Diabetes mellitus – an overview

Sonia, Thundiparambil Azeez; Sharma, Chandra P.

doi:10.1533/9781908818683.1

Cited by 10 publications

(8 citation statements)

References 205 publications

(192 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exenatide is a glucagon-like peptide 1 (GLP1) analog derived from exendin-4. It is a mimetic of incretin that has been used as an adjunctive therapeutic for type 2 diabetes mellitus [153,154]. Igoillo-Esteve et al [125] investigated the antioxidant properties of exenatide on iPSC-derived β cells and DRG sensory neurons obtained from patients with FRDA and FXN KIKO mice.…”

Section: Exenatidementioning

confidence: 99%

Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

Autosomal recessive cerebellar ataxias (ARCAs) are a heterogeneous group of rare neurodegenerative inherited disorders. The resulting motor incoordination and progressive functional disabilities lead to reduced lifespan. There is currently no cure for ARCAs, likely attributed to the lack of understanding of the multifaceted roles of antioxidant defense and the underlying mechanisms. This systematic review aims to evaluate the extant literature on the current developments of therapeutic strategies that target oxidative stress for the management of ARCAs. We searched PubMed, Web of Science, and Science Direct Scopus for relevant peer-reviewed articles published from 1 January 2016 onwards. A total of 28 preclinical studies fulfilled the eligibility criteria for inclusion in this systematic review. We first evaluated the altered cellular processes, abnormal signaling cascades, and disrupted protein quality control underlying the pathogenesis of ARCA. We then examined the current potential therapeutic strategies for ARCAs, including aromatic, organic and pharmacological compounds, gene therapy, natural products, and nanotechnology, as well as their associated antioxidant pathways and modes of action. We then discussed their potential as antioxidant therapeutics for ARCAs, with the long-term view toward their possible translation to clinical practice. In conclusion, our current understanding is that these antioxidant therapies show promise in improving or halting the progression of ARCAs. Tailoring the therapies to specific disease stages could greatly facilitate the management of ARCAs.

show abstract

Section: Exenatidementioning

confidence: 99%

Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Postprandial blood glucose levels can be reduced through the reduction in polysaccharides breakdown and digestion upon the inhibition of these enzymes. [167][168][169] Krishnasree & Ukkuru (2017) analyzed the antidiabetic activity of honey using in vitro α-amylase and α-glucosidase enzyme inhibition assays. 166 Trigona iridipennis honey, a type of stingless bee honey, demonstrated the strongest α-amylase and αglucosidase inhibitory properties than other multifloral honey species.…”

Section: Honey and Hyperglycemiamentioning

confidence: 99%

Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications

Ramli

Sukalingam

Kamaruzzaman

et al. 2021

DMSO

View full text Add to dashboard Cite

Metabolic syndrome (MetS) refers to the simultaneous presence of hypertension, hyperglycemia, dyslipidemia and/or visceral obesity, which predisposes a person to cardiovascular diseases and diabetes. Evidence suggesting the presence of direct and indirect associations between MetS and osteoporosis is growing. Many studies have reported the beneficial effects of polyphenols in alleviating MetS in in vivo and in vitro models through their antioxidant and anti-inflammation actions. This review aims to summarize the effects of honey (based on unifloral and multi-floral nectar sources) on bone metabolism and each component of MetS. A literature search was performed using the PubMed and Scopus databases using specific search strings. Original studies related to components of MetS and bone, and the effects of honey on components of MetS and bone were included. Honey polyphenols could act synergistically in alleviating MetS by preventing oxidative damage and inflammation. Honey intake is shown to reduce blood glucose levels and prevent excessive weight gain. It also improves lipid metabolism by reducing total cholesterol, triglycerides and low-density lipoprotein, as well as increasing high-density lipoprotein. Honey can prevent bone loss by reducing the adverse effects of MetS on bone homeostasis, apart from its direct action on the skeletal system. In conclusion, honey supplementation could be integrated into the management of MetS and MetS-induced bone loss as a preventive and adjunct therapeutic agent.

show abstract

“…Alpha-amylase is an enzyme responsible for hydrolysis of complex starch to oligosaccharides, whereas α-glucosidase hydrolyses oligosaccharides, trisaccharides and disaccharides into monosaccharides as the end product. It was well documented that inhibition of these enzymes was able to lower postprandial blood glucose levels [ 56 , 57 , 58 ]. In this regard, antidiabetic activity of honey was analyzed using in vitro α-amylase and α-glucosidase enzyme inhibition assays by Krishnasree & Mary (2017).…”

Section: Antidiabetic Effectsmentioning

confidence: 99%

A Review on the Protective Effects of Honey against Metabolic Syndrome

et al. 2018

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is a cluster of diseases comprising of obesity, diabetes mellitus, dyslipidemia, and hypertension. There are numerous pre-clinical as well as human studies reporting the protective effects of honey against MetS. Honey is a nutritional food low in glycemic index. Honey intake reduces blood sugar levels and prevents excessive weight gain. It also improves lipid metabolism by reducing total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL), which leads to decreased risk of atherogenesis. In addition, honey enhances insulin sensitivity that further stabilizes blood glucose levels and protects the pancreas from overstimulation brought on by insulin resistance. Furthermore, antioxidative properties of honey help in reducing oxidative stress, which is one of the central mechanisms in MetS. Lastly, honey protects the vasculature from endothelial dysfunction and remodelling. Therefore, there is a strong potential for honey supplementation to be integrated into the management of MetS, both as preventive as well as adjunct therapeutic agents.

show abstract

Diabetes mellitus – an overview

Cited by 10 publications

References 205 publications

Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review

Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review

Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications

A Review on the Protective Effects of Honey against Metabolic Syndrome

Contact Info

Product

Resources

About