vikram A.; Newmark, Geraldine M.

doi:10.1102/1470-7330.2006.0031

Cited by 56 publications

(50 citation statements)

References 14 publications

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“…After contrast agent administration lymphoma demonstrates homogeneous, mild enhancement. Necrosis or fistulous tracts to the adjacent bowel loops have been described, mainly in the exophytic form [45], with increased risk of perforation during chemotherapy. Satellite lymphadenopaties are usually bulky (Figure 14), larger than in other neoplasms and may be used as a differential sign [14].…”

Section: Lymphomamentioning

confidence: 99%

Malignant tumours of the small intestine: a review of histopathology, multidetector CT and MRI aspects

Anzidei¹,

Napoli²,

Zini³

et al. 2011

BJR

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ABSTRACT. Small bowel neoplasms, including adenocarcinoma, carcinoid tumour, lymphoma and gastrointestinal stromal tumours, represent a small percentage of gastrointestinal cancers, yet are among those with the poorest prognosis compared with other gastrointestinal malignancies. Unclear clinical scenarios and difficult radiological diagnosis often delay treatment with negative effects on patient survival. Recently, multidetector CT (MDCT) and MRI have been introduced as feasible and accurate diagnostic techniques for the identification and staging of small bowel neoplasms. These techniques are gradually replacing conventional barium radiography as the tool of choice. However, the inherent technical and physiological challenges of small bowel imaging require a familiarity with patient preparation and scan protocols. Adequate knowledge of the histopathology and natural evolution of small bowel neoplasms is also important for differential diagnosis. The aim of this article is to review MDCT and MRI protocols for the evaluation of small bowel tumours and to provide a concise yet comprehensive guide to the most relevant imaging features relative to histopathology.

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Section: Lymphomamentioning

confidence: 99%

Malignant tumours of the small intestine: a review of histopathology, multidetector CT and MRI aspects

Anzidei¹,

Napoli²,

Zini³

et al. 2011

BJR

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“…On computed tomography (CT), typically presents as a homogenous density mass causing mural thickening and separation of adjacent small bowel loops. 5 The treatment protocols are unclear. Surgical resection should be applied for localized disease.…”

Section: Dıscussıonmentioning

confidence: 99%

A rare ethiology of acute abdomen syndrome: perforation of the small intestinal lymphoma

Altıntoprak¹,

Dikicier²,

Yürümez³

et al. 2011

Sakarya Med J

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Gastrointestinal sistem primer ekstranodal lenfomaların en sık görüldüğü yer olmasına rağmen primer intestinal lenfomalar nadir karşılaşılan klinik durumlardır. İntestinal lenfomalar genellikle non-spesifik ve kronik abdominal şikayetlerle ortaya çıkarlar. Bu yazıda acil servise ani başlayan şiddetli karın ağrısı şikâyeti ile başvuran perfore olmuş ince barsak lenfoma olgusunu sunmayı amaçladık.

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“…These malignant strictures are usually rigid, with a fixed, unchanging appearance during compression. On CT, small bowel adenocarcinomas may manifest as a discrete tumor mass, annular narrowing with abrupt concentric or irregular ‘overhanging edges' or an ulcerative lesion [18]. Endoscopic diagnosis of adenocarcinomas remains rare.…”

Section: Adenocarcinoma Of the Small Bowelmentioning

confidence: 99%

“…While most GISTs are located in the stomach, 30% of GISTs are found in the small bowel [18]. A characteristic of GISTs is their extraluminal growth [19,22].…”

Section: Gistsmentioning

confidence: 99%

See 1 more Smart Citation

Small Bowel Neoplasias: Current Options for Diagnosis, Staging and Therapeutic Management

Fry¹,

Gutiérrez²,

Jovanović³

et al. 2013

Gastrointest Tumors

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Although small bowel polyps and tumors are rare, their incidence has increased significantly over the past 30 years. Small bowel malignancies can be classified depending upon their cellular origin into four principal histologic types: adenocarcinomas, lymphomas, neuroendocrine tumors or carcinoids and lymphomas, which also include gastrointestinal stromal tumors. The relative ‘rarity' of these tumors has led to stagnation in the development of effective curative or adjuvant therapies. Thus, the prognosis of most of these tumors is still dismal. Nevertheless, hope is now on the horizon as new methods such as capsule endoscopy and balloon-assisted enteroscopy have contributed to a rise in the diagnosis of these lesions and a diagnosis at earlier stages. Using balloon-assisted enteroscopy methods it is possible to resect most small bowel polyps such as adenomas and hamartomas. Improved imaging methods have led to a better understanding of these pathologies and hopefully will bring new hopes in therapy. In addition, multi-center studies are being performed to determine the best therapeutic options for small bowel tumors. Key Message New imaging techniques such as capsule endoscopy and balloon-assisted endoscopy have facilitated the early diagnosis of small bowel malignancies, leading to a better understanding of the biology of these tumors and to improved clinical outcomes for the patient. Practical Implications Although relatively rare, the incidence of tumors and polyps in the small intestine has increased over the past 20 years. The use of endoscopic or radiologic techniques is crucial for the detection and resection of polyps. It is highly recommended to perform a submucosal injection of epinephrine-saline solution prior to endoscopic resection. Due to their non-specific symptoms, neuroendocrine tumors are often diagnosed in advanced stages; surgical excision of the primary tumor is key to a better prognosis. The main therapies for neuroendocrine tumors are surgery, chemoembolization, chemotherapy and the use of somatostatin analogues. Small bowel adenocarcinomas are extremely rare but can be highly fatal. Surgical resection is still the core treatment, though fluoropyrimidine and oxaliplatin-based chemotherapy have shown beneficial effects for the treatment of metastatic disease. Amongst the gastrointestinal stromal tumors, 30% are located in the small intestine. The management of gastrointestinal stromal tumors requires a combination of surgery, pathology techniques and pharmacological interventions, including the use of tyrosine kinase inhibitors.

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Diagnosis and staging of small bowel tumours

Abstract: Small bowel neoplasms comprise only 1% of gastrointestinal neoplasms. Despite their rarity, it is important to diagnose small bowel tumours early to maximize patient survival.

Cited by 56 publications

References 14 publications

Malignant tumours of the small intestine: a review of histopathology, multidetector CT and MRI aspects

Malignant tumours of the small intestine: a review of histopathology, multidetector CT and MRI aspects

A rare ethiology of acute abdomen syndrome: perforation of the small intestinal lymphoma

Small Bowel Neoplasias: Current Options for Diagnosis, Staging and Therapeutic Management

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