Diagnosing Schistosomiasis

Rabello, Ana

doi:10.1590/s0074-02761997000500021

Cited by 32 publications

(22 citation statements)

References 28 publications

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“…The KatoKatz thick-smear technique (105) is widely used, as it is costeffective, easy to learn, and not technically difficult and requires limited special resources (33,157). This rapid, simple, and inexpensive method requires 40 to 50 mg of feces and is used widely in community surveys, in field studies, and in the national control program in China to determine the burden of eggs in feces (162,187,228).…”

Section: Parasitological Methodsmentioning

confidence: 99%

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

et al. 2010

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SUMMARY The potential impact of the Three Gorges Dam (TGD) on schistosomiasis transmission in China has invoked considerable global concern. The TGD will result in changes in the water level and silt deposition downstream, favoring the reproduction of Oncomelania snails. Combined with blockages of the Yangtze River's tributaries, these changes will increase the schistosomiasis transmission season within the marshlands along the middle and lower reaches of the Yangtze River. The changing schistosome transmission dynamics necessitate a comprehensive strategy to control schistosomiasis. This review discusses aspects of the epidemiology and transmission of Schistosoma japonicum in China and considers the pathology, clinical outcomes, diagnosis, treatment, immunobiology, and genetics of schistosomiasis japonica together with an overview of current progress in vaccine development, all of which will have an impact on future control efforts. The use of synchronous praziquantel (PZQ) chemotherapy for humans and domestic animals is only temporarily effective, as schistosome reinfection occurs rapidly. Drug delivery requires a substantial infrastructure to regularly cover all parts of an area of endemicity. This makes chemotherapy expensive and, as compliance is often low, a less than satisfactory control option. There is increasing disquiet about the possibility that PZQ-resistant schistosomes will develop. Consequently, as mathematical modeling predicts, vaccine strategies represent an essential component in the future control of schistosomiasis in China. With the inclusion of focal mollusciciding, improvements in sanitation, and health education into the control scenario, China's target of reducing the level of schistosome infection to less than 1% by 2015 may be achievable.

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Section: Parasitological Methodsmentioning

confidence: 99%

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

et al. 2010

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“…19 This diagnosis was only 12 years after Schistosoma haematobium had been discovered by the German physician Bilharz in Egypt in 1851. 20 Case reports between 1864 and 1899 revealed how children, mostly boys between the ages of 3 and 16, were infected with schistosomiasis in the Eastern Cape. 19 Transmission among the boys was as a result of recreational swimming, contact with infested water in open pools, farm dams and furrows.…”

Section: A Brief History Of Schistosomiasis In South Africamentioning

confidence: 99%

review of the control of schistosomiasis in South Africa

Magaisa¹,

Taylor²,

Kjetland³

et al. 2018

S. Afr. J. Sci.

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Schistosomiasis is the second most important tropical disease in the world in terms of public health impact. In South Africa, more than 4 million people are estimated to be infected with schistosomiasis. School-age children usually have the highest prevalence and intensity of infection. Schistosoma haematobium may result in female genital schistosomiasis which presents as inflammation and ulceration of the genital mucosa and pathological blood vessels. These effects may increase the susceptibility of women with female genital schistosomiasis to HIV. Praziquantel is the drug used to treat schistosomiasis and it is best to treat people during the early stages of infection, before female genital schistosomiasis presents as lesions and sandy patches, as there currently is no treatment for these symptoms. Schistosomiasis is not regarded as a serious public health issue in South Africa despite evidence revealing the seriousness of the disease. In areas endemic for schistosomiasis, the World Health Organization recommends regular mass treatment of all school-age children. In 2001, South Africa became a signatory to the World Health Assembly resolution 54.19 which urged all member states to achieve the minimum goal of 75% treatment coverage in school-age children at risk by 2010. This goal was not achieved in South Africa, despite efforts made by the Department of Health, such as the first statutory school-based geohelminth control programme in the province of KwaZulu-Natal. However, this programme has not been continued. Therefore, there is still much work to be done in order to control and decrease the prevalence of schistosomiasis in endemic areas.

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“…Reliable and sensitive diagnostic procedures are crucial for decisions on individual or community treatment, estimation of prognosis and assessment of morbidity, control measures, and evaluation of chemotherapy of schistosomiasis (Berquist, 1992;Feldmeier and Poggensee, 1993;Rabello, 1997). Microscopic demonstration of the parasite's eggs in faeces or urine remains the most widespread tool to diagnose schistosomiasis, mainly due to its low operational costs (Rabello et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Determination of the specificity of monoclonal antibodies against Schistosoma mansoni CAA glycoprotein antigen using neoglycoconjugate variants

Souza

Remoortere

Hokke

et al. 2005

Biological Chemistry

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The immunogenic O-glycan of circulating anodic antigen (CAA) is a high-molecular-mass polysaccharide with the unique ™6)-wb-D-GlcpA-(1™3)x-b-D-GalpNAc-(1™ repeating unit. To obtain information at the molecular level about the specificity of monoclonal antibodies against CAA, the immunoreactivity of two series of bovine serum albumin-coupled synthetic oligosaccharides related to the CAA O-glycan was monitored using ELISA and surface plasmon resonance spectroscopy. The importance of the axial hydroxyl group of b-

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Diagnosing Schistosomiasis

Abstract: The ideal diagnostic method for schistosomiasis detection seems to be still far from available. Pau

Cited by 32 publications

References 28 publications

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

review of the control of schistosomiasis in South Africa

Determination of the specificity of monoclonal antibodies against Schistosoma mansoni CAA glycoprotein antigen using neoglycoconjugate variants

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