Diagnosis and management of malignant sublingual gland tumors: a narrative review

Park, Minhae; Cho, Junhun; Ryu, Junsun; Jeong, Han‐Sin

doi:10.21037/gs-21-620

Cited by 7 publications

(6 citation statements)

References 28 publications

(91 reference statements)

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“…In the current study, the 5‐year OS and DFS of the 79 patients with MSLGT was 85.7% and 71.7%, respectively, while that in other retrospective studies of MSLGT ranged from 69% to 77.7%. (Kojima et al, 2020; Lee et al, 2016; Liu et al, 2017; Park, Cho, et al, 2021). Lee et al (2016) analyzed the surveillance, epidemiology, and end results (SEER) database and found that the 5‐year OS for 210 patients was 69%, which is lower than our estimation (Lee et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…MSLGT has some potential for cervical nodal metastasis and distant metastasis, and some patients may suffer from local and regional recurrence. A few of patients with MSLGT pathological types are at some risk of cervical nodal metastasis, with a documented metastasis rate of up to 60% for non‐ACC malignant sublingual gland tumors (Park, Cho, et al, 2021). However, ACC is more frequent among sublingual gland malignancies therefore, cervical nodal metastasis of MSLGT is not that common when compared with other major salivary gland malignancies (Liu, Lu, et al, 2022; Lombardi et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Malignant sublingual gland tumors: A single‐center retrospective analysis of 79 patients

Liu

et al. 2023

Oral Diseases

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ObjectivesTo analyze and summarize the clinicopathological features, risk factors for cervical nodal metastasis, and prognostic factors of malignant sublingual gland tumors (MSLGT).MethodsPatients diagnosed with MSLGT were retrospectively reviewed from January 2005 to December 2017 at Shanghai Ninth Hospital. The clinicopathological features were summarized, and the correlations between clinicopathological parameters, cervical nodal metastasis, and local–regional recurrence were evaluated using the Chi‐square test. Kaplan–Meier method and Cox regression analysis were performed to assess the survival and independent prognostic factors.ResultsSeventy‐nine patients were included, and the 5‐year overall survival and disease‐free survival rates was 85.7% and 71.7%, respectively. Gender and clinical tumor stage were risk factors for cervical nodal metastasis. Tumor size and pathological lymph node (LN) stage were independent prognostic factors for adenoid cystic carcinoma (ACC) of the sublingual gland; while age, pathological LN stage, and distant metastasis were prognostic factors for patients with non‐ACC of the sublingual gland. Patients with higher clinical stage were more likely to undergo tumor recurrence.ConclusionsMalignant sublingual gland tumors are rare, and neck dissection should be performed in male MSLGT patients with higher clinical stage. Among patients with both ACC and non‐ACC MSLGT patients, pN+ indicate a poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Malignant sublingual gland tumors: A single‐center retrospective analysis of 79 patients

Liu

et al. 2023

Oral Diseases

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“…However, the preservation of the ductal system must be considered; otherwise, excision of the ipsilateral submandibular gland is recommended. 33 For large tumors, en bloc resection is the common first option. Additionally, lingual nerve ablation is usually required to achieve a negative margin.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database study

Qin,

Wu,

et al. 2023

J Int Med Res

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Objective To identify the clinical features and prognostic factors for sublingual gland carcinoma. Methods This was a case–control study. Patients with surgically treated sublingual gland carcinoma were retrospectively included in the Surveillance, Epidemiology and End Results database and divided into adenoid cystic carcinoma (ACC) and non-ACC groups. Primary outcome variables were disease-specific survival (DSS) and overall survival (OS). Prognostic factors for each group were analyzed using Cox models. Results We included 251 patients (115 men and 136 women). Compared with the non-ACC group, the ACC group had a larger average tumor size and received more adjuvant radiotherapy. In patients with ACC, the pathologic grade had an independent impact on DSS and OS, and patients who were undergoing adjuvant chemotherapy had worse DSS than those who were not receiving chemotherapy. In the non-ACC group, pathologic grade IV, lymph node metastasis, and adjuvant chemotherapy were associated with poor DSS and OS, and tumor extension predicted worsening DSS. Conclusions In sublingual gland carcinoma, the pathologic grade and adjuvant chemotherapy were the most important prognostic factors, whereas lymph node metastasis had a negative impact in non-ACC patients but not in ACC patients.

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“…Chemotherapeutics for salivary glands remain a poor option; the last clinical trial looking into doxorubicin to treat advanced carcinoma was conducted in 1996 and reported a meager 27% response rate ( 190 ). More recent studies looking at antibody therapies have been equally disappointing; although anti-EGFR and anti-HER2 therapies make some improvement, many patients ultimately develop resistance and do not reach remission ( 191 , 192 ). Though other therapeutics are under investigation, a better understanding of critical genes that can drive a terminally differentiated salivary gland duct or acinar cell back to a stem-like state would likely facilitate the development of more effective therapeutics ( 193 ).…”

Section: Discussionmentioning

confidence: 99%

Sci-Seq of Human Fetal Salivary Tissue Introduces Human Transcriptional Paradigms and a Novel Cell Population

et al. 2022

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Multiple pathologies and non-pathological factors can disrupt the function of the non-regenerative human salivary gland including cancer and cancer therapeutics, autoimmune diseases, infections, pharmaceutical side effects, and traumatic injury. Despite the wide range of pathologies, no therapeutic or regenerative approaches exist to address salivary gland loss, likely due to significant gaps in our understanding of salivary gland development. Moreover, identifying the tissue of origin when diagnosing salivary carcinomas requires an understanding of human fetal development. Using computational tools, we identify developmental branchpoints, a novel stem cell-like population, and key signaling pathways in the human developing salivary glands by analyzing our human fetal single-cell sequencing data. Trajectory and transcriptional analysis suggest that the earliest progenitors yield excretory duct and myoepithelial cells and a transitional population that will yield later ductal cell types. Importantly, this single-cell analysis revealed a previously undescribed population of stem cell-like cells that are derived from SD and expresses high levels of genes associated with stem cell-like function. We have observed these rare cells, not in a single niche location but dispersed within the developing duct at later developmental stages. Our studies introduce new human-specific developmental paradigms for the salivary gland and lay the groundwork for the development of translational human therapeutics.

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Diagnosis and management of malignant sublingual gland tumors: a narrative review

Cited by 7 publications

References 28 publications

Malignant sublingual gland tumors: A single‐center retrospective analysis of 79 patients

Malignant sublingual gland tumors: A single‐center retrospective analysis of 79 patients

Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database study

Sci-Seq of Human Fetal Salivary Tissue Introduces Human Transcriptional Paradigms and a Novel Cell Population

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