Diabetic amyotrophy progressing to severe quadriparesis

Abstract

Diabetic amyotrophy is a distinctive form of diabetic neuropathy usually characterized by the abrupt onset of pain and asymmetric proximal leg weakness and wasting. Involvement of the upper limbs is unusual, and prognosis is said to be good. We describe two patients, each with type II diabetes mellitus, who presented with diabetic amyotrophy progressing to severe quadriparesis. One patient remains severely disabled. The clinical spectrum of diabetic amyotrophy includes progression to severe quadriparesis.

Guillain Barre syndrome as a manifestation of neurological melioidosis

“…Rarely acute quadriparesis may occur because of dyselectrolytemia,[8] and diabetic amyotrophy. [9] Further diabetic neuropathy manifests as pure sensory or sensorimotor neuropathy. However, predominant or pure motor neuron involvement including paralysis or weakness of extremities with generalized areflexia is suggestive of GBS.…”

Guillain Barre syndrome as a manifestation of neurological melioidosis

“…Rarely acute quadriparesis may occur because of dyselectrolytemia,[8] and diabetic amyotrophy. [9] Further diabetic neuropathy manifests as pure sensory or sensorimotor neuropathy. However, predominant or pure motor neuron involvement including paralysis or weakness of extremities with generalized areflexia is suggestive of GBS.…”

A Novel Cellular Defect in Diabetes

“…Diabetic myopathy, generally speaking, has been viewed as a consequence of underlying neuropathy (5,33). However, to our knowledge, there is no definitive evidence to suggest a causal relationship between diabetic neuropathy and myopathy.…”

Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms

“…Diabetic amyotrophy is described as a specific type of neuropathy where relatively sudden onset of pain and muscle weakness in the pelvic and thigh muscles occurs, symmetrically or asymmetrically, and is usually accompanied by loss of sensation (191,192). It is mentioned here as it may be confused with the peripheral neuropathy affecting limb musculature as we have described above.…”

Guillain Barre syndrome as a manifestation of neurological melioidosis

“…Rarely acute quadriparesis may occur because of dyselectrolytemia,[8] and diabetic amyotrophy. [9] Further diabetic neuropathy manifests as pure sensory or sensorimotor neuropathy. However, predominant or pure motor neuron involvement including paralysis or weakness of extremities with generalized areflexia is suggestive of GBS.…”

A Novel Cellular Defect in Diabetes

“…Diabetic myopathy, generally speaking, has been viewed as a consequence of underlying neuropathy (5,33). However, to our knowledge, there is no definitive evidence to suggest a causal relationship between diabetic neuropathy and myopathy.…”

Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms

“…Diabetic amyotrophy is described as a specific type of neuropathy where relatively sudden onset of pain and muscle weakness in the pelvic and thigh muscles occurs, symmetrically or asymmetrically, and is usually accompanied by loss of sensation (191,192). It is mentioned here as it may be confused with the peripheral neuropathy affecting limb musculature as we have described above.…”

Guillain Barre syndrome as a manifestation of neurological melioidosis

“…Rarely acute quadriparesis may occur because of dyselectrolytemia,[8] and diabetic amyotrophy. [9] Further diabetic neuropathy manifests as pure sensory or sensorimotor neuropathy. However, predominant or pure motor neuron involvement including paralysis or weakness of extremities with generalized areflexia is suggestive of GBS.…”

A Novel Cellular Defect in Diabetes

“…Diabetic myopathy, generally speaking, has been viewed as a consequence of underlying neuropathy (5,33). However, to our knowledge, there is no definitive evidence to suggest a causal relationship between diabetic neuropathy and myopathy.…”

Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms

“…Diabetic amyotrophy is described as a specific type of neuropathy where relatively sudden onset of pain and muscle weakness in the pelvic and thigh muscles occurs, symmetrically or asymmetrically, and is usually accompanied by loss of sensation (191,192). It is mentioned here as it may be confused with the peripheral neuropathy affecting limb musculature as we have described above.…”