Diacetoxyscirpenol and some related compounds

Dawkins, A. W.; Grove, John Frederick; Tidd, B. K.

doi:10.1039/c19650000027

Cited by 12 publications

(4 citation statements)

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“…The two compounds could inhibit egg hatch and immobilize second-stage juveniles of nematode M. incognita [73]. The two trichothecene compounds have been found in several other Fusarium species [74][75][76][77]. A new macrocyclic lactone derivative paeciloxazine (89) with the pyrrolobenzoxazine skeleton was isolated from the culture broth of Paecilomyces sp.…”

Section: Terpenoidsmentioning

confidence: 99%

Nematicidal Substances from Fungi

Zhang²,

Xu³

et al. 2007

BIOT

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This review summarizes the 179 compounds from fungi that have shown to possess nematicidal activities. These compounds belong to diverse chemical groups and they are mainly isolated from a variety of deuteromycete, ascomycete and basidiomycete fungi. Some of them have been patented as nematicidal agents. We review and classify these compounds based on their structural types. Their nematicidal activities are described and their potential roles in natural environments and in the biocontrol of nematodes are discussed.

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Section: Terpenoidsmentioning

confidence: 99%

Nematicidal Substances from Fungi

Zhang²,

Xu³

et al. 2007

BIOT

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“…Isolates of F. tricinctum produce a very potent toxin that has been charac- terized as 3-hydroxy-4, 15-diacetoxy-8-(3methylbutyryloxy) 12, 13-epoxy-A 9 trichothecene and has been designated as T-2 toxin (Bamburger et al, 1968). Another major toxic metabolite of F. tricinctum and F. roseum is diacetoxyscirpenol (3-hydroxy-4,15 diacetoxy-12,13-epoxy-A 9 -trichothecene) (Dawkins et al, 1965). These mycotoxins are colorless crystals with low water solubility.…”

Section: Introductionmentioning

confidence: 99%

Subacute Toxicity of T-2 Toxin in Broiler Chicks ,

Mirocha

Kurtz

et al. 1977

Poultry Science

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Purified T-2 toxin was fed in a diet to broiler chicks from one day to 9 weeks of age in concentrations of 0, 0.2, 0.4, 2.0, and 4.0 p.p.m. to evaluate the subacute toxicity of the toxin. There were 36 chicks per T-2 concentration and 12 chicks were necropsied at 3 week intervals.The weight gain of chicks fed a diet containing 4 p.p.m. T-2 toxin was significantly (P < 0.05) less than that of chicks fed the control diet or a diet containing 0.4 p.p.m. T-2 toxin while feed conversion was similar between treatments. The weight gain was most sensitively affected by the toxin during the first 3-week period. The heart weight was significantly (P < 0.05) increased in chicks fed 1 and 2 p.p.m. T-2 toxin, but not in chicks fed 4 p.p.m. The liver and gizzard weights were not influenced by the dietary T-2 toxin.Oral lesions were observed in chicks fed the diet containing 4 p.p.m. T-2 toxin from the second week and nearly 75% of the total chicks in this treatment developed oral lesions after the 3rd week. The lesions were a circumscribed proliferative yellow caseous plaque type, and occurred at the margin of the beak, mucosa of the hard palate and angle of the mouth, and tongue. The severity and incidence were proportional to the amount of T-2 toxin in the diet. There were no outward clinical or pathological signs except that a few birds fed 4 p.p.m. T-2 toxin showed necrotic lesions on the mucosal lining of the gizzard.No abnormal changes were found in the bone marrow. As compared with control chicks, there was no marked change in blood components (hematocrit, hemoglobin, erythrocyte, leukocyte, leukocyte differential count) in T-2 treated chicks. In chicks fed high concentrations of T-2 toxin, the serum levels of alkaline phosphatase, LDH and cholesterol tended to decrease while uric acid increased.

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“…Ein Signal bei 1,77 ppm ist der 16-Methylgruppe und ein breites Signal bei 5,3 ppm dem Vinylproton an C-8 zuzuordnen. Die Wasserstoffe an C-2, C-3 und C-11 verursachen Dublette bei 6= 4,27,5,56,3,99 rnit J = 3,5,3,5 und 4,O. Die Rruckeiibildung von C-10 nach C-13, die in analoger Weise aucli am [I] beobachtet worden ist, liess sich ebenso an Triacetoxyscirpenol…”

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