Diagnosis and prevalence of uterine leiomyomata in female chimpanzees (<i>Pan troglodytes</i>)

Videan, Elaine N.; Satterfield, William C.; Buchl, Stephanie J.; Lammey, Michael L

doi:10.1002/ajp.20947

Cited by 15 publications

(21 citation statements)

References 19 publications

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“…This animal had a large cervical fibroid that caused severe vaginal bleeding. In contrast to a previous study, 90 we were unable to detect any difference in the incidence of leiomyoma among animals on different contraceptive methods. However, we had limited data available, so it would be unwise to draw definitive conclusions about contraceptive use from our data.…”

Section: Discussioncontrasting

confidence: 99%

Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees

et al. 2016

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Chimpanzees (Pan troglodytes) have served as an important model for studies of reproductive diseases and aging-related disorders in humans. However, limited information is available about spontaneously occurring reproductive tract lesions in aging chimpanzees. In this article, the authors present histopathologic descriptions of lesions identified in the reproductive tract, including the mammary gland, of 33 female and 34 male aged chimpanzees from 3 captive populations. The most common findings in female chimpanzees were ovarian atrophy, uterine leiomyoma, adenomyosis, and endometrial atrophy. The most common findings in male chimpanzees were seminiferous tubule degeneration and lymphocytic infiltrates in the prostate gland. Other less common lesions included an ovarian granulosa cell tumor, cystic endometrial hyperplasia, an endometrial polyp, uterine artery hypertrophy and mineralization, atrophic vaginitis, mammary gland inflammation, prostatic epithelial hyperplasia, dilated seminal vesicles, a sperm granuloma, and lymphocytic infiltrates in the epididymis. The findings in this study closely mimic changes described in the reproductive tract of aged humans, with the exception of a lack of malignant changes observed in the mammary gland and prostate gland.

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Section: Discussioncontrasting

confidence: 99%

Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees

et al. 2016

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“…158,266 No published reports on arthritis in captive bonobos were found, and the only case in the Bonobo SSP pathology database with a diagnosis of arthritis was a 54 yo female with severe OA of the right hip and mild degenerative changes in the right knee; she died of cardiomyopathy. Since the next-oldest animals in the database are only in their 30s, it may be that OA is a late life event in this species.…”

Section: Arthritis In Captive Apesmentioning

confidence: 99%

“…39,109,267 Increasing age (>30 y) was associated with increased prevalence. Ovarian neoplasms in chimpanzees include ''fibrothecomas'' in 2 animals, 39 and 48 yo.…”

Section: Female Reproductive Tract Lesionsmentioning

confidence: 99%

Comparative Pathology of Aging Great Apes

2015

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The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives. Despite the many similarities, there are significant differences in aging among apes, including the human ape. Common to all are dental attrition, periodontitis, tooth loss, osteopenia, and arthritis, although gout is uniquely human and spondyloarthropathy is more prevalent in apes than humans. Humans are more prone to frailty, sarcopenia, osteoporosis, longevity past reproductive senescence, loss of brain volume, and Alzheimer dementia. Cerebral vascular disease occurs in both humans and apes. Cardiovascular disease mortality increases in aging humans and apes, but coronary atherosclerosis is the most significant type in humans. In captive apes, idiopathic myocardial fibrosis and cardiomyopathy predominate, with arteriosclerosis of intramural coronary arteries. Similar cardiac lesions are occasionally seen in wild apes. Vascular changes in heart and kidneys and aortic dissections in gorillas and bonobos suggest that hypertension may be involved in pathogenesis. Chronic kidney disease is common in elderly humans and some aging apes and is linked with cardiovascular disease in orangutans. Neoplasms common to aging humans and apes include uterine leiomyomas in chimpanzees, but other tumors of elderly humans, such as breast, prostate, lung, and colorectal cancers, are uncommon in apes. Among the apes, chimpanzees have been best studied in laboratory settings, and more comparative research is needed into the pathology of geriatric zoo-housed and wild apes. Increasing longevity of humans and apes makes understanding aging processes and diseases imperative for optimizing quality of life in all the ape species.

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“…OA refers to a form of chronic joint inflammation caused by deterioration of joint cartilage, and poses a serious threat to human health [19,20]. The pathogenesis of OA has not yet been fully elucidated until now.…”

Section: Discussionmentioning

confidence: 99%

Down-regulation of programmed cell death 5 by insulin-like growth factor 1 in osteoarthritis chondrocytes

Che

Xie

et al. 2013

International Orthopaedics (SICOT)

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Purpose The aim of this study was to investigate the expression of insulin-like growth factor (IGF)-1 and programmed cell death 5 (PDCD5) in osteoarthritis chondrocytes, and to explore the potential correlation between them in the apoptosis process of osteoarthritis chondrocytes. Methods Patients with knee osteoarthritis were placed into four categories according to radiological staging. The mRNA and protein levels of IGF-1 and PDCD5 in osteoarthritis chondrocytes were respectively detected by quantitative reverse transcriptase polymerase chain reaction (qPCR) and western blotting. In addition, IGF-1 and PDCD5 protein expression in chondrocytes were also measured by immunohistochemistry. Apoptotic cells were measured by TUNEL staining. Results Both the mRNA and protein levels of IGF-1 were down-regulated, while the levels of PDCD5 were upregulated, and the mRNA and protein levels of IGF-1 were negatively correlated with those of PDCD5, respectively. The apoptotic cell was significantly increased in osteoarthritis chondrocytes compared with control. Importantly, the apoptosis rate was positively correlated with PDCD5 protein expression and negatively correlated with IGF-1 protein expression Conclusions We concluded that IGF-1 may down-regulate the expression of PDCD5 and thus inhibit the apoptosis of osteoarthritis chondrocytes.

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Diagnosis and prevalence of uterine leiomyomata in female chimpanzees (Pan troglodytes)

Cited by 15 publications

References 19 publications

Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees

Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees

Comparative Pathology of Aging Great Apes

Down-regulation of programmed cell death 5 by insulin-like growth factor 1 in osteoarthritis chondrocytes

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