Diagnosis and Management of Malignant Melanoma in Store-and-Forward Teledermatology

Wang, Melinda; Gendreau, James L; Gemelas, Jordan; Capulong, Dana; Lau, Clayton; Mata-Diaz, Sandra; Bratten, Dustin M; Dougall, Brittany; Markham, Craig; Raugi, Gregory J.

doi:10.1089/tmj.2017.0009

Cited by 26 publications

(21 citation statements)

References 15 publications

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“…Melanoma is a multifactorial tumor arising from an interplay between environmental exposure and genetic susceptibility 4 , and UV exposure is considered to be the most important risk factor 5 . Early detection and timely treatment of melanoma are considered to be the two most critical factors in reducing mortality 6 . Compared to other tumors, melanoma has the advantage of cutaneous location, which allows its early detection.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Circ_0002770, acting as a competitive endogenous RNA, promotes proliferation and invasion by targeting miR-331-3p in melanoma

et al. 2020

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Melanoma is a kind of tumor that originates from melanocytes and is characterized by chemoresistance and distant metastasis. Although the complete pathogenesis of melanoma remains unclear, increasing evidence suggests that circular RNAs (circRNAs) may be involved. In the present study, we identified a circular RNA, circ_0002770, which is produced from the well-known oncogene MDM2, and was sharply increased in melanoma and correlated with a poor prognosis. Knockdown of circ_0002770 suppressed melanoma cell invasion, migration and proliferation. Mechanistically, circ_0002770 acted as a sponge of miR-331-3p and could indirectly regulate DUSP5 and TGFBR1. Inhibition of miR-331-3p reversed the inhibitory effect of si-circ_0002770 on melanoma cell proliferation and invasion. In vivo evidence further confirmed that silencing circ_0002770 inhibited melanoma tumor formation. In conclusion, circ_0002770 facilitated melanoma cell proliferation, invasion and migration by sponging miR-331-3p and modulating DUSP5 and TGFBR1.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Circ_0002770, acting as a competitive endogenous RNA, promotes proliferation and invasion by targeting miR-331-3p in melanoma

et al. 2020

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“…A systematic review found the diagnostic accuracy of face‐to‐face dermatology consultation (67%–85% agreement with reference standard, Cohen κ , 0.90) was higher than teledermatology (51%–85% agreement with reference standard, Cohen κ , 0.41–0.63) for the diagnosis of skin cancer (Finnane et al., 2017). For melanoma specifically, in a cohort study of 7,960 veterans among whom 61 melanomas were detected, store‐and‐forward teledermatology readers correctly diagnosed 45 (74%) and managed 57 (93%) lesions, which was comparable to published rates of face‐to‐face accuracy (Wang et al., 2017).…”

Section: Teledermatologysupporting

confidence: 63%

The role of technology in melanoma screening and diagnosis

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Cortez

et al. 2020

Pigment Cell Melanoma Res

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Melanoma presents challenges for timely and accurate diagnosis. Expert panels have issued risk‐based screening guidelines, with recommended screening by visual inspection. To assess how recent technology can impact the risk/benefit considerations for melanoma screening, we comprehensively reviewed non‐invasive visual‐based technologies. Dermoscopy increases lesional diagnostic accuracy for both dermatologists and primary care providers; total body photography and sequential digital dermoscopic imaging also increase diagnostic accuracy, are supported by automated lesion detection and tracking, and may be best suited to use by dermatologists for longitudinal follow‐up. Specialized imaging modalities using non‐visible light technology have unproven benefit over dermoscopy and can be limited by cost, access, and training requirements. Mobile apps facilitate image capture and lesion tracking. Teledermatology has good concordance with face‐to‐face consultation and increases access, with increased accuracy using dermoscopy. Deep learning models can surpass dermatologist accuracy, but their clinical utility has yet to be demonstrated. Technology‐aided diagnosis may change the calculus of screening; however, well‐designed prospective trials are needed to assess the efficacy of these different technologies, alone and in combination to support refinement of guidelines for melanoma screening.

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“…Teledermatology and teledermoscopy demonstrates good accuracy when provided via video consultations (real-time) or transmitting via store-and-forward still digital macro or dermoscopy images, or hybrid combinations of both. 3–5 Teledermatology has been evaluated for skin cancer early detection, lesion follow-up, and many other skin conditions such as rashes and wounds, 6 and diagnosis and monitoring of acne 7 and psoriasis. 8 Teledermatology services have consistently demonstrated reduced waiting times for assessment and diagnosis, 9 increased access to services in rural and remote areas 10 and high patient satisfaction.…”

Section: Introductionmentioning

confidence: 99%

Evaluating healthcare practitioners’ views on store-and-forward teledermoscopy services for the diagnosis of skin cancer

et al. 2019

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Objective The aim of the study is to evaluate healthcare practitioners’ views on and satisfaction with (i) digital image acquisition and storage and (ii) store-and-forward teledermoscopy services for the diagnosis of skin cancer in their clinical practice. Methods An online survey was conducted among 59 healthcare practitioners (GPs ( n =17), dermatologists ( n =22), dermatology registrars ( n =18), a dermatology research fellow ( n =1) and a plastic surgeon ( n =1)) to assess usability of digital image acquisition and storage for when the imaging process is conducted by the healthcare practitioners themselves, or by their patients. The study identifies the enablers and barriers of this emerging mode of medical practice. A thematic analysis was used to extract key themes from open-ended responses, which involved identifying themes and patterns within and across participants. Results Thirty-four healthcare practitioners (58%) had previously used a mobile dermatoscope within their practice. Participants most appreciated its use in their practice for lesion monitoring (59%) and record keeping (39%). Challenges reported were the increased time to support the additional workload (45%), technical issues (33%) and cost of equipment (27%). Practitioners were unsure (36%) or did not advocate teledermoscopy for direct-to-consumer use (41%). Only 23% supported the use of direct-to-consumer teledermoscopy. Conclusion While most practitioners are receptive to mobile teledermoscopy, there was less support for patient-initiated use, whereby the patient controls the imaging process. As technology improves rapidly it is important to evaluate practitioners’ acceptance and satisfaction of evolving telehealth services, moving forward with models of practice where healthcare practitioners and other healthcare providers will feel comfortable engaging in telehealth services.

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Diagnosis and Management of Malignant Melanoma in Store-and-Forward Teledermatology

Abstract: Diagnosis and management of melanoma in SFT is comparable to FTF care.

Cited by 26 publications

References 15 publications

RETRACTED ARTICLE: Circ_0002770, acting as a competitive endogenous RNA, promotes proliferation and invasion by targeting miR-331-3p in melanoma

RETRACTED ARTICLE: Circ_0002770, acting as a competitive endogenous RNA, promotes proliferation and invasion by targeting miR-331-3p in melanoma

The role of technology in melanoma screening and diagnosis

Evaluating healthcare practitioners’ views on store-and-forward teledermoscopy services for the diagnosis of skin cancer

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