Diabetes Mellitus: a Clinical Condition Associated with Metabolic Syndrome and Colorectal Cancer Risk

Brzački, Vesna; Nagorni, Aleksandar; Kallistratos, Manolis S.; Manolis, Athanasios; Lović, Dragan

doi:10.1007/s40495-019-00183-8

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…IGF-1 is a mitogenic factor that enhances cell growth and decreases cell death [ 27 , 31 ]. Moreover, chronic inflammation associated with diabetes favors carcinogenesis, malignant transformation, tumor growth, invasion and metastasis through the action of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (Il-6) [ 31 , 32 ].…”

Section: Risk Factorsmentioning

confidence: 99%

A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Sawicki

Ruszkowska

Danielewicz

et al. 2021

Cancers

437

247

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This review article contains a concise consideration of genetic and environmental risk factors for colorectal cancer. Known risk factors associated with colorectal cancer include familial and hereditary factors and lifestyle-related and ecological factors. Lifestyle factors are significant because of the potential for improving our understanding of the disease. Physical inactivity, obesity, smoking and alcohol consumption can also be addressed through therapeutic interventions. We also made efforts to systematize available literature and data on epidemiology, diagnosis, type and nature of symptoms and disease stages. Further study of colorectal cancer and progress made globally is crucial to inform future strategies in controlling the disease’s burden through population-based preventative initiatives.

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Section: Risk Factorsmentioning

confidence: 99%

A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Sawicki

Ruszkowska

Danielewicz

et al. 2021

Cancers

437

247

View full text Add to dashboard Cite

show abstract

“…It has been reported that type 1 diabetes (T1D) is associated with only 7% of the increase in cancer risk, while T2D has a greater impact, indicating that the single chronic hyperglycemia environment in diabetes patients is insufficient to aggravate cancer deterioration ( 14 ). Hormonal (insulin resistance), inflammatory, and metabolic characteristics of diabetes are potential links between diabetes and CRC ( 15 ). Moreover, studies found that diabetogenic levels of glucose and insulin can regulate the growth and migration of colon cancer cells ( 16 ), which may be helpful for understanding the relationship between T2D and CRC.…”

Section: Introductionmentioning

confidence: 99%

Oleic Acid and Insulin as Key Characteristics of T2D Promote Colorectal Cancer Deterioration in Xenograft Mice Revealed by Functional Metabolomics

Zhang

Wang

et al. 2021

Front. Oncol.

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Colorectal cancer (CRC) is one of the most commonly diagnosed cancers with high mortality worldwide. Type 2 diabetes mellitus (T2D), known as a risk factor of CRC, can promote the deterioration of CRC, but the underlying mechanism is elusive. In this study, we aimed to reveal the relationship between CRC and T2D from the perspective of small-molecule metabolism. First, a list of common dysregulated metabolites in CRC and T2D was obtained by retrieving existing metabolomics publications. Among these metabolites, oleic acid (OA) was found to be able to promote the proliferation and migration of colon carcinoma cell HCT116. Further experiments proved that insulin could significantly strengthen this promotion and showed a synergistic effect with OA. Mechanism study found that OA and insulin acted synergistically through the extracellular signal-regulated kinase (ERK)1/2/c-Myc/cyclin D1 pathway. In addition, the combination of ERK1/2 inhibitor SCH772984 and cyclin-dependent kinase (CDK)4/6 inhibitor palbociclib showed a remarkable inhibitory effect on tumor growth in vivo. Taken together, the current study found that OA plays an important role in CRC development by using a functional metabolomics approach. More importantly, insulin and OA were confirmed to synergistically promote the deterioration of CRC in vitro and in vivo via ERK1/2/c-Myc/cyclin D1 pathway. Our findings may shed light on CRC treatment among the T2D population.

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Epidemiology and Prevention. I-1. Epidemiology and Risk Factors

Chun

Park

Lim

et al. 2023

Gastrointestinal Cancer

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Diabetes Mellitus: a Clinical Condition Associated with Metabolic Syndrome and Colorectal Cancer Risk

Cited by 3 publications

References 51 publications

A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Oleic Acid and Insulin as Key Characteristics of T2D Promote Colorectal Cancer Deterioration in Xenograft Mice Revealed by Functional Metabolomics

Epidemiology and Prevention. I-1. Epidemiology and Risk Factors

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