Diabetic ketoacidosis Predictors of outcome in a pediatric intensive care unit of a developing country*

Jayashree, Muralidharan; Singhi, Sunit

doi:10.1097/01.pcc.0000137987.74235.5e

Cited by 88 publications

(72 citation statements)

References 30 publications

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“…[7] Most common presenting complaints was fever followed by vomiting and rapid breathing, in contrast to impaired level of consciousness as reported by jayshree etal. [10] History of symptoms of polyuria and polydipsia were given in only 5 (16.6%) cases as opposed to other studies [3,7] which reported it to be 25% and 85% respectively. Most of our patients had new onset type 1DM.…”

Section: Resultsmentioning

confidence: 60%

Clinical Profile and Outcome of Diabetic Ketoacidosis in Children at Tertiary Care Hospital

Varshney¹,

Varshney²,

Mehr³

et al. 2015

jemds

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OBJECTIVE:To study the clinical profile of children admitted with diabetic ketoacidosis (DKA) in Sri Aurobindo Institute of Medical Sciences (SAIMS) Indore. METHODS: We retrospectively analysed the case records of 30 children admitted with DKA to our intensive care unit, from Jan 2011-Jan 2015. Information regarding personal details, chief complaints, clinical features, laboratory parameters, management and outcome was recorded using a predesigned pro forma. RESULTS: The median age at presentation was 8 years (range 9months-13yrs); 12 boys and 18 girls were enrolled. Diabetes was newly diagnosed in 20 cases and known cases of type1 diabetes were 10. Commonest presenting complaints were fever (66%), rapid breathing (60%), vomiting (60%), and altered sensorium (26. 6%). Average length of PICU stay was 58. 6hrs. All of the cases had elevated HbA1c, except one. Co-morbities found were UTI in 12 (40%), dysentery in 2 (6. 6%), and viral hepatitis in1 (3. 33%). Cerebral edema was seen in 1 case. There was no mortality in our study. CONCLUSION: DKA in children if diagnosed early and managed timely has good outcome. Poor compliance is most important precipitating factor in known cases of T1DM.

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Section: Resultsmentioning

confidence: 60%

Clinical Profile and Outcome of Diabetic Ketoacidosis in Children at Tertiary Care Hospital

Varshney¹,

Varshney²,

Mehr³

et al. 2015

jemds

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show abstract

“…The mortality rate in DKA is between 0.15% and 0.35% in the developed countries, such as the United States of America, Canada and the UK (6)(7). This rate is between 3.4% and 13.4% in the countries such as India, Pakistan and Bangladesh (8)(9)(10)(11). These differences may be due to the differences in the duration of feeling bad before referring to a hospital, the improper treatments, and the differences in the medical care received by patients with DKA.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Patients with Diabetic Ketoacidosis in South of Iran

Ilkhanipoor¹

2017

JED

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“…[4][5][6][7][8][9][10][11][12][13][14] In this study group the mortality rate was 12.8%. The socio demographic factors like age group, sex, geographical area, consanguinity of parents was not significantly associated with mortality in this study.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for poor outcome in diabetic keto acidosis at the initial presentation among children with type 1 diabetes mellitus

PonJeba¹,

Varadarajan²

2018

Int J Contemp Pediatr

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Background: Diabetic keto acidosis (DKA) is a serious metabolic disorder among children with new onset Type 1 Diabetes mellitus and is associated with high morbidity and mortality. Objective of the present study was to assess the risk factors associated with mortality in DKA at its initial presentation among children with new onset type 1 diabetes mellitus (T1DM).Methods: A case control study was designed and conducted in the Institute of child Health and Hospital for children, Madras Medical College, Chennai from February 2013 to February 2015. All children admitted with DKA as initial presentation of type 1 Diabetes mellitus were enrolled for this study.Results: Out of 72 new cases of T1DM, diagnosed during the study period 47 children had DKA and 25 children presented without DKA. Of the 47 children 6 children died. On comparing risk factors for mortality in DKA at the initial presentation, delayed treatment(p-0.002), altered sensorium at presentation(p-0.04), high urea(p-0.014) creatinine(p-0.042), lower bicarbonates (p-0.035), higher sodium(p-0.025) and lower pH(p-0.009) were found to be significantly associated with mortality. Overall mortality in DKA at its initial presentation is 12.8%.Conclusions: Delay in therapy for DKA and presence of features of severe disease at admission are significant risk factors for mortality.

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Diabetic ketoacidosis Predictors of outcome in a pediatric intensive care unit of a developing country*

Abstract: Two thirds of children with diabetic ketoacidosis in our series had new-onset diabetes, and 13.2% died. Serum osmolality at admission was the most important predictor of death.

Cited by 88 publications

References 30 publications

Clinical Profile and Outcome of Diabetic Ketoacidosis in Children at Tertiary Care Hospital

Clinical Profile and Outcome of Diabetic Ketoacidosis in Children at Tertiary Care Hospital

Outcome of Patients with Diabetic Ketoacidosis in South of Iran

Risk factors for poor outcome in diabetic keto acidosis at the initial presentation among children with type 1 diabetes mellitus

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