2003
DOI: 10.1590/s0004-27302003000300003
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Abstract: Diabetic nephropathy (DN) is responsible for the increasing number of patients on dialysis in developing countries, and is already the most common cause of renal replacement therapy in the developed ones. In this manuscript, we review the risk factors and point out strategies to prevent this microvascular complication in type 2 diabetic patients (DM2). There are some known genetic and non-genetic risk factors related to the development and progression of DN in DM2 patients. Candidate genes have been analysed, … Show more

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Cited by 17 publications
(127 citation statements)
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References 121 publications
(127 reference statements)
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“…Similar to other countries, chronic kidney disease has been an important public health problem in Brazil. It is estimated that at least one third of Brazilians with type 2 diabetes are affected by DN [34,35]. …”
Section: Resultsmentioning
confidence: 99%
“…Similar to other countries, chronic kidney disease has been an important public health problem in Brazil. It is estimated that at least one third of Brazilians with type 2 diabetes are affected by DN [34,35]. …”
Section: Resultsmentioning
confidence: 99%
“…A combination of environmental and clinical factors in genetically predisposed individuals have been suggested to be involved in DKD, including persistent hyperglycaemia, arterial hypertension and/or dyslipidaemia 37. In addition, familial aggregation of nephropathy in T2DM has been reported in several populations 38.…”
Section: Discussionmentioning
confidence: 99%
“…DN is histologically defined by thickening of the glomerular basement membrane, increased fractional mesangial volume, and podocyte abnormalities [ 2 ]. Hyperglycemia, hypertension and proteinuria are the main insults that cause structural abnormalities in a diabetic kidney [ 1 , 4 - 6 ].…”
Section: Introductionmentioning
confidence: 99%